|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 3 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 4 | Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs. | Cristiana Pistol Tanase Ana Iulia Neagu Laura Georgiana Necula Cristina Mambet Ana-Maria Enciu Bogdan Calenic Maria Linda Cruceru Radu Albulescu | 2014 | World Journal of Gastroenterology2014，20，31： | 4 |
| 5 | Murine models based on acute myeloid leukemia-initiating stem cells xenografting显示文摘Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop 'humanized mice' that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models. | Cristina Mambet Mihaela Chivu-Economescu Lilia Matei Laura Georgiana Necula Denisa Laura Dragu Coralia Bleotu Carmen Cristina Diaconu | 2018 | World Journal of Stem Cells2018，10，6： | 2 |
| 6 | An electron microscopical study on the growth of TiO 2 –Ag antibacterial coatings on Ti6Al7Nb biomedical alloy显示文摘 | B.S. Necula I. Apachitei F.D. Tichelaar L.E. Fratila-Apachitei J. Duszczyk | 2011 | Acta Biomaterialia2011，，6： | 2 |
| 7 | Enrichment of anodic MgO layers with Ag nanoparticles for biomedical applications显示文摘 | B. S. Necula L. E. Fratila-Apachitei A. Berkani I. Apachitei J. Duszczyk | 2009 | Journal of Materials Science: Materials in Medicine2009，，1： | 2 |
| 8 | Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct 显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 9 | CIL: Intermediate Language and Tools for Analysis and Transformation of C Programs显示文摘 | Necula G C McPeak S Rahul S R | 2002 | Lecture Notes in Computer Science2002，2304，： | 1 |
| 10 | Option pricing in a f ractional Brownian motion environment显示文摘 | Ciprian Necula | 2002 | Pure Mathematics2002，2，1： | 1 |
| 11 | Option pricing in a fractional Brownian motion environment显示文摘 | Necula C | 2002 | Preprint2002，，18： | 1 |
| 12 | Cathode priming of a relativistic magnetron显示文摘 | Jones M C Neculaes V B Lau Y Y | 2004 | Appl Phys Lett2004，85，26： | 1 |
| 13 | Low-noise microwave magnetrons by azimuthally varying axial magnetic field显示文摘 | Neculaes V B Gilgenbach R M Lau Y Y | 2003 | Appl Phys Lett2003，83，10： | 1 |
| 14 | Low-noise microwave oven magnetrons with fast start-oscillations by azimuthally varying axial magnetic field显示文摘 | Neculaes V B Gilgenbach R M Lau Y Y | 2004 | IEEE Trans Plasma Sci2004，32，3： | 1 |
| 15 | Option pricing in a fractional Brownian motion environment显示文摘 | Necula C | 2002 | Preprint2002，，18： | 1 |
| 16 | Simulation of rapid startup in microwave magnetrons with azimuthally-varying axial magnetic field显示文摘 | Jones M C Neculaes V B White W M | 2004 | Appl Phys Lett2004，84，6： | 1 |
| 17 | Option Pricing in a Fractional Brownian Motion Environment显示文摘 | Necula C | 2004 | Mathematical Reports2004，6，3： | 1 |
| 18 | Option pricing in a fractional Brownian motion environment显示文摘 | Ciprian Necula | 2002 | Pure Mathematics2002，2，1： | 1 |
| 19 | Epigenetics in gastric carcinogenesis : tet genes as important players 显示文摘 | Necula LG Mambet C Albulescu R | 2015 | J Immunoassay Immunochem2015，36，5： | 1 |
| 20 | An electron microscopical study on the growth of TiO2-Ag antibacterial coatings on Ti6A17Nb biomedical alloy显示文摘 | NECULA B S APACHITEI L TICHELAAR F D | 2011 | Acta Biomaterialia2011，7，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员