|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | 肝脏富血供肿瘤:低管电压、高管电流多层CT扫描在肝动脉晚期对肿瘤检出的初步临床经验显示文摘目的在个体内比较低管电压(80kV)、高管电流CT检查技术与标准CT扫描方案(140kV)检查时,在影像质量、辐射剂量及动脉晚期发现富血供恶性肝脏肿瘤等方面的不同。方法本项前瞻性符合HIPAA法案,单中心研究获机构伦理审查委员会批准,并签署知情同意书。48例(男性31例.女性17例,平均年龄35~77岁)病人的60个恶性富血供肝脏肿瘤病灶[平均直径(20.1±16.4)mm]人组。33个结节通过局部病灶的组织病理学分析获得证实,27个结节影像学随访至少12个月。病人接受双能64层螺旋CT检查。 | D. Marin R.C. Nelson E. Samei E.K. Paulson L.M. Ho D.T. Boll 何岸苇(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 49 |
| 3 | 蜜瓜和西瓜果汁的射频介电特性及其与糖度的关系显示文摘为了解果汁的介电特性与其主要内部品质——糖度之间的关系,该文利用末端开路的同轴探头和阻抗分析仪测量了10 MHz~1.8 GHz的频率范围内不同成熟度的3个品种密瓜汁和4个品种西瓜汁的介电特性,同时测量了反映果汁糖度的可溶性固形物含量和果肉的含水率,分析了介电特性和糖度间的关系。结果显示:密瓜和西瓜果汁的相对介电常数和介质损耗因数皆随频率的增大单调减小,品种间的差异对介电特性有影响;1.8 GHz下密瓜汁的损耗角正切与糖度有较好的线性关系,其决定系数为0.784,但西瓜汁的介电特性与糖度的相关性较差;密瓜和西瓜果汁的糖度与果肉的含水率有很好的线性相关性,其决定系数分别为0.973和0.906。该研究将为基于介电特性的果汁糖度检测仪的开发提供了研究基础。 | 郭文川 Smart O. Nelson Samir Trabelsi Stanley J. Kays | 2008 | 农业工程学报2008，24，5： | 38 |
| 4 | 含蛭石晶层间层矿物的可交换性阳离子及交换容量研究显示文摘对采自新疆尉犁蛭石矿、河南灵宝—陕西潼关蛭石矿的工业蛭石矿物样品进行了可交换性阳离子与交换容量研究 ,发现新疆尉犁蛭石矿金云母蛭石中可交换性阳离子主要为Na+ 和Ca2 + ,其次为Mg2 + 、K+ 、Ba2 + 和Sr2 + ;而河南灵宝—陕西潼关蛭石矿工业蛭石样品的可交换性阳离子主要为Ca2 + 和Mg2 + ,其次为Na+ 、K+ 等。金云母蛭石和绿泥石蛭石间层矿物的阳离子交换容量随间层结构中蛭石晶层的含量增加而增大 ,一般在 5 6 .92~ 98.95mmol/ 10 0g之间 ,仅为蛭石最大阳离子交换容量的一半。金云母蛭石样品阳离子交换容量大小与K2 O含量呈负相关关系 ,与 (Na2 O +CaO) | 彭同江 刘福生 John Huang Nelson Belzile 孙红娟 | 2003 | 岩石矿物学杂志2003，22，4： | 29 |
| 5 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 6 | 转型升级背景下小微企业专利融资模式创新研究显示文摘专利质押融资是小微企业与银行之间的协同创新行为。国内小微企业转型升级引发了新的融资需求,而目前小微企业实际融资不畅,使得专利融资成为小微企业的应急之需。在对小微企业专利质押融资现状及其障碍性因素进行分析的基础上,提出助推小微企业专利产业化、构建专利融资协同体系、持续加大对小微企业专利信贷的支持力度、搭建专利质押融资平台、继续实施中小企业知识产权战略推进工程等应对策略,以及实施供应链专利融资、大数据金融等创新模式。 | 李明星 Nelson Amowine 何娣 张慜 | 2013 | 科技进步与对策2013，30，18： | 23 |
| 7 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 8 | Current issues in endoscope reprocessing and infection control during gastrointestinal endoscopy显示文摘这篇文章的目的是在胃肠的内视镜检查法,在内诊镜 reprocessing 重要的因素和感染控制期间关于感染的传播考察证据,集中于的区域在这域里改进依从,和最近的开发和进展。 | Douglas B Nelson Lawrence F Muscarella | 2006 | World Journal of Gastroenterology2006，12，25： | 19 |
| 9 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 10 | A review of friction stir welding of steels: Tool, material flow, microstructure, and properties显示文摘Considerable progress has been achieved in friction stir welding(FSW) of steels in every aspect of tool fabrication, microstructure control and properties evaluation in the past two decades. With the development of reliable welding tools and precise control systems, FSW of steels has reached a new level of technical maturity. High-quality, long welds can be produced in many engineering steels. Compared to traditional fusion welding, FSW exhibits unique advantages producing joints with better properties. As a result of active control of the welding temperature and/or cooling rate, FSW has the capability of fabricating steel joints with excellent toughness and strength. For example, unfavorable phase transformations that usually occur during traditional welding can be avoided and favorable phase fractions in advanced steels can be maintained in the weld zone thus avoiding the typical property degradations associated with fusion welding. If phase transformations do occur during FSW of thick steels, optimization of microstructure and properties can be attained by controlling the heat input and post-weld cooling rate. | F.C. Liu Y. Hovanski M.P. Miles C.D. Sorensen T.W. Nelson | 2018 | Journal of Materials Science & Technology2018，34，1： | 16 |
| 11 | Fluidized-Bed Bioreactor Applications for Biological Wastewater Treatment: A Review of Research and Developments显示文摘污水处理是保护环境和人类健康的重要过程。目前,最经济有效的污水处理方法为生物处理法,如运行时间较长的活性污泥法。然而,随着人口的增长,对新型高效污水处理技术的需求越来越迫切,流态化技术虽然已展示出能够提高许多化学与生化处理过程的效率,但尚未在大型污水处理过程中得到广泛的应用。循环流化床生物反应器(CFBBR)污水处理技术的研究始于加拿大西安大略大学,在该技术中,载体颗粒表面会形成一层含细菌与其他微生物的生物膜,并在反应器中呈流化状态;流态化固有的良好混合和质量传递特性,使得该技术在生活污水和工业污水处理过程中均具优势。实验室阶段和中试阶段的研究均证实了CFBBR可去除污水中90%以上的碳源、80%以上的氮源,且污泥产量少于活性污泥法的1/3。由于该技术的高效性,CFBBR还可被用于传统方法难以处理的高有机碳污水处理,且具有占地面积小的优势。同时,CFBBR在动态负荷试验(进水量和进水浓度变化)中也展现了良好的抗冲击和恢复性能。总的来说,CFBBR是一种高效的污水处理方法,可在较短的水力停留时间和较小的反应器体积内处理更多的污水。此外,该反应器的紧凑设计将有助于在偏僻地区建造独立的污水处理系统。 | Michael J. Nelson George Nakhla Jesse Zhu | 2017 | Engineering2017，3，3： | 14 |
