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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | Knockout mouse models of insulin signaling: Relevance past and future显示文摘Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, re searchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research much has been learned, but the pathophysiology o insulin resistance in human diabetes remains contro versial, and treating insulin resistance remains a chal lenge. This review will discuss limitations of mouse models lacking select insulin signaling molecule genes In the most influential mouse models, glucose metabo lism differs from that of humans at the cellular, organ and whole-organism levels, and these differences limi the relevance and benefit of the mouse models both in terms of mechanistic investigations and therapeutic development. These differences are due partly to im mutable differences in mouse and human biology, and partly to the failure of genetic modifications to produce an accurate model of human diabetes. Several fac tors often limit the mechanistic insights gained from experimental mice to the particular species and strain including: developmental effects, unexpected meta bolic adjustments, genetic background effects, and technical issues. We conclude that the limitations and weaknesses of genetically modified mouse models of insulin resistance underscore the need for redirection of research efforts toward methods that are more directly relevant to human physiology. | Anne E Bunner P Charukeshi Chandrasekera Neal D Barnard | 2014 | World Journal of Diabetes2014，5，2： | 9 |
| 3 | Impact of the suction line accumulator on the frost/defrost performance of an air-source heat pump with a scroll compressor显示文摘 | Nutter D W O'Neal D L Payne W V | 1996 | ASHRAE Transaction1996，102，1： | 4 |
| 4 | Effect of short-tube orifice size on the performance of an air source heatpump during the reverse-cycle defrost显示文摘 | O'Neal D L Pterson K T Anand N K | 1991 | Int J Refrig1991，14，7： | 4 |
| 5 | Refrigeration system dynamics during the reverse cycle defrost显示文摘 | O'Neal D L Pterson K T Anand N K | 1989 | ASHRAE Transaction1989，95，2： | 2 |
| 6 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 7 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 8 | Relationship of campylobacter toxigenicity in vitro to the development of post-infectious irritable bowel syndrome显示文摘 | Jenkins D Neal K | 2001 | J Infect Dis2001，184，5： | 1 |
| 9 | A review of frost fromation in simple geometries显示文摘 | | 1985 | ASHRAE1985，91，26： | 1 |
| 10 | Nucleotide diversity and linkage disequilibrium in cold-hardiness- and wood qual- ity-related candidate genes in douglas fir显示文摘 | KRUTOVSKY K V NEALE D B | 2005 | Genetics2005，171，4： | 1 |
| 11 | Near Shannon limit performance of low density parity check codes 显示文摘 | MACKAY D J C NEAL R M | 1997 | Electronics Letters1997，33，6： | 1 |
| 12 | Near Shannon limit performance of low density parity check codes 显示文摘 | Mackay D J C Neal R M | 1996 | Electronics Letters1996，33，6： | 1 |
| 13 | CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil ver- sus vancomycin plus aztreonam in treatment of acute bacterialskin and skin structure infections 显示文摘 | Friedland HD O' Neal T Biek D | 2012 | Antimicrub Agents Chemother2012，56，5： | 1 |
| 14 | Benign prostatic hyperplasia显示文摘 | Thorpe A Neal D | 2003 | Lancet2003，361，9366： | 1 |
| 15 | Nucleotide diversity and linkage disequilibrium in cold-hardiness and wood quality-related candidate genes in Douglas fir 显示文摘 | KRUTOVSKY K V NEALE D B | 2005 | Genet- ics2005，171，4： | 1 |
| 16 | Near Shannon limit performance of low density parity check codes显示文摘 | MACKAY D J C and NEAL R M | 1996 | Electronics Letters1996，32，18： | 1 |
| 17 | Comparative analysis of flow eytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia显示文摘 | Neale GA Coustan-Smith E Stow P Pan Q Chen X Pui CH Campana D | 2004 | Leukemia2004，18，5： | 1 |
| 18 | Detection of minimal residual disease in acute lymphoblastic leukemia:The St Jude experience 显示文摘 | Campana D Neale GA Coustan - Smith E | 2001 | Leukemia2001，15，2： | 1 |
| 19 | Development of an equivalent diameter expression for vertical U-tube used in ground - coupled heat pumps 显示文摘 | GU Y O' NEAL D L | 1998 | ASHRAE Transactions1998，，2： | 1 |
| 20 | Do adiponectin,TNF alpha,leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes,during and after pregnancy显示文摘 | McLachlan KA O'Neal D Jenkins A | 2006 | Diabetes Metab Res Rev2006，22，2： | 1 |
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