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| 1 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 2 | Tip grafts in closed rhiiloplasty:insertion and fixation made easy显示文摘 | FERNANDEZ D E da SIL VA CARVALHO G | 2008 | Plast Reconstr Surg2008，121，3： | 1 |
| 3 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 4 | Intensified fuzzy clusters for classifying plant, soil, and residue regions of interest from color images显示文摘 | Meyer G E Neto J C Jones D D | 2004 | Computers and Electronics in Agriculture2004，42，3： | 1 |
| 5 | Rapid silver stainingand recovery of PCR products separated on polyacrylamide gels显示文摘 | SANGUINETTI C J NETO E D SIMPSON A J G | 1994 | Bio-techniques1994，17，5： | 1 |
| 6 | Plant species identifica- tion using elliptic fourier leaf shape analysis显示文摘 | Neto J C Meyer G E Jones D D | 2006 | Computers and E- lectronics in Agriculture2006，50，2： | 1 |
| 7 | Geotechnical influence on the acoustic properties of marinesediments of the Santos Basin, Brazil显示文摘 | NETO A A MENDES J D T DE SOUZA J M G 2013 | 2013 | Marine Georesources& Geotechnology2013，31，2： | 1 |
| 8 | Programmable optical phase-mostly holograms with coupled-mode modulation liquid-crystal television显示文摘 | NETO L G ROBERGE D SHANG Y L | 1995 | Appl Opt1995，34，11： | 1 |
| 9 | Mutations of the KISSI Gene in Disorders of Puberty 显示文摘 | SILVEIRA L G NOEL S D SILVEIRA NETO A P | 2010 | J Clin Endocrinol Metab2010，959，5： | 1 |
| 10 | Intensified fuzzy clusters for classifying plant,soil,and residue regions of interest from color images显示文摘 | Meyer G E Camargo Neto J Jones D D | 2004 | Computers and Electronics in Agriculture2004，42，3： | 1 |
| 11 | Comparative modeling and QM/MM studies of cysteine protease mutant of Theobroma cacao显示文摘 | ANDRADE D V G D GOES NETO A JUNIOR M C et al | 2012 | Int J Quantum Chem2012，112，19： | 1 |
| 12 | Intensified fuzzy clusters for classifying plant,soil and residue regions of interest from color images显示文摘 | Meyer G E Neto J C Jones D D | 2004 | Computers and Electronics in Agriculture2004，42，3： | 1 |
| 13 | PdBi/C electrocatalysts for ethanol electro-oxidation in alkaline medium显示文摘 | NETO A O TUSI M M DE OLIVEIRA POLANCO N S DA SILVAA S G SANTOSB M C D SPINACé E V | 2011 | Int J Hydrogen Energy2011，36，10： | 1 |
| 14 | Photophysical and electrochemical properties ofπ-extended molecular 2,1,3-benzothiadiazoles显示文摘 | NETO B A D LOPES A S EBELING G | 2005 | Tetrahedron2005，61，10： | 1 |
| 15 | PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S 180 micro- satellite in sporadic and inherited human basal cell carcinomas显示文摘 | Santos D C Zaphiropoulos P G Neto C F | 2011 | Int J Dermatol2011，50，7： | 1 |
| 16 | Photophysical and electrochemical properties of π-extended molecular 2, 1, 3-benzothiadiazoles 显示文摘 | Neto B A D Lopes A S Ebeling G | 2005 | Tetrahedron2005，61，10： | 1 |
| 17 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels 显示文摘 | Sanguinetti C J Neto E D Simpson A J G | 1994 | Bio Techniques1994，17，： | 1 |
| 18 | Intensified fuzzy clusters for classifying plant, soil, and residue regions of interest from color images显示文摘 | Meyer G E Camargo Neto J Jones D D | 2004 | Computers and Electronics in Agriculture2004，42，3： | 1 |
| 19 | Rapid silver staining and recovery of PCR products separated on polyaerylamide gels polymerase chain reaction produel recovery显示文摘 | Sanguinetti C J Neto E D Simpsor A G | 1994 | Biotech- niques1994，17，5： | 1 |
| 20 | Individual leaf extractions from young canopy images using Gustafson Kessel clustering and a genetic algorithrn显示文摘 | Neto J C M G E b Jones D D | 2006 | Computers and Electronics in Agriculture2006，51，： | 1 |
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