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| 1 | Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma显示文摘AIM: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC). METHODS: Archival tumor samples were analyzed for β-catenin using immunohistochemistry (IHC) in 95 patients with advanced CRC. RESULTS: Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression,and 55 (58%) cases showed nuclear expression. In univariate (Kaplan-Meier) survival analysis,only the nuclear index (NI) was a signifi cant predictor of disease-free survival (DFS) (P = 0.023; n = 35),with a NI above the median associated with longer DFS (34.2 mo) than those with a NI below the median (15.5 mo) (P = 0.045,ANOVA). The other indices were not significant predictors of DFS,and none of the three tested indices (for membranous,cytoplasmic,or nuclear expression) predicted disease-specific survival (DSS). However,when dichotomized as positive or negative nuclear expression,the former was a signifi cant predictor of more favorable DFS (P = 0.041) and DSS (P = 0.046). CONCLUSION: Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，24： | 13 |
| 2 | 脉搏波传导速度预测青年人血压进展与高血压发生显示文摘该研究旨在评估脉搏波传导速度(pulse wave velocity,PWV)是否能够预测青年人血压进展及高血压的发生,并探讨除传统心血管病危险因素外,PWV是否可改善高血压发生的风险预测。Koivistoinen等于2007年及2011年分别测量1449例芬兰成人(年龄30~45岁)的收缩压及舒张压水平。此外,于2007年还测定了其PWV及其他心血管病危险因素。 | Koivistoinen T Lyytik?inen LP Aatola H Luukkaala T Juonala M Viikari J Lehtim?ki T Raitakari OT K?h?nen M Hutri-K?h?nen N 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，1： | 12 |
| 3 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 4 | Lignin Biosynthesis Studies in Plant Tissue Cultures显示文摘Lignin, a phenolic polymer abundant in cell walls of certain cell types, has given challenges to scientists studying its structure or biosynthesis. In plants lignified tissues are distributed between other, non-lignified tissues. Characterization of native lignin in the cell wall has been difficult due to the highly cross-linked nature of the wall components. Model systems, like plant tissue cultures with tracheary element differentiation or extracellular lignin formation, have provided useful information related to lignin structure and several aspects of lignin formation. For example, many enzyme activities in the phenylpropanoid pathway have been first identified in tissue cultures. This review focuses on studies where the use of plant tissue cultures has been advantageous in structural and biosynthesis studies of lignin, and discusses the validity of tissue cultures as models for lignin biosynthesis. | Anna Krknen Sanna Koutaniemi | 2010 | Journal of Integrative Plant Biology2010，52，2： | 9 |
| 5 | Using Statistical Downscaling to Quantify the GCM-Related Uncertainty in Regional Climate Change Scenarios: A Case Study of Swedish Precipitation显示文摘有在地区性的气候变化情形的不确定性的很多来源。当统计 downscaling 被用来获得地区性的气候变化情形时,不确定性可以在使用的模型,统计模型的技巧,和强迫的情形用于世界气候模型的世界气候从不确定性发源。与世界气候模型联系的不确定性能被基于一套不同世界气候模型在预言者并且在 downscaled 气候变化情形检验差别评估。什么时候标准化了象 CoupledModel Intercomparison 工程(CMIP2 ) 的第二个阶段那样的世界气候模型模拟,被使用,在 downscaled 变量的差别主要在模仿的气候在气候模型和自然可变性反映差别。Itis 建议估计的传播能作为与世界气候模型联系的不确定性的一项措施被拿。建议方法在瑞典在地区性的降水变化情形被用于评价 ofglobal-climate-model-related 不确定性。尽管在降水的变化的可观的传播存在,基于在整个瑞典的年度降水有全面增加的 17 世界气候模型表演源于统计 downscaling。一般增加能被归因于增加的 large-scaleprecipitation 和提高的偏午。估计的不确定性将近独立于区域。然而,有季节的依赖。为冬季的估计显示出信心的高水平,当为夏天的估计最不出现时。 | Deliang CHEN Christine ACHBERGER Jouni R■IS■NEN Cecilia HELLSTRM | 2006 | Advances in Atmospheric Sciences2006，23，1： | 9 |
| 6 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 7 | MR电影成像验证早期家族性扩张型心肌病的状态参数显示文摘目的运用MRI显示核纤层蛋白A/C基因(LMNA)突变携带者心脏解剖结构和功能早期变化的特征,并建立一种分析和显示结果的工具。 | J.R.Koikkalainen M.Antila J.M.P.Ltjnen T.Heli K.Lauerma S.M.Kivist 周路遥 | 2008 | 国际医学放射学杂志2008，31，A06： | 7 |
