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您的检索式：作者名="Navneet Goyal"
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| 1 | Potential role of noninvasive biomarkers during liver fibrosis显示文摘Various types of liver disease exist,such as hepatitis and alcoholic liver disease.These liver diseases can result in scarring of liver tissue,cirrhosis,and finally liver failure.During liver fibrosis,there is an excess and disorganized accumulation of extracellular matrix(ECM)components which cause the loss of normal liver cell functions.For patients with chronic liver disease,fibrosis prediction is an essential part of the assessment and management.To diagnose liver fibrosis,several invasive and noninvasive markers have been proposed.However,the adoption of invasive markers remains limited due to their inherent characteristics and poor patient acceptance rate.In contrast,noninvasive markers can expedite the clinical decision through informed judgment about disease stage and prognosis.These noninvasive markers are classified into two types:Imaging techniques and serum biomarkers.However,the diagnostic values of biomarkers associated with liver fibrosis have also been analyzed.For example,the serum levels of ECM proteins can react to either matrix accumulation or degradation.During virus-host interactions,several regulatory steps take place to control gene expression,such as the change in cellular microRNA expression profiles.MicroRNAs are a class of non-coding RNAs(18-20 long nucleotides)that function by post-transcriptional regulation of gene expression.Although various noninvasive markers have been suggested in recent years,certain limitations have restricted their clinical applications.Understanding the potential of non-invasive biomarkers as a therapeutic option to treat liver fibrosis is still in progress. | Navneet Kaur Gitanjali Goyal Ravinder Garg Chaitanya Tapasvi Sonia Chawla Rajneet Kaur | 2021 | World Journal of Hepatology2021，13，12： | 3 |
| 2 | Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine显示文摘Aim:In this study,our goal was to study the inhibition of nicotine metabolism by P4502A6,as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers.Nicotine,a phytochemical,is an addictive stimulant,responsible for the tobacco-dependence in smokers.Many of the other phytochemicals in tobacco,including polycyclic aromatic hydrocarbons,N-nitrosamines,and aromatic amines,are potent systemic carcinogens.Tobacco smoking causes about one of every five deaths in the United States annually.Nicotine plasma concentration is maintained by the smokers’smoking behavior within a small range.Nicotine is metabolized by cytochrome P450s 2A6 and 2A13 to cotinine.This metabolism causes a decrease in nicotine plasma levels,which in turn leads to increased tobacco smoking,and increased exposure to the tobacco carcinogens.Methods:Using the phytochemical nicotine as a lead structure,and taking its interactions with the P4502A6 binding pocket into consideration,new pyridine derivatives were designed and synthesized as potential selective mechanism-based inhibitors for this enzyme.Results:The design and synthesis of two series of novel pyridine-based compounds,with varying substituents and substitution locations on the pyridine ring,as well as their inhibitory activities on cytochrome P4502A6 and their interactions with its active site are discussed here.Substitutions at position 3 of the pyridine ring with an imidazole or propargyl ether containing group showed the most optimal interactions with the P4502A6 active site.Conclusion:The pyridine compounds with an imidazole or propargyl ether containing substituent on position 3 were found to be promising lead compounds for further development.Hydrogen-bonding interactions were determined to be crucial for effective binding of these molecules within the P4502A6 active site. | Navneet Goyal Jayalakshmi Sridhar Camilla Do Melyssa Bratton Shahensha Shaik Quan Jiang Maryam Foroozesh | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
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