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		题名	作者	年代	出处	被引量
	1	Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients.	José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho	2006	World Journal of Gastroenterology2006，12，45：	3
	2	Branching patterns and drainage territories of the middle hepatic vein in computersimulated right living-donor hepatectomies显示文摘	Neumann JO Thorn M Fischer L		0，，06：	1
	3	The segments of the hepatic veins--is there a spatial correlation to the Couin- aud liver segments? 显示文摘	Fischer L Thom M Neumann JO	2005	Eur J Radiol2005，53，2：	1
	4	The use of hyperventi-lation therapy after traumatic brain injury in Europe: an analysis ofthe BrainIT database 显示文摘	Neumann JO Chambers IR Citerio G	2008	Intensive Care Med2008，34，9：	1
	5	The segments of the hepatic veins-is there a spatial correlation to the Couinaud liv- er segments? 显示文摘	Fischer L Thorn M Neumann JO	2005	Eur J Radiol2005，53，2：	1
	6	Stereotactic biopsy anddrainage of a brainstem abscess caused by Listeriamonocytogenes显示文摘	Beynon C Neumann JO B-sel J	2013	Neurol Med Chir (Tokyo)2013，53，4：	1
	7	The segments of the hepatic veins-is there a spatial correlation to the Couinaud liver segments?显示文摘	Fischer L Thorn M Neumann JO	2005	Eur J Radiol2005，53，2：	1
	8	The segments of the hepatic veins-is there a spatial correlation to the Couinaud liver segments? 显示文摘	Fischer L Thorn M Neumann JO	2005	Eur J Radiol2005，53，2：	1

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