3篇
您的检索式：作者名="Nathan M.Springer"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic Patterns of Gene Expression Additivity and Regulatory Variation throughout Maize Development显示文摘Gene expression variation is a key component underlying phenotypic variation and heterosis. Transcriptome profiling was performed on 23 different tissues or developmental stages of two maize inbreds, B73 and Mo17, as well as their hybrid. The obtained large-scale datasets provided opportunities to monitor the developmental dynamics of differential expression, additivity for gene expression, and regulatory variation. The transcriptome can be divided into .30 000 genes that are expressed in at least one tissue of one in bred and an additional ~10 000 “silent” genes that are not expressed in any tissue of any genotype, 90% of which are non-syntenic relative to other grasses. Many (.74%) of the expressed genes exhibit differential expression in at least one tissue. However, the majority of genes with differential expression do not exhibit consistent differential expression in different tissues. These genes often exhibit tissue-specific differential expression with equivalent expression in other tissues, and in many cases they switch the directionality of differential expression in different tissues. This suggests widespread variation for tissue-specific regulation of gene expression between the two maize inbreds B73 and Mo17. Nearly 5000 genes are expressed in only one parent in at least one tissue (single parent expression) and 97% of these genes are expressed at mid-parent levels or higher in the hybrid, providing extensive opportunities for hybrid complementation in heterosis. In general, additive expression patterns are much more common than non-additive patterns, and this trend is more pronounced for genes with strong differential expression or single pare nt expressi on. There is relatively little evidence for non-additive expression patterns that are maintained in multiple tissues. The analysis of allele-specific expression allowed classification of cis. and trans-regulatory variation. Genes with c/s-regulatory variation often exhibit additive expression and tend to have more consistent regulatory variation throughout development. In contrast, genes with trans-reguiatory variation are enriched for non-additive patterns and often show tissue-specific differential expression. Taken together, this study provides a deeper understatiding of regulatory variation and the degree of additive gene expression throughout maize development. The dynamic nature of differential expression, additivity, and regulatory variation imply abundant variability for tissue-specific regulatory mechanisms and suggest that connections between transcriptome and phenome will require expression data from multiple tissues. | Peng Zhou Candice N.Hirsch Steven P.Briggs Nathan M.Springer | 2019 | Molecular Plant2019，12，3： | 2 |
| 2 | Genomic imprinting, methylation and molecular evolution of maize Enhancer of zeste (Mez) homologs显示文摘 | William J.Haun SylviaLaoueillé‐Duprat Mary J.O’Connell CharlesSpillane UeliGrossniklaus Allison R.Phillips Shawn M.Kaeppler Nathan M.Springer | 2006 | The Plant Journal2006，，2： | 1 |
| 3 | Opportunities to Use DNA Methylation to Distil Functional Elements in Large Crop Genomes显示文摘DNA methylation is a chromatin modification that is often associated with the exciti ng and sometimes unpredictable patter ns of inheritanee that can unfold with epigenetic phenomena. The stability and heritability of DNA methylati on patter ns perhaps allow us to utilize DNA methylation profiles to distil the suite of potentially functional elements in large crop genomes. Here, we discuss the potential and possible ways to use the absence of DNA methylation to identify potential regulatory regions within intergenic sequences and the presence of DNA methylation to identify pseudogenes. | Peter A.Crisp Jaclyn M.Noshay Sarah N.Anderson Nathan M.Springer | 2019 | Molecular Plant2019，12，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员