| 8 | Low circulating levels of gastrin-17 in patients with Barrett's esophagus显示文摘AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls. | Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen | 2005 | World Journal of Gastroenterology2005，11，38： | 6 |
| 9 | 雌激素通过调节骨髓来源的成骨细胞所产生的细胞因子抑制破骨细胞功能显示文摘目的 通过观察雌激素对骨髓来源的成骨细胞所产生的细胞因子的调节作用 ,探讨雌激素抑制破骨细胞功能的机制。方法 在诱导小鼠骨髓细胞分化为成骨细胞后 ,于成骨细胞培养中加入雌激素 ,应用抗体荧光免疫标记法检测成骨细胞培养液中IL 1,IL 6和TNF α水平。结果与对照组比较 ,经 0 0 1~ 1nM雌激素处理后 ,成骨细胞所产生的IL 1和IL 6水平呈浓度依赖性下降 ,TNF α水平则无明显变化。结论 雌激素具有调节成骨细胞分泌细胞因子功能 。 | 曲强 万新海 陈翠珠 Vnnen HK | 2002 | 中国骨质疏松杂志2002，8，1： | 6 |
| 10 | Toremifene in the treatment of breast cancer显示文摘Although more widespread screening and routine adjuvant therapy has improved the outcome for breast cancer patients in recent years, there remains considerable scope for improving the efficacy, safety and tolerability of adjuvant therapy in the early stage disease and the treatment of advanced disease. Toremifene is a selective estrogen receptor modifier(SERM) that has been widely used for decades in hormone receptor positive breast cancer both in early and late stage disease. Its efficacy has been well established in nine prospective randomized phase Ⅲ trials compared to tamoxifen involving more than 5500 patients, as well as in several large uncontrolled and non-randomized studies. Although most studies show therapeutic equivalence between the two SERMs, some show an advantage for toremifene. Several meta-analyses have also confirmed that the efficacy of toremifene is at least as good as that of tamoxifen. In terms of safety and tolerability toremifene is broadly similar to tamoxifen although there is some evidence that toremifene is less likely to cause uterine neoplasms, serious vascular events andit has a more positive effect on serum lipids than does tamoxifen. Toremifene is therefore effective and safe in the treatment of breast cancer. It provides not only a useful therapeutic alternative to tamoxifen, but may bring specific benefits. | Mika VJ Mustonen Seppo Pyrh?nen Pirkko-Liisa Kellokumpu-Lehtinen | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 11 | 内部营养盐通量抵消了外部排放量的下降:波罗的海芬兰湾东部河口海区的案例分析显示文摘尽管外部营养盐的输入量下降了约30%,但在芬兰湾的开阔海区并没有出现相应的改善。20世纪90年代末向芬兰湾中的氮排放量达到了每年120000t,而每年磷的排放量为7000t。就其表面水域而言,芬兰湾海区营养盐的单位面积排放量是整个波罗的海营养盐平均单位面积排放量的2~3倍。尽管排放量有所下降,但在20世纪90年代中期海表和近海底的水域中磷酸盐的浓度仍呈上升趋势。导致这种状况发生的主要原因可能是20世纪90年代芬兰湾东部海域沉积物与水的交界处氧气状况的恶化导致了内部营养盐排放的增多,但20世纪80年代和90年代初期这一海区的供氧状况相对较好。根据在芬兰湾近海获取的实验数据,表层沉积物和水之间的磷酸盐-磷的通量已减少到平均值,13kg/km^2·d。这与在波兰湾开阔海区测量到的能够代表其变化趋势的磷含量相符。沉积物流出物中氮和磷的低比率在一定程度上解释了芬兰湾的初级生产中氮受到的限制。 | HeikkiPitknen JouniLehtoranta AnttiRike 许天虎 | 2001 | AMBIO-人类环境杂志2001，30，4： | 5 |
| 12 | Cytokines in the BALB/c mouse testis in various conditions显示文摘To investigate whether testosterone, estrogens, vasectomy, experimental cryptorchidism, varicocele or aging would induce changes in the cytokine environment of the mouse testis. Methods: In adult male BALB/c mice,testosterone implants, estradiol benzoate, vasectomy, unilateral cryptorchidism, unilateral varicocele were adminis tered/performed. The mice were followed up for different periods of time and were then sacrificed with testes incised for examination. The control mice received the vehicle or sham-operation. Results: IL-10 was present in Leydig cells of nearly every testis and IL-10 + macrophages in 39% of testes. IL-6 was found in the testes of intact adult mice, mice treated with testosterone for 70 days, cryptorchid testes and sham-operated testes. Conclusion: Results suggest that IL-10 might be involved in the generation of the immunologically privileged microenvironment in the testis. | E.Verjnkorva M.Martikainen P.Pllnen | 2001 | Asian Journal of Andrology2001，3，1： | 4 |