| 12 | 艺术、手工艺和非物质文化遗产:动态中操行的体系显示文摘在探索中国非物质文化遗产体系的过程中,了解西方学者对相关问题的观点、态度是非常重要的。Nelson Graburn是当下西方著名的人类学家,他不仅擅长诸如旅游人类学、博物馆、北美原住民文化等的研究,对无形文化遗产也有深度研究,并长期参与联合国教科文组织无形文化遗产各种会议和地方(日本、葡萄牙、北美)遗产保护实践。Nelson认为,遗产就是人们意识到需要去保护的那部分文化。不同国家有不同的历史、不同的环境和不同问题,因此努力探索自己国家更为合适的ICH(intangible cultural heritage)体系是全球普遍的过程。在今天的中国还应特别强调遗产语境。 | 彭兆荣 Nelson Graburn 李春霞 | 2012 | 贵州社会科学2012，，9： | 13 |
| 13 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 14 | Molecular genetics and targeted therapeutics in biliary tractcarcinoma显示文摘The primary malignancies of the biliary tract, cholangio-carcinoma and gallbladder cancer, often present at an advanced stage and are marginally sensitive to radiation and chemotherapy. Accumulating evidence indicates that molecularly targeted agents may provide new hope for improving treatment response in biliary tract carcinoma(BTC). In this article, we provide a critical review of the pathogenesis and genetic abnormalities of biliary tract neoplasms, in addition to discussing the current and emerging targeted therapeutics in BTC. Genetic studies of biliary tumors have identified the growth factors and receptors as well as their downstream signaling pathways that control the growth and survival of biliary epithelia. Target-specific monoclonal antibodies and small molecules inhibitors directed against the signaling pathways that drive BTC growth and invasion have been developed. Numerous clinical trials designed to test these agents as either monotherapy or in combination with conventional chemotherapy have been completed or are currently underway. Research focusing on understanding the molecular basis of biliary tumorigenesis will continue to identify for targeted therapy the key mutations that drive growth and invasion of biliary neoplasms. Additional strategies that have emerged for treating this malignant disease include targeting the epigenetic alterations of BTC and immunotherapy. By integrating targeted therapy with molecular profiles of biliary tumor, we hope to provide precision treatment for patients with malignant diseases of the biliary tract. | Eric I Marks Nelson S Yee | 2016 | World Journal of Gastroenterology2016，22，4： | 13 |
| 15 | Immunotherapeutic approaches in biliary tract carcinoma:Current status and emerging strategies显示文摘For biliary tract carcinoma(BTC),complete surgical resection of tumor is only feasible in a minority of patients,and the treatment options for patients with unresectable or metastatic disease are limited.Advances in cancer immunology have led to identification of tumor-infiltrating immune cells as indicators of prognosis and response to treatment in BTC.This has also facilitated development of immunotherapy that focuses on enhancing the immune system against biliary tumors.This includes peptide- and dendritic cell-based vaccines that stimulate in-vivo immune responses against tumorspecific antigens.Adoptive immunotherapy,which entails the ex-vivo expansion of tumor-infiltrating immune cells for subsequent reintroduction,and cytokinebased therapies have been developed in BTC.Clinical studies indicate that this type of therapy is generally well tolerated.Combination therapy with dendritic cell-based vaccines and adoptive immunotherapy has shown particularly good potential.Emerging strategies through discovery of novel antigen targets and by reversal of tumor-associated immunosuppression are expected to improve the efficacy of immunotherapy in BTC.Collaborative efforts by integration of targeted immunotherapeutics with molecular profiling of biliary tumor will hopefully make a positive impact on advancing towards the goal of developing precision treatment of patients with this highly lethal disease. | Eric I Marks Nelson S Yee | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 11 |
