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		题名	作者	年代	出处	被引量
	1	Combination of sorafenib and angiotensin-II receptor blocker attenuates preneoplastic lesion development in a non-diabetic rat model of steatohepatitis显示文摘	Hitoshi Yoshiji Ryuichi Noguchi Tadashi Namisaki Kei Moriya Mitsuteru Kitade Yosuke Aihara Akitoshi Douhara Hideto Kawaratani Norihisa Nishimura Hiroshi Fukui	2014	Journal of Gastroenterology2014，，：	1
	2	DNA methylation of angiotensin Ⅱ receptor gene in nonalcoholic steatohepatitis-related liver fibrosis显示文摘AIM To clarify whether Agtr1 a methylation is involved in the development of nonalcoholic steatohepatitis(NASH)-related liver fibrosis in adult rats.METHODS A choline-deficient amino acid(CDAA) diet model was employed for methylation analysis of NASH-related liver fibrosis.Agtr1 a methylation levels were measured in the livers of CDAA- and control choline-sufficient amino acid(CSAA)-fed rats for 8 and 12 wk using quantitative methylation-specific PCR.Hepatic stellate cells(HSCs) were isolated by collagenase digestion of the liver,followed by centrifugation of the crude cell suspension through a density gradient.Agtr1 a methylation and its gene expression were also analyzed during the activation of HSCs.RESULTS The mean levels of Agtr1 a methylation in the livers of CDAA-fed rats(11.5% and 18.6% at 8 and 12 wk,respectively) tended to be higher(P = 0.06 and 0.09,respectively) than those in the livers of CSAA-fed rats(2.1% and 5.3% at 8 and 12 wk,respectively).Agtr1 a was not methylated at all in quiescent HSCs,but was clearly methylated in activated HSCs(13.8%,P < 0.01).Interestingly,although Agtr1 a was hypermethylated,the Agtr1 a m RNA level increased up to 2.2-fold(P < 0.05) in activated HSCs compared with that in quiescent HSCs,suggesting that Agtr1 a methylation did not silence its expression but instead had the potential to upregulate its expression.These findings indicate that Agtr1 a methylation and its upregulation of gene expression are associated with the development of NASH-related liver fibrosis.CONCLUSION This is the first study to show that DNA methylation is potential y involved in the regulation of a renin-angiotensin system-related gene expression during liver fibrosis.	Kiyoshi Asada Yosuke Aihara Hiroaki Takaya Ryuichi Noguchi Tadashi Namisaki Kei Moriya Masakazu Uejima Mitsuteru Kitade Tsuyoshi Mashitani Kosuke Takeda Hideto Kawaratani Yasushi Okura Kosuke Kaji Akitoshi Douhara Yasuhiko Sawada Norihisa Nishimura Kenichiro Seki Akira Mitoro Junichi Yamao Hitoshi Yoshiji	2016	World Journal of Hepatology2016，8，28：	1
	3	Ferroelectric properties of crystalline-oriented lead-zirconate-titanates formed by sol-gel deposition technique显示文摘	Aoki Katsuhiro Fukuda Yukio Numata Ken Nishimura Akitoshi	1995	Japanese Journal of Applied Physics1995，，34：	1
	4	Reduction of endotoxin attenuates liver fibrosis through suppressionof hepatic stellate cell activation and remission of intestinal permeability ina rat non-alcoholic steatohepatitis model显示文摘	Akitoshi Douhara Kei Moriya Hitoshi Yoshiji Ryuichi Noguchi Tadashi Namisaki Mitsuteru Kitade Kosuke Kaji Yosuke Aihara Norihisa Nishimura Kosuke Takeda Yasushi Okura Hideto Kawaratani Hiroshi Fukui	2015	Molecular Medicine Reports2015，，3：	1

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