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| 1 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 2 | Oscillation analysis of a DFIG-based wind farm interfaced with LCC-HVDC显示文摘With the increasing capacity of wind farm, HVDC technology has become a promising transmission scheme for long distance transportation of large-scale wind power. However oscillation caused by this system will have a great influence on the security and stability of power system operation. In this paper, the oscillation of a doubly-fed induction generator(DFIG)-based wind farm interfaced with line commutated converter(LCC) based HVDC is discussed. Low-frequency oscillation and subsynchronous oscillation(SSO) are studied since these two oscillations are the particularly concerned oscillations in the stability study of power system in recent years. The model of a DFIG-based wind farm interconnected with LCC-HVDC is developed. The impact of drive train model's structure and parameters on the oscillation characteristics is analyzed. Eigenvalue and participation factor analysis are used to identify the three main modes, which include controller mode, electromechanical mode, and shaft mode. The effects of DFIG controller's parameters, wind speed and operating conditions of HVDC on those modes are studied. Electromagnetic transient simulations are performed to verify the results of the eigenvalue analysis. | YANG Lin XIAO Xiang Ning PANG Cheng Zong | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 3 | A new free-hand pedicle screw placement technique with reference to the supraspinal ligament显示文摘We sought to compare the safety and accuracy of a new free-hand pedicle screw placement technique to that of the conventional technique.One hundred fifty-three consecutive adult patients with simple fracture in the thoracic or/and lumbar spine were alternately assigned to either the new free-hand or the conventional group.In the new free-hand technique group,preoperative computerized tomography(CT) images were used to calculate the targeted medial-lateral angle of each pedicle trajectory and the pedicle screw was inserted perpendicular to the corresponding supraspinal ligament.In the conventional technique group,the medial-lateral and cranial-caudal angle of each pedicle trajectory was determined by intraoperatively under fluoroscopic guidance.The accuracy rate of pedicle screw placement,the time of intraoperative fluoroscopy,the operating time and the amount of blood loss during operation were respectively compared.All screws were analyzed by using intraoperative radiographs,intraoperative triggered electromyography(EMG) monitoring data,postoperative CT data and clinical outcomes.The accuracy rate of pedicle screw placement in the new free-hand technique group and the conventional technique group was 96.3% and 94.2%(P < 0.05),respectively.The intraoperative fluoroscopy time of the new technique group was less than that of the conventional technique group(5.37 seconds vs.8.79 seconds,P < 0.05).However,there was no statistical difference in the operating time and the amount of blood loss during operation(P > 0.05).Pedicle screw placement with the free-hand technique which keeps the screw perpendicular to the supraspinal ligament is an accurate,reliable and safe technique to treat simple fracture in the thoracic or lumbar spine. | Juming Li Hong Zhao Hao Xie Lipeng Yu Jifu Wei Min Zong Feng Chen Ziqiang Zhu Ning Zhang Xiaojian Cao | 2014 | The Journal of Biomedical Research2014，28，1： | 7 |
| 4 | Biogeographic characteristics of Zhesi brachiopod fauna and reconstruction of tectonopaleogeography of Jiamusi-Mongolia Block显示文摘The Kungurian-Capitanian ( Permian) Zhesi branchiopod fauna is mainly composed of cold-water typed taxa with high diversity and abundance. This fauna is similar with the coeval brachiopod faunas from Timan-Pechora,Svalbard,and Queen Elizabeth Islands of the Boreal Realm,with no real'warm-water'species. Zhesi brachiopod fauna is a cold-water fauna and should be assigned to the Boreal Realm. Considering the paleogeographic characteristics of this fauna and the basic rationale of paleobiogeographic provinces being controlled by latitude-temperate,and that the above areas were located at 50°N 70°N in the global paleoclimate reconstruction map compiled by Boucot et al. ,the paleo-latitude of