| 13 | CFD simulations of gas-solid flow in an industrial-scale circulating fluidized bed furnace using subgrid-scale drag models显示文摘Mesoscale flow structures such as clusters and streamers of particles are characteristic features of gas-solid flow in fluidized beds.Numerical simulations of gas-solid flows for industrial-scale fluidized beds are often performed using the Eulerian description of phases.An accurate prediction of this type of flow structure using the Eulerian modeling approach requires a sufficiently fine mesh resolution.Because of the long computational time required when using fine meshes,simulations of industrial-sized units are usually conducted using coarse meshes,which cannot resolve the mesoscale flow structures.This leads to an overestimation of the gas-solid drag force and a false prediction of the flow field.For these cases,a correction must be formulated for the gas-solid drag.We have simulated a large-scale circulating fluidized bed furnace using different gas-solid drag models and compared the model results with measurements. | Srujal Shah Kari My?h?nen Sirpa Kallio Timo Hypp?nen | 2015 | Particuology2015，13，1： | 4 |
| 14 | Norway spruce(Picea abies) laccases:Characterization of a laccase in a lignin-forming tissue culture显示文摘Secondarily thickened cell walls of water-conducting vessels and tracheids and support-giving sclerenchyma cells contain lignin that makes the cell wal s water impermeable and strong. To what extent laccases and peroxidases contribute to lignin biosynthesis in muro is under active evaluation. We performed an in silico study of Norway spruce(Picea abies(L.)Karst.) laccases utilizing available genomic data. As many as 292 laccase encoding sequences(genes, gene fragments, and pseudogenes) were detected in the spruce genome. Out of the 112 genes annotated as laccases, 79 are expressed at some level. We isolated five full-length laccase c DNAs from developing xylem and an extracellular lignin-forming cell culture of spruce. In addition, we purified and biochemically characterized one culture medium laccase from the lignin-forming cell culture.This laccase has an acidic p H optimum(p H 3.8–4.2) for coniferyl alcohol oxidation. It has a high af finity to coniferyl alcohol with an apparent K m value of 3.5 m M; however, the laccase has a lowe catalytic ef ficiency(V max/K m) for coniferyl alcohol oxidation compared with some purified culture medium peroxidases. The properties are discussed in the context of the information already known about laccases/coniferyl alcohol oxidases o coniferous plants. | Sanna Koutaniemi Heli A.Malmberg Liisa K.Simola Teemu H.Teeri Anna K?rk?nen | 2015 | Journal of Integrative Plant Biology2015，57，4： | 4 |
| 15 | 冷战和环境:芬兰在波罗的海地区国际环境政治方面的角色显示文摘1974年在赫尔辛基签署的关于《波罗的海区域海洋环境保护公约》可能是在波罗的海地区最重要的环境保护协议。本篇文章是首次运用原始档案资料第一次探究本公约的历史,也称之为《赫尔辛基公约》。这些原始资料主要出自芬兰外交部的档案。我们从国际政治角度研究了《赫尔辛基公约》整个签署的过程中芬兰的作用。本研究主要集中在芬兰、瑞典和苏联从20世纪60年代末到1974年的国家政党。我们表明,冷战政治从若干方面影响《赫尔辛基公约》的谈判和内容。我们也认为苏联利用新出现的国际环境问题作为一种新的强权政治的工具。 | Tuomas Rsnen Simo Laakkonen 翟伟康 | 2007 | AMBIO-人类环境杂志2007，36，2： | 4 |
| 16 | 北方沼泽地水位下降对全球气候变暖的影响显示文摘自从最后一次冰川消退以来,北方沼泽地(3.46亿hm^2)积存了300~500Pg碳。这些沼泽地在分离二氧化碳(CO_2)的同时,释放了相当数量的甲烷(CH_4)到大气中。正如对高纬地区预报的那样,如果夏季变得更热、更干,未来沼泽地温室气体的平衡将发生变化,随之而来的CH_4排放将减少,而CO_2和N_2O的排放将增加。北部沼泽地水位下降预计将增强温室效应的影响。我们分别在不同营养水平的未排水和排水的沼泽地测量了碳循环的组分,并把这些结果归纳成一个简单的辐射强迫因子,用以评价水位下降对大气的综合影响。在对存于土壤和树木中的碳以及为经营森林而排水引起的水位下降后CO_2、CH_4和N_2O的通量的变化作出测量的基础上,我们提出一个假设,即由气候变化引发的干旱趋势将减弱北方沼泽地对总辐射强迫的影响,这一影响在100年内约为0.1W/m^2。CH_4排放的减少,沼泽地碳储量的微小变化和树木生物量储存的增加都将导致这一变化。 | Jukka Laine Jouko Silvola Kimmo Tolonen Jukka Alm Hannu Nyknen Harri Vasander Tapani Sallantaus Ilkka Savolainen Jukka Sinisalo Pertti J.Martikainen 钱云 | 1996 | 人类环境杂志1996，25，3： | 4 |
