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| 1 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 2 | Sudden death in youngcompetitiveathletes:clinicopathologic correlationsin22cases显示文摘 | Corrado D Thiene G Nava A | 1990 | AmJMed1990，89，： | 1 |
| 3 | Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat显示文摘 | Luis M. Moquillaza María-Angeles Aller Maria-Paz Nava Luis Santamaría Patri Vergara Jaime Arias | 2009 | Acta Histochemica2009，，4： | 1 |
| 4 | Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy:myocardial and pericardial disease of the European society of cardiology and of the scientific council on cardiomyopathies of the international society and federation of cardiology显示文摘 | THIENE G NAVA A | 1994 | Br Heart J1994，71，3： | 1 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy in young versus adult patients:similarities and differences显示文摘 | Daliento L Turrini FP Nava A | 1995 | J Am Coll Cardiol1995，25，： | 1 |
| 6 | Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy显示文摘 | Pilichou K Nava A Basso C | 2006 | Circulation2006，113，9： | 1 |
| 7 | Antimicrobial susceptibility patterns of Haemophilus parasuis from pigs in the United Kingdom and Spain 显示文摘 | de la Fuente A J Tucker A W Navas J | 2007 | Vet Microbiol2007，120，12： | 1 |
| 8 | Liver function tests and glucose and lipid metabolism in growth-retarded fetuses显示文摘 | NAVA S BOCCONI L | 1999 | Obstet Gynecol1999，94，： | 1 |
| 9 | Patterns of soil organic carbon and nitrogen in relation to soll movement under different land uses in mountain fields( south central Pyrenees)显示文摘 | NAVAS A GASPAR L QUIJANO L | 2012 | Catena2012，94，： | 1 |
| 10 | Cutting edge:Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression显示文摘 | Gewirtz A T Navas T A Lyons S | 2001 | J Immunol2001，167，： | 1 |
| 11 | Microstructure formation of AI-Fe-Mn-Si aluminides by pressure-assisted reactive sintering of elemental powder mixtures 显示文摘 | FLORES A TOSCANO J A RODRIGUEZ S SALINAS A NAVA E | 2009 | Advanced Materials Research2009，68，： | 1 |
| 12 | Diagnosis of axrhythmogenic right ventricular dysplasia/cardiomyopathy: Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology 显示文摘 | McKenna WJ Thiene G Nava A | 1994 | Br Heart J1994，71，3： | 1 |
| 13 | Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy显示文摘 | Nava A Bauce B Basso C | 2000 | J Am Coll Cardiol2000，36，3： | 1 |
| 14 | An integrative study ofthe temperature dependence of whole animal and muscle performance during jumping and swimming in the frog Rana temporaria显示文摘 | Navas C A James R S Wakeling J M | 1999 | Joumal of Comparative Physiology B1999，169，： | 1 |
| 15 | Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy 显示文摘 | Rampazzo A Nava A Malacrida S | 2002 | Am J Hum Genet2002，71，5： | 1 |
| 16 | Iron distribution in different tissues in rats following exercise显示文摘 | NAVAS F J Cordova A | 2000 | Biol Trace Elem Res2000，73，3： | 1 |
| 17 | The evolution of thermal physiology in ectotherms显示文摘 | Angilletta M J Niewiarowski P H Navas C A | 2002 | Journal of Theoretical Biology2002，27，： | 1 |
| 18 | Sudden death inyoung competitive athletes : clinicopathologic correlations in 22 ca-ses显示文摘 | CORRADO D THIENE G NAVA A | 1990 | Am J Med1990，89，5： | 1 |
| 19 | Right ventricular cardiomyopathy and sudden death in young people 显示文摘 | Thiene G Nava A Corrado D | 1988 | N Engl J Med1988，318，： | 1 |
| 20 | Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy显示文摘 | Pilichou K Nava A Basso C | 2006 | Circulation2006，113，9： | 1 |
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