the southern margin of Jiamusi-Mongolia Block,where developed the Zhesi brachiopod fauna,is suggested ranging from 40°N to 60°N. Zhesi brachiopod fauna is an endemic fauna,containing more than 75% endemic species and self-grouped as a biogeographic province,termed Inner Mongolia Province. These characteristics indicate that this area was closed or semiclosed at that time. On the Jiamusi-Mongolia Block,the Herlen-Jiamusi Old-land as an obvious 'continental barrier'hindered the northward migration of the Zhesi brachiopod fauna and the immigration of brachiopod species from other areas. The Tarim plate has collided with the Kazakhstan plate and the western part of South Tianshan-Beishan-Xar Moron Ocean has been closed. At the same time,the western margin of Jiamusi-Mongolia Block was joined with the Tarim plate. The Xar Moron Ocean in south of Jiamusi-Mongolia Block was wide enough and the ocean temperature rose gradually southward,so that it is not suitable for the cold-water brachiopods to survive and thrive on the northern margin of the North China plate. Thus,the ocean with large width and high temperature formed another natural barrier for the southward migration of the cold-water brachiopods. | WANG Chengwen LI Ning ZONG Pu | 2012 | Global Geology2012，15，2： | 6 |
| 5 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 6 | Coevolution of brachiopod paleobiogeography and tectonopaleogeography during the late Paleozoic in Central Asia显示文摘Patterns of brachiopod paleobiogeographic regionalization in Central Asia reveal a coevolution between brachiopod paleobiogeography and tectonopaleogeography during the Early Devonian,Early Carboniferous,Late Carboniferous,Early Permian,and Middle Permian.The coevolutionary relationship reasonably accounts for the formation mechanisms of brachiopod paleobiogeography in this region,and also provides a basis for studies on the location and configuration of oceans and plates(blocks)during the late Paleozoic in Central Asia. | WANG ChengWen ZHAO GuoWei LI Ning ZONG Pu | 2013 | Science China Earth Sciences2013，56，12： | 5 |
| 7 | Stratigraphic framework of late Paleozoic in northeastern China显示文摘Late Paleozoic strata in northeastern China are distributed in a zonal pattern around the old-land on the Jiamusi-Mongolia Block.They are composed of active deposits in the regular distributed tectonic lithofacies zones.This indicates that the late Paleozoic strata belong to continental margin deposits.According to the strong conformability of the sedimentary strata in the same continental margin and distinct differences among the three continental margins,three stratigraphical regions of the Jiamusi-Mongolia Stratigraphical Province are recognized along the northern,southern and eastern margins of the Jiamusi-Mongolia Block,named respectively as Xing'an Stratigraphical Region,Inner Mongolia grass--Songhua River Stratigraphical Region and Baoqing--Hunchun Stratigraphical Region.Due to the characteristics of continental margin deposits and active sediments,the strata can be correlated on the level of formation by the methods of analysing the rock association in the same stratigraphic region.Therefore,some revisions of the lithological formations of the late Paleozoic strata in northeastern China have been made,and a new chart of lithostratigraphic correlation has been proposed.Furthermore,the present stratigraphic framework is setting on the International Stratigraphic Chart on the level of stage,after comprehensive researches to lithostratigraphy,biostratigraphy and chronostratigraphy,especially the conodont biostratigraphy and isotopic ages of volcanic rocks obtained in recent years. | WANG Chengwen LI Ning SUN Yuewu ZONG Pu ZHAO Guowei LIU Hui MA Xiaoqin | 2013 | Global Geology2013，16，1： | 4 |