| 17 | 海冰热力模式的辐射参数化方案在渤海和波罗的海应用的比较显示文摘研究了海冰热力模式中的各种辐射参数化方案,对比了模式计算的太阳短波辐射、大气长波辐射以及海冰热力变化,并利用渤海和波罗的海观测资料进行比较和误差分析.冬季大部分时间太阳短波辐射对海冰热力过程的作用有限.简单计算方案一般满足海冰模式要求.误差主要受云和冰雪表面与大气之间的多重反射影响.长波辐射对表面热平衡和海冰质量变化起重要作用.长波辐射参数化方案的计算结果受环境因素影响.云量参数化有待进一步改进.海冰模式计算结果的精度与长波辐射计算精度有一致性. | 张占海 程斌 LAUNIAI NEN Jouko 吴辉碇 刘煜 | 2006 | 海洋学报2006，28，4： | 4 |
| 18 | Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma显示文摘AIM:To correlate cyclooxygenase-2(COX-2)expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma(CRC).METHODS:Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with CRC.Patients were diagnosed and treatedat the Departments of Surgery and Oncology,King Abdulaziz University Hospital,Saudi Arabia.RESULTS:Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression,whereas 44%of cases were completely COX-2-negative.There were no significant correlations between COX-2 expression and sex,age,grade or tumor location.However,COX-2 expression revealed a significant correlation with tumor stage(P=0.01)and distant metastasis(P=0.02),and a borderline association with lymph node involvement(P =0.07).Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression(P<0.009).In univariate Kaplan-Meier survival analysis,there was a significant(P=0.026)difference in disease-free survival between COX-2-positive and negative tumors in favor of the latter.COX-2 expression did not significantly predict disease-specific survival,which was much shorter for COX-2-positive tumors.In multivariate(COX)models,COX-2 did not appear among the independent predictors of disease-free survival or disease-specific survival.CONCLUSION:COX-2 expression seems to provide useful prognostic information in CRC,while predicting the patients at high risk for recurrent disease. | Jaudah Al-Maghrabi Abdelbaset Buhmeida Eman Emam Kari Syrjnen Abdulrahman Sibiany Mohmmad Al-Qahtani Mahmoud Al-Ahwal | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 19 | Additive QTLs on three chromosomes control flowering time in woodland strawberry(Fragaria vesca L.)显示文摘Flowering time is an important trait that affects survival,reproduction and yield in both wild and cultivated plants.Therefore,many studies have focused on the identification of flowering time quantitative trait locus(QTLs)in different crops,and molecular control of this trait has been extensively investigated in model species.Here we report the mapping of QTLs for flowering time and vegetative traits in a large woodland strawberry mapping population that was phenotyped both under field conditions and in a greenhouse after flower induction in the field.The greenhouse experiment revealed additive QTLs in three linkage groups(LG),two on both LG4 and LG7,and one on LG6 that explain about half of the flowering time variance in the population.Three of the QTLs were newly identified in this study,and one co-localized with the previously characterized FvTFL1 gene.An additional strong QTL corresponding to previously mapped PFRU was detected in both field and greenhouse experiments indicating that gene(s)in this locus can control the timing of flowering in different environments in addition to the duration of flowering and axillary bud differentiation to runners and branch crowns.Several putative flowering time genes were identified in these QTL regions that await functional validation.Our results indicate that a few major QTLs may control flowering time and axillary bud differentiation in strawberries.We suggest that the identification of causal genes in the diploid strawberry may enable fine tuning of flowering time and vegetative growth in the closely related octoploid cultivated strawberry. | Samia Samad Takeshi Kurokura Elli Koskela Tuomas Toivainen Vipul Patel Katriina Mouhu Daniel James Sargent Timo Hytönen | 2017 | Horticulture Research2017，4，1： | 3 |
| 20 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
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