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	题名	作者	年代	出处	被引量
1	Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients.	José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho	2006	World Journal of Gastroenterology2006，12，45：	3
2	Viral myocarditis leading to cardiomyopathy: Do cytokines contribute to pat hogenesis显示文摘	Neumann DA Lane J R Allen GS	1993	Clin Immunol Immunopathol1993，68，：	1
3	Autoimmunity in myocarditis:models and mechanisms显示文摘	Rose NR Herskowitz A Neumann DA	1993	Clin Immunol Immunopathol1993，68，：	1
4	Induction ofmultiple heart autoantibodies in mice with coxsackievirusB3- and cardiac myosin-induced autoimmune myocarditis显示文摘	Neumann DA Rose NR Ansari AA	1994	J Immunol1994，152，1：	1
5	Gastric versus small-bowel tube feeding in the intensive care unit:a rospective comparison of efficacy显示文摘	Neumann DA De Legge MH	2002	Crit Care Med2002，30，7：	1
6	Unusual structure, phase transition, and dynamics of solid cubane 显示文摘	Yildirim T Gehring P M Neumann DA	1997	Phys Rev Lett1997，78，：	1
7	Viral myocarditis leading to cardiomyopathy: do cytokines contribute to pathogensis?显示文摘	Neumann DA Lane JR Allen GS	1993	Clin Immunol Immunopathol1993，68，2：	1
8	Gastric versus small-bowel tube feeding in the intensive care unit: a prospective comparson of efficacy 显示文摘	Neumann DA Delegge MH	2002	Crit Care Med2002，30，7：	1
9	Interleukin 1 or tumor necrosis factor can promote coxsackieB3 - induced myocarditis in resistant B10 显示文摘	Lane JR Neumann DA Lafond - Walker A	1992	A mice1992，175，：	1
10	An electromyographic analysis of the hip abductors during load carriage : implications for hip joint protection 显示文摘	Neumann DA Hase AD	1994	J Orthop Sports Phys Ther1994，5，：	1
11	Role of IgG-seropositivity to Chlamydia pneumoniae in early thrombotic events after coronary stent placement显示文摘	Prazeres da Costa C Neumann FJ Kastrati A	2003	Atherosclerosis2003，166，1：	1
12	Induction of multiple heart autoantibodies in mice with coxsackievirus B3 and cardiac myosin-induced autoimmune myocarditis显示文摘	Neumann DA Rose NR Ansari AA	1994	J Immunol1994，152，：	1
13	Oxytocin and major depressive disorder:experimental and clinical evidence for links to aetiology and possibletreatment显示文摘	Slattery DA Neumann ID	2010	Pharmaceuticals2010，3，：	1
14	Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy显示文摘	Neumann DA Burek CL Baughman KL	1990	J Am Coll Cardiol1990，16，6：	1
15	Heart-specific autoantibodies can be eluted from the hearts of Coxsackievirus B3-infected mice显示文摘	Neumann DA Lane JR La Fond-Walker A	1991	Clin Exp Immunol1991，86，3：	1
16	Induction of multiple heart autoantibodies in mice with coxsackievirus B3-and cardiac myosin-induced autoimmune myocarditis显示文摘	Neumann DA Rose NR Ansari AA	1994	J Immunol1994，152，1：	1
17	Induction of multiple heart autoantibodies in mice with coxsackievirus B3-and cardiac myosin-induced autoimmune myocarditis显示文摘	DA Neumann NR Rose A Herskowitz	1994	J Immunol1994，152，：	1
18	Autoimmune myocarditis:a paradigm of post-infection autoimmune disease显示文摘	Rose NR Herskowitz A Neumann DA	1988	Immunol Today1988，9，4：	1
19	Liver transplant-ation for primarybiliary cirrhosis: retrospective an-alysisofresuhs atasingle center显示文摘	Jacob DA Neumann UP Bahra M	2006	Deutsche Medizini-sche Wochenschrift2006，131，42：	1
20	Syndesmotic ankle sprains显示文摘	Boytim M J Fischr DA Neumann L	2012	Am J Sports Med2012，31，3：	1

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