| 8 | Agricultural Land Suitability of Production Space in the Taihang Mountains, China显示文摘The contradiction between the shortage of land for agriculture due to rapid expansion of industrialization and urbanization and increasing population pressure is projected to impose great threats to future food security.Agricultural land suitability evaluation is an effective approach to improve the utilization of land resources for crop production and thus enhance the capacity of food provision.In this study, we evaluated the land suitability for agriculture of the production space in the Taihang Mountains by three steps: establishing indicator system, determining weights for indicators, and constructing a fuzzy matter-element model to assess the grades of suitability.Results showed that the land suitability had a significant linear correlation with potential crop yields, indicating our evaluation was effective to predict crop production.The spatial pattern of land suitability for crop production demonstrated that land with higher suitability was generally located in piedmont plains and basins, while land with lower suitability was mostly situated in mountainous areas.The area of highly, moderately, marginally suitable and unsuitable land for agriculture was 32.13%, 28.58%, 37.49% and 1.80% of the production space, respectively.However, the correlation degree analysis indicated that the requirements of these four suitability grades were currently not satisfied but could be potentially fulfilled.In terms of indicator weights, soil properties were much more important than topography and location conditions to influence the grades of suitability.Among all indicators, slope, soil organic matter, soil texture and soil depth were the most influential factors, so slope farming prevention and organic fertilization were most likely to improve land suitability for agriculture.Compared the outputs of our land suitability evaluation model with the distribution of the existing croplands, we found that about 66.52% of marginally suitable and 54.55% of unsuitable land for agriculture were currently used for croplands.Therefore, de-farming policy should be implemented in areas of these two suitability grades.In contrast, cropland expansion was encouraged in the land that was highly or moderately suitable for agriculture.Our evaluation of agricultural land suitability is beneficial for future land use planning and decision-making in the Taihang Mountains. | GENG Shoubao SHI Peili ZONG Ning ZHU Wanrui | 2019 | Chinese Geographical Science2019，29，6： | 4 |
| 9 | Prognostic value of plasma C-reactive protein in the evaluation of paraquat poisoning patients显示文摘Objective: To investigate the prognostic value of plasma C-reactive protein(CRP) level in patients with paraquat poisoning.Methods: This study included 162 patients with paraquat poisoning. The data of plasma paraquat, CRP level and arterial blood gas were analyzed. Cox regression analysis was applied to evaluate the risk factors of prognosis. Receiver operating characteristics curve analysis and area under curve were used to calculate the predictive power of significant variable. Differences in patient survival were determined using the Kaplan–Meier method and a log-rank test.Results: Plasma CRP level was significantly increased in non-survival patients compared with survival patients(P < 0.05), and positively correlated with plasma paraquat level(P < 0.05). Cox regression analysis revealed that plasma CRP level was an independent prognostic marker of mortality within 30 days. The receiver operating characteristics curve analysis indicated that area under curve of plasma CRP level was0.867(95% CI: 0.81–0.93), and the cut-off value was 18 mg/L, and patients with CRP level over this value had a poor survival time compared with those with less than this value.Conclusions: These results suggest that plasma CRP level is distinct increased in patients with paraquat poisoning, and the plasma CRP level may be useful for the prediction of prognosis in paraquat poisoning. | Zong Ning Yu-Long Bai Hua Lu Kang-Lin Mo | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 3 |
| 10 | Coevolution of Brachiopod Paleobiogeography and Tectonopaleogeography during the Early–Middle Permian显示文摘A comprehensive compilation and systematic analysis of known early and middle Permian brachiopod faunas shows that the early Permian brachiopod faunas comprise three realms, six regions, and eleven provinces, while those of the middle Permian comprise three realms, four regions, and eight provinces. A comparison and analysis of brachiopod faunal patterns reveal a coevolution between global brachiopod paleobiogeography and tectonopaleogeography during the early–middle Permian. Although temperature/latitude is the main factor controlling the formation of three realms, tectonopaleogeographic factors determine the temperature/latitude in which