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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Blood pressure management in acute stroke显示文摘Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor outcomes.Whether to modulate BP in acute stroke has long been debated.With the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal ischaemia.Published evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic stroke.Here we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit. | Jason P Appleton Nikola Sprigg Philip M Bath | 2016 | Stroke & Vascular Neurology2016，1，2： | 7 |
| 3 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 4 | Primary liposarcoma of esophagus:A case report显示文摘当食道的脂肪的肉瘤是一个极其稀罕的肿瘤时,脂肉瘤是在成年生命的最普通的软织物肉瘤。在世界文学,仅仅食道的脂肪的肉瘤的 14 个案例被描述了。我们报导着急地与一枚燃烧制动火箭为剧烈腹上部的疼痛进入我们的医院的一个 72 年的老男病人胸骨的感觉,坚持的恶心,呕吐并且咽下困难。钡燕子,上面胃肠(官方补给) 内视镜检查法,食道的测压法和 CT 扫描,没能精确地诊断损害。在一个食道的息肉样瘤的外科的切除术以后,组织学的考试揭示了一个区分得好的等级我脂肪的肉瘤。诊断、治疗学的工具被讨论,文学的结果被考察。 | Theodore D Liakakos Theodore G Troupis Charalambos Tzathas Konstantina Spirou Irene Nikolaou Spiridon Ladas Gabriel M Karatzas | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 5 | Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel显示文摘Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment resistance.The primary aim was to assess the proportion of patients who are insensitive to clopidogrel.The secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular events.Methods Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were enrolled.Platelet function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or clopidogrel.Participants’general practitioners provided details on recurrent vascular events at least 90 days later.Data are mean(SD)and median[IQR].Resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 units.Non-parametric descriptors and tests were used.Results 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and aspirin.Assessment of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin resistance.Thirteen(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=0.08.Conclusions Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed resistance.No significant associations were noted between clopidogrel resistance and recurrent ischaemic events. | Jason Philip Appleton Carla Richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 6 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 7 | Modelling time-kill studies to discern the pharmacodynamics of meropenem 显示文摘 | Tam VH Schilling AN Nikolaou M | 2005 | J Antimicrobial Chemotherapy2005，55，5： | 1 |
| 8 | Molecular pathways:the complex roles of inflammation pathways in the development and treatment of liver cancer显示文摘 | Nikolaou K Sarris M Talianidis I | 2013 | Clin Can Res2013，19，11： | 1 |
| 9 | Ex vivo coronary atheroscle-rotic plaque characterization with multi detector row CT显示文摘 | Becker CR Nikolaou K Muders M | 2009 | Eur Radi-ol2009，13，9： | 1 |
| 10 | MPC: current practice and challenges 显示文摘 | Darby M L Nikolaou M | 2012 | Control Engineering Practice2012，20，4： | 1 |
| 11 | Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries显示文摘 | Nikolaou K Becker CR Muders M | 2004 | Atherosclerosis2004，174，2： | 1 |
| 12 | Epidemiology of laryngeal cancer in Osijek - Baranja County( Eastern Croatia) 显示文摘 | Marinela R Nikola K Ivan M | 2012 | Coil Antro- pol2012，36，2： | 1 |
| 13 | Real-time reservoir management: a multi-scale adaptive optimization and control approach 显示文摘 | SAPUTELLI L NIKOLAOU M ECONOMIDES M J | 2005 | Computational Geosciences2005，10，1： | 1 |
| 14 | Adjuvant and neo- adjuvant chemotherapy in muscle invasive bladder cancer: lit- erature review显示文摘 | Pectasides D Pectasides M Nikolaou M | 2005 | Eur Urol2005，48，1： | 1 |
| 15 | Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT显示文摘 | Becker CR Nikolaou K Muders M | 2003 | Eur Radiol2003，13，9： | 1 |
| 16 | Determination and biological relevance of serum cross-linked type Ⅰ collagen N-telopeptide and bone-specific alkaline phosphatase in breast metastatic cancer显示文摘 | KANAKIS I NIKOLAOU M PECTASIDES D | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，34，4： | 1 |
| 17 | Multi-detector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex-vivo coronary arteries显示文摘 | Nikolaou K Becker CR Muders M | 2004 | Atherosclerosis2004，174，： | 1 |
| 18 | Brain natriuretic peptide increases in septic patients without severe sepsis or shock显示文摘 | Nikolaou NI Goritsas C Dede M | 2007 | Eur J Intern Med2007，18，7： | 1 |
| 19 | Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results显示文摘 | Nikolaou K Sanz J Poon M | 2005 | Eur Radiol2005，15，5： | 1 |
| 20 | Class II myosins in nematodes-genetic relationships, fundamental and applied implications 显示文摘 | Nikolaou S Hu M Chihon NB | 2006 | Biotechnol Adv2006，24，3： | 1 |
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