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| 1 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 2 | Determination of Partial Molar Volumes of EPA and DHA Ethyl Esters in Supercritical Carbon Dioxide显示文摘The use of supercritical-fluid chromatography for determining partial molar volumes of ethyl esters of cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and cis -4,7,10,13,16,19- docosa-hexaenoic acid (DHA) in supercritical carbon dioxide is presented and discussed. Partial molar volumes of EPA and DHA esters are obtained from the variation of the retention properties with the density of mobile phase at 313.15 K, 323.15 K, 333.15 K and in the pressure range from 9 MPa to 21 MPa. | Mei HUANG, Xian Da WANG, Ren Tian XIONG, Ping Dong WU, Qi Long REN* National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027 | 2002 | Chinese Chemical Letters2002，13，1： | 6 |
| 3 | Elevated pulse pres- sure is associated with age-related decline in language ability 显示文摘 | Nation DA Wierenga CE Delano-Wood L | 2010 | J Int Neuropsychol Soc2010，16，5： | 1 |
| 4 | Total Synthesis of Several 8, 8',-Biflavones显示文摘Four 8, 8'-biflavones were synthesized by the iodination of 2’-hydroxychalcones at 8position in I2-H2SO4-DMSO system as the key step followed by coupling under Ullmann reaction conditions. | Lian Yun ZHAO Shi Jun DA Yu Lin LI Wen CEN Ya Cheng XING(National Laboratory of Applied Organic Chemistry, LanZhou University, Lanzhou 730000 Department of Chemistry, Qingdao University, Qingdao 266071) | 1998 | Chinese Chemical Letters1998，9，4： | 1 |
| 5 | Interactive effects of vascular risk burden and advanced age on cerebral blood flow 显示文摘 | Bangen KJ Nation DA Clark LR | 2014 | Front Aging Neurosci2014，6，： | 1 |
| 6 | Elevated pulse pressure is associated with age-related decline in language ability显示文摘 | Nation DA Wierenga CE Delano-Wood L | 2010 | J Int Neuropsychol Soc2010，16，5： | 1 |
| 7 | Pulse pressure is associated with Alzheimer biomarkers in cognifively normal older adults 显示文摘 | Nation DA Edland SD Bondi MVV | 2013 | Neuralo~''2013，81，23： | 1 |
| 8 | Influence of vascular oxidative stress and inflammation on the development and progression of atherosclerosis显示文摘 | Nation DA Gonzales JA Mendez AJ | 2008 | Psychosom Med2008，70，3： | 1 |
| 9 | Photocatalytic C-H Bonds Activation:Ambient Carbonylation of Cyclohexane by Co(acac)_2 Under Ultraviolet Irradiation显示文摘A high turnover number was achieved in the photocatalytic carbonylation of C - H bonds of cyclohexane catalyzed by Co (acac)2 under ambient conditions (1 atm,25℃) to give mainly cyclohexanecarboxaldehyde. | Da Bin GAo Jing Mei YIN Ming GUO Yuan YU(Departemnt of Chemistry & Chemical Engineering, Dalian University, Dalian 116622)Yong An MA(National Marine Environmental Monitoring Center, Institute of Marine Environmental Protection, State Oceanic Administrat | 1997 | Chinese Chemical Letters1997，8，9： | 0 |
| 10 | Xylene-induced Effects on Brain Neurotransmitters, Behavior and Fos Protein in Rats显示文摘Male Sprague-Dawley rats administered xylene intrapetitoneally on alternate days at a dose of 125 or 250mg/kg for 30 days exhibited no marked changes in locomotor activity, learning and memory capacity. However in rats given xylene on alternate day at a dose of 500 mg/kg for 30 days, a significant decrease in locomotor activity, deficits in leaming ability and memory loss were detected. These xylene-induced behavioral ehanges were assoryiated with a decrease in fyendorphin and leuenkaphlin concentrations in the pons-medulla. On the contrary, xylene at a dose of 500mg/kg increased the β-endorphin level in caudate and c-fos expression in hippocampus. These data suggest that the xylene-induced