the continents were located. The ‘continental barrier' of Pangea, as a ‘central axis' continent, divided the three realms into six regions, which indicates that the formation of biogeographic regions was controlled mainly by the tectonopaleogeographic factors. The evolution of tectonopaleogeography was sometimes a long-term process, so that the biogeographic regions(or provinces) controlled by tectonopaleogeography displayed relative stability. Shifts in the nature of biogeographic provinces(e.g., from cool water to warm water, and vice versa), extensions or narrowing of geographical ranges, and recombinations of some provinces were all related to regional tectonic evolution. The study of the coevolution between brachiopod paleobiogeography and tectonopaleogeography not only accounts for the formation mechanisms of brachiopod paleobiogeographic patterns during the early–middle Permian, but also provides evidences for the locations and configurations of oceans and plates(blocks) during this period. | WANG Chengwen MAO Yongqin LI Ning ZONG Pu | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 2 |
| 11 | Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma显示文摘BACKGROUND The clinicopathological features and prognosis of gastric signet ring cell carcinoma(GSRC)remain controversial,particularly with regard to sensitivity to postoperative adjuvant therapy.AIM To compare the pathological features of GSRC with those of gastric adenocarcinoma of different degrees of differentiation and the differences in survival prognosis between the different disease processes.METHODS By screening gastric cancer patients from 2010 to 2015 in the database of Surveillance,Epidemiology and End Results,and collecting the clinicopathological and prognostic data of gastric cancer patients who underwent surgery from January 2014 to December 2016 in the Second Affiliated Hospital of Nanchang University,we analyzed the general pathological characteristics of GSRC by the chi-square test.Univariate and multivariate analyses were conducted to compare the factors affecting the survival and prognosis of early and advanced gastric adenocarcinoma.The Kaplan-Meier curves were plotted to reveal the survival difference between early and advanced GSRC and different differentiated types of gastric adenocarcinoma.The prognosis model of advanced GSRC was established with R software,and the area under curve(AUC)and C-index were used to assess the accuracy of the model.RESULTS Analysis of pathological features revealed that signet ring-cell carcinoma(SRC)was more frequently seen in younger(<60 years),female,and White patients compared to non-SRC patients.SRC was less commonly associated with early gastric cancer(EGC)(23.60%vs 39.10%),lower N0(38.61%vs 61.03%),and larger tumour sizes>5 cm(31.15%vs 27.10%)compared to the differentiated type,while the opposite was true compared to the undifferentiated type.Survival prognostic analysis found no significant difference in the prognosis of SRC patients among EGC patients.In contrast,among advanced gastric cancer(AGC)patients,the prognosis of SRC patients was correlated with age,race,tumour size,AJCC stage,T-stage,and postoperative adjuvant therapy.The predictive model showed that the 3-year AUC was 0.787,5-year AUC was 0.806,and C-index was 0.766.Compared to non-SRC patients,patients with SRC had a better prognosis in EGC[hazard ratio(HR):0.626,95%confidence interval(CI):0.427-0.919,P<0.05]and a worse prognosis in AGC(HR:1.139,95%CI:1.030-1.258,P<0.05).When non-SRC was divided into differentiated and undifferentiated types for comparison,it was found that in EGC,SRC had a better prognosis than differentiated and undifferentiated types,while there was no significant difference between differentiated and undifferentiated types.In AGC,there was no significant difference in prognosis between SRC and undifferentiated types,both of which were worse than differentiated types.A prognostic analysis of postoperative adjuvant therapy for SRC in patients with AGC revealed that adjuvant postoperative radiotherapy or chemotherapy significantly improved patient survival(34.6%and 36.2%vs 18.6%,P<0.05).CONCLUSION The prognosis of SRC is better than that of undifferentiated type,especially in EGC,and its prognosis is even better than that of differentiated type.SRC patients can benefit from early detection,surgical resection,and aggressive adjuvant therapy. | Hua-Kai Tian Zuo Zhang Zhi-Kun Ning Jiang Liu Zi-Tao Liu Hao-Yu Huang Zhen Zong Hui Li | 2022 | World Journal of Clinical Cases2022，10，29： | 2 |
