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| 1 | Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy显示文摘Background:Asians are diagnosed with breast cancer at a younger age than Caucasians are.We studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving therapy.Methods:Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were reviewed.The Kaplan-Meier method was used to estimate locoregional recurrence,breast cancer-free survival,and breast cancer-specific survival rates.These rates were then compared using log-rank tests.Outcomes and age were modeled by Cox proportional hazards.Fractional polynomials were then used to test for non-linear relationships between age and outcomes.Results:Patients≤40 years old were more likely to have locoregional recurrence than were older patients(Hazard ratio[HR]=2.32,P<0.001).Locoregional recurrence rates decreased year-on-year by 4%for patients with luminal-type breast cancers,compared with 8%for those with triple-negative cancers.Similarly,breast cancer-free survival rates increased year-on-year by 4%versus 8%for luminal-type and triple-negative cancers,respectively.Breast cancer-spe-cific survival rates increased with age by 5%year-on-year.Both breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear(“L-shaped”)relationship-where decreasing age at presentation was associated with escalating risks of relapse and death.The influence of age on overall survival was confounded by competing non-cancer deaths in older women,resulting in a“U-shaped”relationship.Conclusions:Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold. | Fuh Yong Wong Wei Ying Tham Wen Long Nei Cindy Lim Hui Miao | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | A numerical assessment of two geometries for reducing elbow erosion显示文摘Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed particles.There are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged tee.Another option,although less commonly used,is the vortex-chamber elbow.In both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating conditions.The present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged tee.Simulations are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion reduction.The analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe fitting.In general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of erosion.On the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading conditions.Furthermore,the advantages and disadvantages of each fitting are highlighted. | Carlos Antonio Ribeiro Duarte Francisco Joséde Souza Diego Nei Venturi Martin Sommerfeld | 2020 | Particuology2020，18，2： | 3 |
| 3 | The theory of genetic distance and evolution of human races显示文摘 | Masatoshi Nei | 1978 | The Japanese Journal of Human Genetics1978，，4： | 2 |
| 4 | MEGA4:Molecular Evolutionary Genetics Analysis(MEGA)software version 4.0显示文摘 | Tamura K Dudley J Nei M Kumar S | | 0，，： | 2 |
| 5 | Estimation of average heterozygosity and genetic distance from a small number of individuals显示文摘 | Nei M | 1978 | Genetics1978，89，： | 2 |
| 6 | Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene显示文摘Primary torsion dystonia (PTD) is a clinically and genetically heterogeneous movement disorder. At least thirteen different types of dystonia can be distinguished on a genetic basis.1 The DYT1 gene was first mapped by Ozelius et al in 1989.2 (Kramer et) al3 linked the same locus to PTD in 12 Ashkenazi Jewish families in 1990. Most patients with early-onset generalized PTD were caused by the same three base pair (GAG) deletion in the DYT1 gene on chromosome 9q34.1,4,5 The product of the gene is a protein called torsinA.5 (Although the) function of this protein is as yet uncertain, it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones. | YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG Chun Nei TSE Ka Ming FOK Tai Fai | 2005 | Chinese Medical Journal2005，，10： | 2 |
| 7 | Mathematical model for study genetic variation in terms of restriction endonucleases 显示文摘 | Nei M Li WH | 1979 | Proc Natl Acad Sci USA1979，76，： | 2 |
| 8 | Estimation of average heterozygosity and genetic distance from a small number of individual 显示文摘 | Nei M | 1978 | Genetics1978，89，： | 2 |
