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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Influence of the projectiles' mate- rial in a coilgun 显示文摘 | HINAJE M NETTER D | 2006 | European Journal of Physics2006，27，1： | 1 |
| 3 | Fatigue life prediction of a railway bogie under dynamic loads through simula- tion显示文摘 | Dietz S Netter H Sachau D | 1998 | Vehicle System Dynamics1998，29，6： | 1 |
| 4 | Establishment of a reliable method for direct proteome characterization of human articular cartilage显示文摘 | Vincourt JB Lionneton F Kratassiouk G Guillemin F Netter P Mainard D Magdalou J | 2006 | Mol Cell Proteomics2006，，5： | 1 |
| 5 | Influence of the projectiles' ma- terial in a coilgun显示文摘 | HINAJE M NETTER D | 2012 | European Journal of Physics2012，27，1： | 1 |
| 6 | Fatigue Life Predic- tion of Railway Bogie under Dynamic Loads Through Simulation显示文摘 | Dietz S Netter H Sachau D | 1998 | Vehicle System Dynamics1998，29，6： | 1 |
| 7 | Effects of nucleotide change on the ability of hepatitis delta virus to transcribe, process, and accumulate unit-length, circular RNA显示文摘 | Wu T T Netter H J Lazinski D W | 1997 | J Virol1997，71，： | 1 |
| 8 | Fatigue life prediction of a railway bogie under dynamic loads through simulation显示文摘 | DIETZ S NETTER H SACHAU D | 1998 | Vehicle System Dynamics1998，29，6： | 1 |
| 9 | Fatigue life prediction of a railway bogie under dynamic loads through simulation显示文摘 | Dietz S Netter H Sachau D | 1998 | Vehicle System Dynamics1998，29，： | 1 |
| 10 | Influence of the projectiles' material in a coilgun 显示文摘 | Hinaje M Netter D | 2006 | European Journal of Physics2006，27，： | 1 |
| 11 | Fatigue life prediction of a railway bogie under dynamic loads through simulation显示文摘 | Dietz S Netter H Sachau D | 1998 | Vehicle System Dynamics1998，29，6： | 1 |
| 12 | Fatigue Life Prediction of a Railway Bogie under Dynamic Load through Simulation显示文摘 | Stefan D Netter H Sachau D | 1998 | Vehicle System Dynamics1998，29，： | 1 |
| 13 | The peroxisome proliferator-activated receptor gamma agonist pioglitazone preserves bone microarchitecture in experimental arthritis by reducing the interleukin-17-dependent osteoclastogenic pathway显示文摘 | Koufany M Chappard D Netter P | 2013 | Arthritis Rheum2013，65，12： | 1 |
| 14 | Fatigue life prediction of a railway bogie under dynamic loads through simulation显示文摘 | DIETZ S NETTER H SACHAU D | 1998 | Vehicle System Dynamics1998，29，3： | 1 |
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