| 12 | Lithium bis(oxalate)borate crosslinked polymer electrolytes for high-performance lithium batteries显示文摘Solid electrolytes play a vital role in solid-state Li secondary batteries,which are promising high-energy storage devices for new-generation electric vehicles.Nevertheless,obtaining a suitable solid electrolyte by a simple and residue-free preparation process,resulting in a stable interface between electrolyte and electrode,is still a great challenge for practical applications.Herein,we report a self-crosslinked polymer electrolyte(SCPE)for high-performance lithium batteries,prepared by a one-step method based on 3-methoxysilyl-terminated polypropylene glycol(SPPG,a liquid oligomer).It is worth noting that lithium bis(oxalate)borate(Li BOB)can react with SPPG to form a crosslinked structure via a curing reaction.This self-formed polymer electrolyte exhibits excellent properties,including high roomtemperature ionic conductivity(2.6×10^(-4) S cm^(-1)),wide electrochemical window(4.7 V),and high Li ion transference number(0.65).The excellent cycling stability(500 cycles,83%)further highlights the improved interfacial stability after the in situ formation of SCPE on the electrode surface.Moreover,this self-formation strategy enhances the safety of the battery under mechanical deformation.Therefore,the present self-crosslinked polymer electrolyte shows great potential for applications in high-performance lithium batteries. | Xiao Wang Jujie Sun Changhao Feng Xiujuan Wang Minghan Xu Jingjiang Sun Ning Zhang Jun Ma Qingfu Wang Chengzhong Zong Guanglei Cui | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 13 | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances显示文摘Background Working memory(WM)deficit is considered a core feature and cognitive biomarker in patients with schizophrenia.Several studies have reported prominent object WM deficits in patients with schizophrenia,suggesting that visual WM in these patients extends to non-spatial domains.However,whether non-spatial WM is similarly affected remains unclear.Aim This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.Methods The study included 36 patients with first-episode schizophrenia and 35 healthy controls.Visual object WM capacity,including face and house WM capacity,was assessed by means of delayed matching-to sample visual WM tasks,in which participants must distribute memory so that they can discriminate a target sample.We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale.Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results Both face and house WM capacity was significantly impaired in patients with schizophrenia.For both tasks,the performance of all the subjects was worse under the high-load condition than under the low-load condition.We found that WM capacity was highly positively correlated with the performance on RBANS total scores(r=−0.528,p=0.005),RBANS delayed memory scores(r=−0.470,p=0.013),RBANS attention scores(r=−0.584,p=0.001),RBANS language scores(r=−0.448,p=0.019),Trail-Making Test:Part A raw scores(r=0.465,p=0.015)and simple IQ total scores(r=−0.538,p=0.005),and correlated with scores of the vocabulary test(r=−0.490,p=0.011)and scores of the Block Diagram Test(r=−0.426,p=0.027)in schizophrenia.No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.Conclusions Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition,suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. | Yi Liu Taiyong Bi Bei Zhang Qijie Kuang Haijing Li Kunlun Zong Jingping Zhao Yuping Ning Shenglin She Yingjun Zheng | 2021 | General Psychiatry2021，34，1： | 2 |
