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    题名 作者 年代 出处 被引量
1Aeratednitrification in full-scale activated sludge facilities显示文摘Mervyn C Goronszy Gunnar Demoui Mark New Land 1997Wat Tech1997,35,10:1
2Dscl Vitamin D, calcium andprevention ofbreast cancer: a review 显示文摘Martin L Harold L New mark 1999Am Colle JNutr1999,5,18:1
3Finite element analysis of unicompartmental knee arthroplasty显示文摘Andrew R. Hopkins Andrew M. New Ferdinando Rodriguez-y-Baena Mark Taylor 2009Medical Engineering and Physics2009,,1:1
4Hematomas and Limb Skeletal Malformations in Chicken Embryos Following Exposure to 5-Fluoro-2'-Deoxyuridine显示文摘Vascular injury or interruption may play a role in vertebrate limb teratogenesis. Since 5fluoro- 2’- deoxyuridine (FdU) can cause vascular injury in the murine limb and skull prior to the appearance of skeletal malformations in these structures, we studied the effects of this chemical on skeletal development in the chick embryo and noted any vascular injury. The yolk sacs of day three ehick embryos (Hamburger and Hamilton states 17-19) were injected with solutions of vary concentrations of FdU in saline. The embryos developed until the 10th day of incubation when they were fixed for study. Uninjected, saline injected, and sham injected control embryo were similarly fixed. Upon gross inspection, frequent diffuse and saccular hernatomas, as well as fluid-filled blisters, were noted in the limbs of embryos treated with FdU. After the embryos were fixed and cleared, and the skeletons stained, significant skeletal malformations were observed in these limbs. Bony elements of both the upper and lower limbs were affected in at least some of the embryos. The combination of FdU-induced hematomas and blisters with associated skeletal malformations in the same regions of some embryos suggests a relationship between these phenomena.ROBERT S. NOLAN GARRY SCHWARTZ SEAN FARQUHARSON DAVID R.HOOTNICK E. MARK LEVINSOHN MARY MILLER LISA A. MANZ AND DAVID S. PACKARD, JR (Departments of Anatomy and Cell Biology, Orthopedic Surgery,and Pediatrics, State University of New York Health 1998Biomedical and Environmental Sciences1998,11,1:0
5Embryonic Hypertension Following Exposure to Teratogenic Doses of 5-Fluoro-2'-Deoxyuridine显示文摘The teratogenicity of 5-fluoro-2’-deoxyuridine (FdU) is well established. Previously, we have demonstrated that teratogenic doses of FdU produce hematomas and suggested that those hematomas produced skeletal malformations in chicken embryos. In this study, the cardiovascular effects of teratogenic doses of FdU in chicken embryos were studied. A dose of either 0.026 μg FdU or 0.030 μg FdU was injected into the yolk sacs of fertile chicken eggs containing embryos at Hamburger and Hamilton stages 17-19 of development. The embryos were then returned to the incubator. Aortic systolic and diastolic blood pressure,blood velocity and heart rate were measured at stages 21, 24 or 27 using a servonull system and Doppler ultrasound. In addition, mean arterial blood pressure, blood flow, and stroke volume were calculated from these data. Similar data were also recorded from uninjected and saline injected control embryos. Systolic and mean arterial blood pressures were significantly increased in FdU-treated embryos at stage 27. The other parameters measured or calculated were not significantly different from control embryos. Our study suggests that elevated systolic blood pressure in chicken embryos treated with FdU may lead to hematoma formation and subsequent birthVINU D. PATEL ROBERT S. NOLAN NORMAN HU EDWARD B. CLARKA DAVID R. HOOTNICK E. MARK LEVINSOHN AND DAVID S. PACKARD, JR.(Departments of Obstetrics and Gynecology, Anatomy and Cell Biotogy, and Pediatrics, Stale University of New York Health Science C 1996Biomedical and Environmental Sciences1996,9,4:0
6Molecular Dynamics Simulation of Dealloyed Layer-induced Tensile Stress in Cu_3Au显示文摘During stress corrosion cracking of Cu3Au alloy, there is a dealloyed layer on its surface because of preferential dissolution of Cu, and there is a linear distribution of Cu vacancy concentration in the dealloyed layer. Molecular dynamics simulation has been done on the three-dimensional crystal (about 14 8000 atomss) by employing the embedded-atom method (EAM) potential. Simulation shows that Cu3Au crystal in which there is a dealloyed layer on one surface and one end is fixed will be deflected after relaxing the a long time because of a tensile stress generated at or near the dealloyed layer interface. The deflection and then the tensile stress increase with increasing the depth of dealloyed layer and the vacancy concentration in the dealloyed layer.Qikai L, Yue Zhang, Mark Hoffman, Wuyang Chu 1)Materials Science and Engineering School. University of Science and Technology Beijing. Beijing 100083, China 2)School of Materials Science & Engineering, University of New South Wales, Sydney 2052, Austral 2001Journal of University of Science and Technology Beijing2001,8,4:0
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