behavioral alterations might be associated with the expression of Fos protein in the hippocampus. | WANG XIU-LUNG JIN XI-PENG FU HUA CHEN ZI-QING DA CUI-DI HUANG XIAN-FEN DING BAO-QING (Institute of Occupational Medicine, Chinese Academy of Preventive Medicine,29 Nan Wei Road, Beijing 100050, China Deprtment of Occupational Health, School of Public Health, Shanghai Medical University, Shanghai 200032, China National Key Laboratory of Neurobiolegy, Shanghai Medical University Institute of Occupational Diseases, Yumen Oil Administration, Gansu Province, China) | 1999 | Biomedical and Environmental Sciences1999，12，2： | 0 |
| 11 | 基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究显示文摘原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。 | Zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi Liu Yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai Hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu Zhu Xin Wang Rong Fu Liang Huang Shao-Yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-Xia Fu Xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu Xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group | 2023 | Science Bulletin2023，68，18： | 0 |
| 12 | Photoassisted Methoxycarbonylation of Straight-Chain Terminal Olefins under Ambient Conditions显示文摘Methoxycarbonylation was performed on 1 -heptene, 1-octene and 1 -dodecene withCo(acac)2 catalyst in the presence of UV light under ambient conditions. | Da Bin GAO Ming GUO Xiao Hui ZHANG (Department of Chemistry & Chemical Engineering, Dalian University, Dalian 116622)Jing Mei YIN (Open Laboratory of Carbon Resource Utilization, Dalian University of Technology, Dalian116012)Yong An MA (National Marin | 1998 | Chinese Chemical Letters1998，9，5： | 0 |
| 13 | An Encoder/Decoder Scheme of OCDMA Based on Waveguide显示文摘A new encoder/decoder scheme of OCDMA based on waveguide is proposed in this paper. The principle as well as the structure of waveguide encoder/decoder is given. It can be seen that all optical OCDMA encoder/decoder can be realized by the proposed scheme of the waveguide encoder/decoder. It can also make the OCDMA encoder/decoder integrated easily and the access controlled easily. The system based on this scheme can work under the entirely asynchronous condition. | GAO Ze hua,\ QIAN Zong jue,\ XU Da xiong Foundation item: This work is supported by the National Foundation Natural Science of China under project No.69990540(3). Biography:\ GAO Ze hua(1971-), male, from Shandong Province, Ph.D., Beijing Universit | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，1： | 0 |
| 14 | NEW OSCILLATING CHEMICAL REACTIONS WITH THE PARTICIPATION OF A COPPER(Ⅱ)TETRAAZAMACROCYCLIC COMPLEX显示文摘NEW OSCILLATING CHEMICAL REACTIONS WITH THE PARTICIPATION OF A COPPER(Ⅱ)TETRAAZAMACROCYCLIC COMPLEXNEWOSCILLATINGCHEMICALREAC... | Xiang Da ZHAO Zhi Qiang XU Liang ZHAO Ying Fang WANG Fu Xin XIE and Shi Sheng NI(Department of Chemistry, Anhui University, Hefei 230039)(National Key Lab. of Coord. Chem. in Nanjing Unly., Nanjing 210008) | 1994 | Chinese Chemical Letters1994，5，4： | 0 |
| 15 | A Novel Pentadecanuclear Neodymium Cluster: Synthesis and Structure of [Nd_(15)(μ_4-tyr)_(10)(μ_3-OH)_(20)(μ_2-OH)_4(OH)_(10)(μ_2-H_2O)-(H_2O)_(10)][Na(ClO_4)_2]·61H_2O显示文摘The title complex was synthesized by dissolving tyrosine (tyr) in an aqueous solution ofNd(ClO4)3 at NpH5, and its crystal stfucture was determined by X-ray diffraction methods. Thecomplex is a novel pentadecanuclear with the 15 Nd3+ ions connected by μ3-OH- ions. The tyrosineligands are all in their anionic form, and each coordinates to the neodymium ions via the nitrogenatom of the amino group and the two carboxyl oxygen atoms. The molecule a barrel structure. | Rui Yao WANG Zhe Ming WANG Song GAO Tian Zhu JIN Zhi Da CHEN Chun Hua YAN Guang Xian XU (State Key Laboratory of Rare Earth Material Chemistry and ApplicationsPeking UniverSity, Beijing 100871)Cun Heng HE (National Research Center for Analysis of Dr | 1998 | Chinese Chemical Letters1998，9，12： | 0 |