| 16 | Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine显示文摘OBJECTIVE:To evaluate the application of health assessment instruments in Chinese medicine. METHODS:According to a pre-defined search strategy,a comprehensive literature search for all articles published in China National Knowledge Infrastructure databases was conducted.The resulting articles that met the defined inclusion and exclusion criteria were used for analysis. RESULTS:A total of 97 instruments for health outcome assessment in Chinese medicine have been used in fundamental and theoretical research,and 14 of these were also used in 29 clinical trials that were randomized controlled trials,or descriptive or cross-sectional studies. In 2 152 Chinese medicine-based studies that used instruments in their methodology,more than 150 questionnaires were identified.Among the identified questionnaires,51 were used in more than 10 articles(0.5%).Most of these instruments were developed in Western countries and few studies(4%) used the instrument as the primary evidence for their conclusions. CONCLUSION:Usage of instruments for health outcome assessment in Chinese medicine is increasing rapidly;however,current limitations include selection rationale,result interpretation and standardization,which must be addressed accordingly. | Feng-bin Liu Zheng-kun Hou Yun-ying Yang Pei-WU Li Qian-wen Li Nelson Xie Jing-wei Li Xiang-jing Zeng | 2013 | Journal of Integrative Medicine2013，11，3： | 11 |
| 17 | 藏北多格错仁红层及孢粉组合特征显示文摘青藏高原北部羌塘地块广泛出露第三纪陆相红层 ,确定这些红层及其变形的时代对认识青藏高原的形成演化过程具有非常重要的意义。 1998~ 1999年 ,INDEPTH III项目地质课题组人员 2次深入西藏可可西里地区进行科学考察 ,新发现藏北多格错仁红层 ,并在其中发现较多种属的孢粉化石。该孢粉组合反映以温带旱生草原为主体的古植被面貌。通过对青藏高原北部及邻区主要新生代盆地孢粉组合与古环境演化的对比分析 ,结合多格错仁红层上覆弱变形玄武岩 2 5~ 3 2Ma的40 Ar- 3 9Ar高精度测年资料 ,推断多格错仁红层的形成时代为晚中新世 ,多格错仁红层挤压变形所致的约 5 0 %的地壳缩短量发生在中新世末—上新世初。 | 吴珍汉 江万 Doug Nelson Bill Kidd | 2002 | 现代地质2002，16，3： | 11 |
| 18 | A computer vision system for defect discrimination and grading in tomatoes using machine learning and image processing显示文摘With large-scale production and the need for high-quality tomatoes to meet consumer and market standards criteria,have led to the need for an inline,accurate,reliable grading system during the post-harvest process.This study introduced a tomato grading machine vision system based on RGB images.The proposed system performed calyx and stalk scar detection at an average accuracy of 0.9515 for both defected and healthy tomatoes by histogramthresholding based on themean g-r value of these regions of interest.Defected regionswere detected by an RBF-SVMclassifier using the LAB color-space pixel values.Themodel achieved an overall accuracy of 0.989 upon validation.Four grading categories recognitionmodelswere developed based on color and texture features.The RBF-SVMoutperformed all the explored modelswith the highest accuracy of 0.9709 for healthy and defected category.However,the grading accuracy decreased as the number of grading categories increased.A combination of color and texture features achieved the highest accuracy in all the grading categories in image features evaluation.This proposed system can be used as an inline tomato sorting tool to ensure that quality standards are adhered to and maintained. | David Ireri Eisa Belal Cedric Okinda Nelson Makange Changying Ji | 2019 | Artificial Intelligence in Agriculture2019，，2： | 10 |
| 19 | Extraction of Lithium from Salt Lake Brine with Triisobutyl Phosphate in Ionic Liquid and Kerosene显示文摘 | GAO Daolin YU Xiaoping GUO Yafei WANG Shiqiang LIU Mingming DENG Tianlong CHEN Yuwei BELZILE Nelson | 2015 | Chemical Research in Chinese Universities2015，31，4： | 10 |
| 20 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员