|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 2 | Market discipline, information disclosure and moral hazard in Banking显示文摘 | Erlend Nier Ursel Baumann | 2006 | Journal of Financial Intermediation2006，15，： | 1 |
| 3 | Banana endophytes:potetial for pest biocontrol显示文摘 | Gold C Coyne D | 2002 | Biocontrol News and Information2002，23，4： | 1 |
| 4 | Network models and financial stability 显示文摘 | Nier Erlend Yang Jing Yorulmazer Tanju Alentom Amadeo | 2006 | Journal of Economic Dynamics and Control2006，，6： | 1 |
| 5 | Market discipline,disclosure and moral hazard in banking显示文摘 | Nier E Baumann U | | 0，，03： | 1 |
| 6 | The effects of selected probiotic strains on he development of eczema ( the Panda study) 显示文摘 | Niers L Martin R Rijkers G Sengers F Timmerman H van Uden N | 2009 | Allergy2009，64，9： | 1 |
| 7 | Mechanisms of heparin induced anticancer activity in experimental cancer models显示文摘 | Niers TM Klerk CP DiNisio M | 2007 | Crit Rev Oncol Hematol2007，61，： | 1 |
| 8 | The NMN/NaMN adenylyltrans- ferase ( NMNAT ) protein family 显示文摘 | Lau C Niere M Ziegler M | 2009 | Front Biosci2009，，14： | 1 |
| 9 | The NMN/NaMN adenylyltransferase (NMNAT) protein family显示文摘 | Lau C M Niere M Ziegler | 2009 | Front Biosci (Landmark Ed)2009，14，： | 1 |
| 10 | Network models and financial stability显示文摘 | Nier E Yang J Yorulmazer Y Alentorn A | | Journal of Economic Dynamics and Control0，31，： | 1 |
| 11 | Variations in the relative abundance of the carbon isotopes显示文摘 | Nier A O gulbransen EA | 1939 | Journal of the American Chemical Society1939，61，： | 1 |
| 12 | Network models and financial stability显示文摘 | Nier E Yang Jing Yorulmazer T | 2007 | Journal of Economic Dynamics and Control2007，31，6： | 1 |
| 13 | Vegetation of the Santa Catalina Mountains,Arzona, (Ⅱ) A gradient analysis of the south slope 显示文摘 | WHITTAKER R H NIERING W A | 1965 | Ecology1965，46，： | 1 |
| 14 | Selection of probiotic bacteria for prevention of allergic diseaes: immunomodulation of neonatal dendritic cells 显示文摘 | Niers LE Hoekstra MO Timmerman HM | 2007 | Clin Exp Immunol2007，149，2： | 1 |
| 15 | Interpreting sea level rise and rates of vertical marsh accretion in a southern New England tidal salt marsh显示文摘 | Orson R A Warren R S Niering W A | 1998 | Estuarine Coastal and Shelf Science1998，47，： | 1 |
| 16 | Network models and financial stability显示文摘 | Nier E Yang J Yorulmazer T | 2007 | Journal of Economic Dynamics and Control2007，31，6： | 1 |
| 17 | Network models and financial stability显示文摘 | Nier E Yang J Yorulmazer T | 2007 | Journal of Economic Dynamics and Control2007，31，6： | 1 |
| 18 | Chemi- cal mechanical polishing of gallium nitride显示文摘 | Taver Nier PR Mar Galith T Coldren L A | 2002 | Electro- chemical and Solid-StateLetters2002，5，8： | 1 |
| 19 | Immobilized metal affinity membrane adsorbers as stationary phases for metal interaction protein separation显示文摘 | Westra DF Reif OW Nier V | 2011 | JourualofChromatographyB2011，760，： | 1 |
| 20 | A Redetermination of the Relative Ab-undances of the Isotopes of Carbon, Nitrogen, Oxygen, Argon and Potassium显示文摘 | | 1950 | Phys Rev1950，77，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员