| 16 | Differential expression of a cDNA clone in human liverversus hepatic cancer-highly homologous to aryl-dialkyl-phosphatase显示文摘We applied the technique of mRNA differential display to normal liver tissue and hepatoma cell line Hep3B. One of the isolated cDNA clones was expressed in human normal liver tissue but not in the human hepatocarcinoma cell line. Northern Blot analysis confirmed that high level of mRNA was expressed in human normal liver tissue but the level was decreased in non-cancerous liver tissue from hepatoma patients. Low level or no expression was observed in human hepatoma tissue. One of these transcripts was about 1.8 kb in length. Southern Blot analysis showed that it was a single copy gene. We obtained a full length cDNA clone of 2,395 bp by screening human liver 5’-stretch plus cDNA library. Nucleotide sequence indicated that this clone was highly homologous to aryldialkyl-phosphatase and possessed two polymorphic sites. Aryl-dialkyl--phosphatase which has a prominent role in the metabolism of several toxic, synthetic compounds, may be potentially related to human hepatocarcinoma susceptibility. The biological significance of its differential expression in normal versus malignant tissue is discussed. | WANG KAN KAN DA FANG WAN XIAO KUN QIU PEI XIN LU JIAN REN GU(National La6oratory for Oncogenes and Related Genes Shanghai Cancer Institute, Shanghai 200032)(Qidong Cancer Institute, Jiangsu 226200) | 1997 | Cell Research1997，7，1： | 0 |
| 17 | Capillary Electrophoresis in the Presence of Fosfomycin显示文摘WT5”HZ]Fosfomycin, a sodium salt of cis (3 methyioxiranyl) phosphonic acid, was used as electrolyte in binary methanol water media for capillary electrophoresis. The variety of electroosmotic flow with pH *,methanol concentration and ionic strength was investigated. The migration behavior of nine hases was examined under various conditions, and the separation of thymine, cytosine, 5 flurouracil, 4,6 diamino pyrimidine, purine was accomplished. | XIE Min jie, FENG Yu qi , DA Shi lu College of Chemistry and Environmental Science, Wuhan University, Wuhan 430072, China Received date: 1999 09 29 Corresponding author Foundation item: Supported by the National Natural Science Foundation o | 2000 | Wuhan University Journal of Natural Sciences2000，5，2： | 0 |
| 18 | Synthetic Studies on Diarylheptanoids──Syntheses of 1,7-Bis(4-Hydroxyphenyl)-1,4,6-Heptatriene-3-One and Acetogenin G显示文摘The two new diarylheptanoids, 1,7-bis(4-hydroxyphenyl)-1,4,6 (l) and aecrogenin G (2) were Synthesized starting from 4-hydroxybenzaldehyde (3) and | Shi Jun DA Ying LI Chu Sheng HUANG Xiao Hong LI and Yu Lin LI(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, LanZhou University, Lanzhou 730000) | 1997 | Chinese Chemical Letters1997，8，4： | 0 |
| 19 | The Carbonylations of Cyclohexene with Carbon Dioxide显示文摘It is introduced that the carbonylations ofcyclohexene with CO2 can take place under ambient conditions by catalysis of Co(acac)2 in the presence of ultraviolet irradiation. | Da Bin GAO Jing Mei YIN Yong An MA(Open Laboratory of Carbon Resource Utilization,Dalian University of Technology Dalian 116012 Department of Chemistry & Chemical Engineering, Dalian University Dalian 116622 National Marine Environmental Monitoring Cent | 1999 | Chinese Chemical Letters1999，10，7： | 0 |
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