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| 1 | Method Development of Enantiomer Separations by Affinity Capillary Electrophoresis,Cyclodextrin Electrokinetic Chromatography and Capillary Electrophoresis-Mass Spectrometry显示文摘Capillary electrophoresis (CE) has become a powerful tool for enantiomer separations during the last decade. Since 1993, the author has investigated enantiomer separations by affinity capillary electrophoresis (affinity CE) with some proteins and by cyclodextrin electrokinetic chromatography (CDEKC) with some charged cyclodextrins (CDs). Many successful enantiomer separations are demonstrated from our study in this review article. In the enantiomer separations by affinity CE, the deterioration of detection sensitivity was observed under high concentration of the protein in running solutions. The partial filling technique was practically useful to solve the serious problem. It allowed operation at high protein concentrations, such as 500 μmol/L, without the detection problem. Charged CDs had several advantages for the enantiomer separations over neutral ones. Strong electrostatic interactions between a charged CD and oppositely charged analytes should be effective for the formation of the complex. A large difference in electrophoretic mobility between the free analyte and the inclusion complex should also enhance the enantiomeric resolution. In CE mass spectrometry (CE MS), the partial filling technique was applied to avoid the introduction of nonvolatile chiral selectors into the CE MS interface. By replacing the nonvolatile electrolytes in the running buffer by volatile ones, the separation conditions employed in CE with the UV detection method could be transferred to CE MS. | TANAKA Yoshihide (Department of Analytical Chemistry, Nippon Boehringer Ingelheim Co. Ltd., 3 10 1, Yato, Kawanishi, Hyogo 666 0193, Japan) | 2002 | 色谱2002，20，4： | 8 |
| 2 | Bone Density and Mechanical Properties in Femoral Bone of Swim Loaded Aged Mice显示文摘Effects of swirnming on bone density and mechanical properties of femur were investigated in aged male and female mice. R/1 strain of senescence accelerated mouse (SAM) at eleven months old was used. Two groups of males and two groups of females each consisting of 7 mice were used. One male and one female groups were loaded with a swim regiment of 40 min a day, 5 days a week for 6 consecutive weeks. The remaining groups were used as the controls. All mice were fed with the standard diet and water ad libitum during the experiments.The results of this study indicated that (i) the hady weight was significantly (P<0.05) lower in the swimming groups than in the control groups in boh sexes. (ii) The bone density was significantly higher (P <0.05) in the swimming groups than in the control groups in boh sexes. However, there was no sighficant difference in cortical thickness index. (iii) In the mechanical properties of bone, there were no significant differences in the level of the maximum breaking force, the ultimate stress and the deformation between the swimndng and the contro groups in beth sexes. However, the elasticity of the bone of the female hoce in the swimming group was significantly higher (P<0.05) than that of the control group.These results suggest that regimented swimming for the aged mice might suppress age-associated bone loss, and the effect of exercise in the females is greater that in the males. | AKIO HOSHI HIROMI WATANABE MOMOKO CHIBA AND YUTAKA INABA (Department of Health and Physical Education, Nippon Dental University, 1-8-2 Fu-jimi, Chiyoda-ku, Tokyo, Japan )(Department of Health and Physical Education, Nippon Dental University, Fugimi, T | 1998 | Biomedical and Environmental Sciences1998，11，3： | 4 |
| 3 | Antioxidative properties of ascorbyl palmitate显示文摘 | Nippon Roshu K | 1992 | Jpn Fudo Saiensu1992，31，9： | 1 |
| 4 | Development of high-performance automotive three-way palladium catalyst using nickel aluminate support 显示文摘 | Yamamoto S Matsushita K Nippon Kagaku Kaishi | 2000 | Chemistry and Industrial Chemistry Journal2000，，8： | 1 |
| 5 | Pharmacological and clinical profile of thefree radical scavenger edaravone as a neuroprotectiveagent M显示文摘 | Nippon | 2002 | Yakurigaku Zasshi2002，119，5： | 1 |
| 6 | A case of acute hemorrhagic gangrenous acalculous cholecystits with bile peritonitis during anti-coagulant therapy after coronary-artery bypass grafting显示文摘 | NIPPON KYOBU GEKA GAKKAI ZASSHI | 1993 | Am Surg1993，41，1： | 1 |
| 7 | Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent M 显示文摘 | Tanaka Nippon | 2002 | Yakurigaku Zasshi2002，119，5： | 1 |
| 8 | New tension control method for hot strip mills显示文摘 | KOKAN K K Nippon | 1986 | Trans Iron Steel Inst1986，26，3： | 1 |
| 9 | Anti - tumor effect of interferon for hepatocellular carcinoma - from the clinical consideration显示文摘 | Nippon Shokakibyo Gakkai Zasshi | 2007 | Cancer2007，104，5： | 1 |
| 10 | Properties of keratinolytic proteinases produced by Candida albicans 显示文摘 | Nippon Hifuka Gakkai Zasshi | 1983 | Biochemical1983，93，4： | 1 |
| 11 | Clinical factors associated with benign renal tumors显示文摘 | YAMASHITA R NAKAMURA M NIPPON HINYOKIKA GAKKAI ZASSHI | 2009 | Japanese2009，100，7： | 1 |
| 12 | The mechanisms whereby insulin/IGF-1 signaling regulates aging and longevity 显示文摘 | Nippon R | 2009 | Article In Japanese2009，67，7： | 1 |
| 13 | Hair growth effect of minoxidil 显示文摘 | Nippon | 2002 | Yakurigaku Zasshi2002，119，3： | 1 |
| 14 | Studies on microcirculation injury of skeletal muscle due to tourniquet-induced ischemia显示文摘 | | 1987 | Journnal of the lapanese orthopaedic associalion1987，61，4： | 1 |
| 15 | PROPERTIES OF MODIFIED 9Cr-1Mo STEEL TUBES FOR BOILER USAGE显示文摘 | NIPPON KOKAN KK | | 0，，： | 1 |
| 16 | Transition of chemotherapy for metastatic colorectal cancer and recent advances显示文摘 | Muro K Nippon Rinsho | 2010 | Nippon Rinsho2010，68，6： | 1 |
| 17 | Agespecific effects of systolic and diastolic blood pressures on mortality due to cardiovascular diseases among Japanese men (NIPPON DATAS0) 显示文摘 | Okayama A Kadowaki Y Okamura T Hayakawa T Ueshima H The NIPPON DATA80 Research Group | 2006 | J Hypertens2006，24，： | 1 |
| 18 | Evaluation of routine gas determinations in umbilical cord blood at cesareall sec- tion显示文摘 | SU J NIPPON S FUJINKA G | 1993 | Obstetrics and Gynecology1993，45，2： | 1 |
| 19 | 查看详情显示文摘 | K.Aoki O.Izumi Nippon Kinzoku Gakkaishi | | 0，，： | 1 |
| 20 | Anti-cancer action by PPARgamma ligand显示文摘 | Okumura T Nippon Rinsho | 2010 | Nippon Rinsho2010，68，2： | 1 |
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