| 9 | Effective and simple recovery of 1,3-propanediol from a fermented medium by liquid–liquid extraction system with ethanol and K_3PO_4显示文摘1,3-Propanediol,traditionally obtained from fossils,has numerous industrial applications,including use in the production of high performance polymers.The microbial production of 1,3-propanediol presents several opportunities,and the final purity grade determines its price and commercial viability.The development of novel separation technology could improve the economic viability of the bioproduction of 1,3-propanediol.Thus,we investigated salting-out extraction as a novel process for 1,3-propanediol recovery from fermentation broth.Initially,a screening for the best salt/solvent combination was conducted and then optimized using the response surface methodology.The solvents studied were methanol,ethanol,isopropanol and acetone,and the salts examined were K_2HPO_4,Na_2CO_3,K_2CO_3,(NH_4)_2SO_4,NaHPO_4,K_3PO_4 and C_6H_5NaO_7.The optimal extraction system consisted of 34 wt%K_3PO_4,28 wt% ethanol,and 38 wt% fermentation broth containing 23.0 g·L^(-1)1,3-propanediol,which gave the highest partition coefficient of 33 and recovery yield of 97%.The results demonstrated that salting-out extraction was a promising method for 1,3-propanediol recovery from fermentation broth. | Daiana Wischral Hongxin Fu Fernando L.Pellegrini Pessoa Nei Pereira Jr Shang-Tian Yang | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 2 |
| 10 | A Study of Spatial Variability on Aquifer Hydraulic Conductivity K显示文摘A structural analysis of K of an aquifer system in the study area is presented, and the main direction and degree of the variability of K are found by using the unstationary regionalized variable theory of geostatistics. Optimal estimation of K has been made by universal kriging method (U K M ). Both spatial variability distribution map and division map of K are given. | Chaolunbagen, Hetai and Liu TingxiDept. of Water Conservancy, Inner M ongolia College of Agriculture and Animal Husbandry, Hohhot, Nei M ongol Shang Ruoyun | 1995 | Acta Geologica Sinica(English Edition)1995，69，2： | 2 |
| 11 | History of Paleoseismic ActivityAlong the Hohhot Segment of Daqingshan Piedmont Fault in the Late Quaternary显示文摘A detailed study on geomorphic surfaces and a set of trenches on the Hohhot segment of Daqingshan piedmont fault at three sites, Kuisu, Ulan Blang, and Qingshan Grassland, revealed 7 paleoseismic events occurred along the fault segment since 19 ka BP. Those events occurred at 18.75±.75 ka, 16.97 ±.96 ka, 14.65±.67 ka, 11.82±.69 ka, 9.45±.26 ka, 6. 83±.26 ka, and 4. 50 ±0. 23 ka BP, respectively, and their average recurrence interval is 2375±432 years. From the results of constraining fault displacement and correlation between the sediments in these trenches, we found a complete paleoseismic activity history along the fault segment during this period of time. | Ran Yongkang and Zhang PeizhenInstitute of Geology, China Seismological Bureau, Beijing 100029, ChinaHu Bo and Guo WenshengSeismological Bureau of Nei Mongol Autonomous Region,Hohhot 010000, China | 2001 | Earthquake Research in China2001，15，2： | 2 |
| 12 | Ultrasonic waste activated sludge disintegration for improving anaerobic stabilization显示文摘 | A Tiehm K Nickel M Zellhorn U Neis | 2001 | Water Research2001，，8： | 2 |
| 13 | Estimation of average heterozygosity and genetic distance from a small number of indivldals显示文摘 | NEI M | 1978 | Genetics1978，89，： | 1 |
| 14 | The neighbor - joining method: a new method for reconstructing phylogenetic trees显示文摘 | Saitou N Nei M | 1987 | Molecular Biology and Evolution1987，4，： | 1 |
| 15 | A Review of Life Cycle Assessment ( LCA) on Some Food Products 显示文摘 | Roy P Nei D Orikasa T | 2009 | Journal of Food Engineering2009，90，1： | 1 |
| 16 | The neighbor-joining method: a new method for reconstructing phylogenetic trees 显示文摘 | Saitou N Nei M | 1987 | Mol Biol Evol1987，4，： | 1 |
| 17 | The neighbor-joining method:a new method for reconstructing phylogenetic trees显示文摘 | Saitou N Nei M | 1987 | Mol Biol Evol1987，4，4： | 1 |
| 18 | MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment显示文摘 | Kumar S Tamura K Nei M | 2004 | Brief Bioinform2004，，5： | 1 |
| 19 | MEGA3:Integrated soft-ware for molecular evolutionary genetics analysis and se-quence alignment显示文摘 | KUMAR S TAMURA K NEI M | 2004 | Bioinformatics2004，5，： | 1 |
| 20 | Relative efficiencies of the maximum parsimony and disentance matrix methods in obtaining the correct phylogenetic tree显示文摘 | SORDIS J NEI M | 1988 | Molecular Biology and evolution1988，5，： | 1 |
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