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| 1 | Intestinal lymphangiectasia in adults显示文摘Intestinal lymphangiectasia in the adult may be characterized as a disorder with dilated intestinal lacteals causing loss of lymph into the lumen of the small intestine and resultant hypoproteinemia, hypogamma-globulinemia, hypoalbuminemia and reduced number of circulating lymphocytes or lymphopenia. Most often, intestinal lymphangiectasia has been recorded in children, often in neonates, usually with other congenital abnormalities but initial def inition in adults including the elderly has become increasingly more common. Shared clinical features with the pediatric population such as bilateral lower limb edema, sometimes with lymphedema, pleural effusion and chylous ascites may occur but these reflect the severe end of the clinical spectrum. In some, diarrhea occurs with steatorrhea along with increased fecal loss of protein, reflected in increased fe- cal alpha-1-antitrypsin levels, while others may present with iron def iciency anemia, sometimes associated with occult small intestinal bleeding. Most lymphangiectasia in adults detected in recent years, however, appears to have few or no clinical features of malabsorption. Diagnosis remains dependent on endoscopic changes confirmed by small bowel biopsy showing histological evidence of intestinal lymphangiectasia. In some, video capsule endoscopy and enteroscopy have revealed moreextensive changes along the length of the small intes- tine. A critical diagnostic element in adults with lym- phangiectasia is the exclusion of entities (e.g. malignancies including lymphoma) that might lead to obstruction of the lymphatic system and 'secondary' changes in the small bowel biopsy. In addition, occult infectious (e.g. Whipple's disease from Tropheryma whipplei) or in? am- matory disorders (e.g. Crohn's disease) may also present with profound changes in intestinal permeability and protein-losing enteropathy that also require exclusion. Conversely, rare B-cell type lymphomas have also been described even decades following initial diagnosis of intestinal lymphangiectasia. Treatment has been historically def ined to include a low fat diet with medium-chain triglyceride supplementation that leads to portal venous rather than lacteal uptake. A number of other pharma- cological measures have been reported or proposed but these are largely anecdotal. Finally, rare reports of localized surgical resection of involved areas of small intestine have been described but follow-up in these cases is often limited. 2011 Baishideng. All rights reserved. | Hugh James Freeman Michael Nimmo | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 13 |
| 2 | Novel susceptibility genes in inflammatory bowel disease显示文摘The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. | Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell Jack Satsangi | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 3 | Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics显示文摘 | Nicholas T. Ventham Nicholas A. Kennedy Elaine R. Nimmo Jack Satsangi | 2013 | Gastroenterology2013，，2： | 3 |
| 4 | The reliability of Michaelis constants and maximum velocities estimated by using the integrated Michaelis-Menten equation显示文摘 | Atkins G L Nimmo I A | 1973 | Biochem J1973，135，4： | 2 |
| 5 | Statin therapy is associated with fewer deaths in patients with bacteraemia显示文摘 | Peter Kruger Kenneth Fitzsimmons David Cook Mark Jones Graeme Nimmo | 2006 | Intensive Care Medicine2006，，1： | 2 |
| 6 | Rehabilitation of execu- tive dysfunction following brain injury: Content-free cueing improves everyday prospective memory performance显示文摘 | Fish J Evans JJ Nimmo M | 2007 | Neu- ropsyehologia2007，45，： | 1 |
| 7 | An elegant miRror: microRNAs in stem ceils, developmental timing and cancer显示文摘 | Nimmo RA Slack FJ | 2009 | Chromo- soma2009，118，4： | 1 |
| 8 | Contribution of the NOD1/CARD4 inser- tion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe显示文摘 | VAN LIMBERGEN J RUSSELL R K NIMMO E R | 2007 | Inflamm Bowel Dis2007，13，： | 1 |
| 9 | Telomere associated chromosome breakage in fission yeast results in variegated expression of adjacent genes 显示文摘 | Nimmo ER Cranston G Allshire RC | 1994 | EMBO J1994，13，16： | 1 |
| 10 | Novel therapies in development for the treatment of traumatic brain injury显示文摘 | Nimmo AJ | 2002 | Expert Opin Investig Drugs2002，11，6： | 1 |
| 11 | Calcium-based sorbents for simultaneous NOx/SOx reduction in a down-fired furnace显示文摘 | Patsias A A Nimmo W Gibbs B M | 2005 | Fuel2005，84，1415： | 1 |
| 12 | Proteins in hlynya I wheat chemistry and technology显示文摘 | Pence J W Nimmo C C | 1951 | AACC St Paul Minnesota1951，5，： | 1 |
| 13 | The measurement of gastric emptying during labour显示文摘 | Walter S Nimmo BSc MB | 1978 | J Int Med Res1978，6，1： | 1 |
| 14 | Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats显示文摘 | Connor CA Nimmo AJ | 2003 | Neurosci Lett2003，336，1： | 1 |
| 15 | Calcium magnesium acetate and urea advanced reburning for NO control with simultaneous SO2 reduetion显示文摘 | Nimmo W Patsias A A Hampartsoumian E | 2004 | Fuel2004，83，9： | 1 |
| 16 | 显示文摘 | Kong CL Nimmo T Elatrozy V | 2001 | Antherosclerosis2001，156，： | 1 |
| 17 | Calcium magnesium acetate and urea advanced reburning for NO control with simultaneous SO2 reduction显示文摘 | NIMMO W PATSIAS A A HAMPARTSOUMIAN E | 2004 | Fuel2004，83，9： | 1 |
| 18 | Calcium-based sorbents for simultaneous NOx/SOx reduction in a down-fired furnace显示文摘 | Patsias A A Nimmo W Gibbs B M | | 0，，14： | 1 |
| 19 | Estima- ting groundwater recharge in Hebei Plain, China under varying land use practices using tritium and bromide trac-ers显示文摘 | Wang Bingguo Jin Menggui Nimmo J R | 2008 | Journal of Hydrology2008，356，12： | 1 |
| 20 | The intermediate filament protein, vimentin, is a regulator of NOD2 activity 显示文摘 | Stevens C Henderson P Nimmo ER | 2013 | Gut2013，62，5： | 1 |
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