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887篇 您的检索式：作者名="Nicholson E"

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	题名	作者	年代	出处	被引量
1	基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用.	LINDON J C HOLMES E NICHOLSON J K	2006	波谱学杂志2006，23，1：	10
2	The SOCS proteins:A new family of negative regulators of signal transduction 显示文摘	Nicholson S E Hilton D J	1998	J Leukoc Biol1998，63，6：	3
3	‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘	Nicholson JK Lindon JC Holmes E	1999	Xenobiotica1999，29，11：	2
4	Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids显示文摘	Lindon JC Nicholson JK Holmes E Everett JR	2000	Concepts Magn Reson2000，12，5：	2
5	Metabonomics: a platform for studying drug toxicity and gene function显示文摘	Nicholson JK Connelly J Lindon JC Holmes E	2002	Nat Rev Drug Discov2002，1，2：	2
6	Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabialistic neural networks显示文摘	Holmes E Nicholson JK Tranter G	2001	Chem Res Toxicol2001，14，2：	2
7	An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse显示文摘	Gavaghan CL Holmes E Lenz E Wilson ID Nicholson JK	2000	FEBS Lett2000，484，3：	2
8	' Metabonomics' : understanding the met abolic responses of living systems to pathophysio logical stimuli via multivariate statistical analysis of biological NMR spectrosc-opic data 显示文摘	Nicholson JK Lindon JC Holmes E	1999	Xenobiotica1999，29，1：	1
9	Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project显示文摘	Lindon JC Nicholson JK Holmes E	2003	Toxicol Appl Pharmacol2003，187，3：	1
10	The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine 显示文摘	Holmes E Nicholson JK Nichols AW	1998	Chemom Intell Lab Syst1998，44，3：	1
11	'Metabonomies' : understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data显示文摘	Nicholson JK Lindon JC Holmes E	1999	Xenobi- otica1999，29，11：	1
12	‘Metabonomics’:Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘	Nicholson JK Lindon JC Holmes E	1999	Xenobiotica1999，29，11：	1
13	Toxicological applications of magnetic resonance显示文摘	LINDON J C HOLMES E NICHOLSON J K		0，，：	1
14	An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy 显示文摘	Coen M Lenz E M Nicholson J K	2003	Chem Res Toxicol2003，16，3：	1
15	EGFR and cancer prognosis显示文摘	Nicholson R I Gee J M Harper M E	2001	Eur J Cancer2001，37，4：	1
16	Metabonomics techniques and applications to pharmaceutical research&development 显示文摘	LINDON J C HOLMES E NICHOLSON J K	2006	Pharm Res2006，23，6：	1
17	Observations of Col- letotrichum graminicola on sweet corn in Indiana 显示文摘	Warren H Nicholson R Ullstrup A Sharvelle E	1973	Plant Disease Re- port1973，，57：	1
18	Small Firms and Offshore Software Outsourcing:High Transaction Costs and Their Mitigation显示文摘	Camel E Nicholson B		0，，09：	1
19	' Metabonomics ' : understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘	Nicholson JK Lindon JC Holmes E	1999	Xenobiotica1999，29，11：	1
20	The challenges of modeling mammalian bioeomplexity显示文摘	Nicholson J K Holmes E Lindon J C	2004	Nature Biotechnology2004，22，：	1

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