| 14 | Experimental investigation on the spread of aqueous foam over ethanol surface显示文摘The presence of ethanol has an adverse effect on foam spreading,and ethanol fire is difficult to extinguish with aqueous fire-fighting foams.Thus,it is necessary to explore the foam formulation suitable for ethanol fuels and study the spreading behavior of foam over ethanol surface.In the current work,stable foams based on hydrocarbon surfactant(SDS),fluorocarbon surfactant(FC1157),and polymers(XG)were prepared by using the compressed-air foam system.The spreading behaviors of foam on polar ethanol and non-polar heptane surface were observed and compared.Furthermore,the effects of stabilizer concentrations,foam flow rates and expansion ratios on foam spreading performance were investigated,respectively.The results indicate that aqueous SDS foam can spread on the heptane layer continuously,but it is difficult to cover the ethanol surface.The addition of XG and FC1157 can synergistically improve the spreading performance of aqueous foam over ethanol.Depending on stabilizer concentrations,there are remarkable differences in foam spreading behaviors.Besides,different foam application parameters including expansion ratios and foam flow rates significantly affect the foam spreading rate,despite the same foam formulation.The research methods and results guide the optimal design of foam formulations as well as the practical application of aqueous foam for ethanol fire extinguishment. | Xiaoyang Yu Fan Li Xuyang Miao Ning Jiang Ruowen Zong Shouxiang Lu Changhai Li State | 2020 | Chinese Journal of Chemical Engineering2020，28，11： | 2 |
| 15 | Inhibition of Erythroid Differentiation of Human Leukemia K562 Cells by N-acetylcysteine and Ascorbic Acid through Downregulation of ROS显示文摘这研究在这个过程在导致 hemin 的 K562 房间 erythroid 区别和反应的氧种类(ROS ) 的角色上调查了 N-acetylcysteine (NAC ) 和维生素酸(AA ) 的效果。Hemin 以一种集中依赖者方式增加了 ROS 层次,而 NAC 和 AA 有相反的效果。NAC 和 AA 在 hemin 处理,禁止的导致 hemin 的血红素合成,和减少的 mRNA 表示以后消除了短暂增加的 ROS 层次 -globin,-globin, 和 GATA-1 基因的层次显著地。当时,有为 2 h 的 5,000 mol/L AA 的预告的处理比那导致了血红素合成的更加更低的抑制比率为 24 h 的 pretreated,而 ROS 层次是最低当为 2 h 与 5,000 mol/L AA 对待时。这些结果证明 NAC 和 AA 可能由 downregulating ROS 层次禁止导致 hemin 的 K562 房间 erythroid 区别。 | YU Chun Hong JIANG Liang WANG Ying CUI Ning Xuan ZHAO Xiao YI Zong Chun | 2018 | Biomedical and Environmental Sciences2018，31，3： | 2 |
| 16 | Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China显示文摘Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses,including many bat-origin viral diseases.However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined,and the link between specific interactions and spillover risk is poorly understood.To investigate this phenomenon,we conducted biological-behavioral surveillance among rural residents in Yunnan,Guangxi,and Guangdong districts of Southern China,where we have identified a number of SARS-related coronaviruses in bats.Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays(ELISA).Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk.A total of 1,596 residents were enrolled in the study from 2015 to 2017.Nine participants(0.6%)tested positive for bat coronaviruses.265(17%)participants reported severe acute respiratory infections(SARI)and/or influenza-like illness(ILI)symptoms in the past year,which were associated with poultry,carnivore,rodent/shrew,or bat contact,with variability by family income and district of residence.This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China.The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event.Nonetheless,this study highlights associations between human-animal interaction and zoonotic spillover risk.These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence. | Li Hongying Mendelsohn Emma Zong Chen Zhang Wei Hagan Emily Wang Ning Li Shiyue Yan Hong Huang Huimin Zhu Guangjian Ross Noam Chmura Aleksei Terry Philip Fielder Mark Miller Maureen Shi Zhengli Daszak Peter | 2019 | Biosafety and Health2019，1，2： | 2 |
| 17 | First enzymatic galactosylation of acyclic nucleoside drugs by β-galactosidase: Synthesis of water-soluble β-D-galactosidic prodrugs显示文摘 | Li-Qiang Yan Ning Li Min-Hua Zong | 2014 | Biotechnology and Bioprocess Engineering2014，，4： | 1 |
| 18 | First and facile enzymatic synthesis of β-fucosyl-containing disaccharide nucleosides through β-galactosidase-catalyzed regioselective glycosylation显示文摘 | Li-Qiang Yan Ning Li Min-Hua Zong | 2012 | Journal of Biotechnology2012，，2： | 1 |
| 19 | Cross-linked enzyme aggregates of β-glucosidase from Prunus domestica seeds显示文摘 | Lei Chen Ying-Dan Hu Ning Li Min-Hua Zong | 2012 | Biotechnology Letters2012，，9： | 1 |
| 20 | (R)- Oxynitrilase-catalyzed synthesis of (R)-2-trimethylsilyl- 2-hydroxylethylcyanide显示文摘 | Ning Li Min-Hua Zong Hua-Song Peng | 2003 | Journal of Molecular Catalysis B: Enzymatic2003，22，12： | 1 |
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