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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Recognition of staffNurse job perform- ance and achievements: staff andManager percep tions显示文摘 | Nones C S Donna B | 1999 | J Nuts Administr1999，29，1： | 1 |
| 4 | Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro:indirect action through astrocytes 显示文摘 | Jader Nones Tania Cristina Leite de Sampaio Spohr Flavia Carvalho Aleantara Gomes | 2012 | International Journal of Developmental Neuroscience2012，30，4： | 1 |
| 5 | Initiation and elongation steps of mRNA translation are involved in the increase in milk protein yield caused by growth hormone administration during lactation显示文摘 | Hayashi A A Nones K Roy N C | 2009 | Journal of dairy science2009，92，5： | 1 |
| 6 | Initia- tion and elongation steps of mRNA translation are in- volved in the increase in milk protein yield caused by growth hormone administration during lactation 显示文摘 | HAYASHI A A NONES K ROY N C | 2009 | Journal of Dairy Science2009，92，5： | 1 |
| 7 | Signaling modulation of bile salt induced necrosis in isolated rat hepatocytes显示文摘 | BORCK~NONE M PEREZ L M BASIGLIO C L | 2005 | Toxicol Sci2005，83，1： | 1 |
| 8 | Gene knockouts that affect male fertility: novel targets for contraception显示文摘 | Naz RK Engle A None R | 2009 | Front Biosci2009，14，： | 1 |
| 9 | BI 397, Dalbavancin, V - glycopeptide 显示文摘 | None | 2001 | Drug Fut2001，26，8： | 1 |
| 10 | Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma epigenetic deregulation of SLIT-ROBO, ITGA2 and reveal MET signaling显示文摘 | Nones K Waddell N Song S | 2014 | Int J Cancer2014，135，5： | 1 |
| 11 | Initiation and elongation steps of mRNA translation are involved in the increase in milk protein yield caused by growth hormone administration during lactation显示文摘 | Hayashi A A Nones K Roy N C | 2009 | Dairy Science2009，92，5： | 1 |
| 12 | Guidelines for evaluation of blood cell analysers including those used for differential leucocyte and reticulocyte counting and cell marker applications显示文摘 | None A | 1994 | Clin Lab Haematol1994，16，8： | 1 |
| 13 | Definitions for sepsis and organ failure and guidelines for use of innovative therapies in sepsis显示文摘 | None RC Balk RA Cerra FB | 1992 | Chest1992，101，6： | 1 |
| 14 | Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries显示文摘 | Markwalder TM Nones H | 1982 | J Neurosurg1982，57，： | 1 |
| 15 | Ventilation with lower tidal volumes as compared with tra- ditional tidal volumes for acute lung injury and the acute respir- atory distress syndrome显示文摘 | None | 2000 | N Engl J Med2000，342，18： | 1 |
| 16 | Comparisonof optical, need 1e probe andultrasonic techniques formeasurement articular cartilagethickness 显示文摘 | J li r v e 1 i n JS Rasanen T Kol nones P etc | 1995 | Journal ofBiomechanics1995，28，13： | 1 |
| 17 | The effects of dietary curcurain andrutin on colonic inflammation and gene expression in muhidrug resistance gene-deficient (mdrla-/-) mice, a model of inflammatory bowel diseases 显示文摘 | Nones K Dommels YE Martell S | 2009 | BrJNutr2009，101，2： | 1 |
| 18 | Genomic analyses identify molecular subtypes of pancreatic cancer 显示文摘 | Bailey P Chang DK Nones K | 2016 | Nature2016，531，7592： | 1 |
| 19 | Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens显示文摘 | Ye X Brown S R Nones K | 2007 | Genet Sel Evol2007，39，1： | 1 |
| 20 | R&D subsidiary isolation inknowledge-intensive industries:evidence from Austria显示文摘 | Williams C Nones B | 2009 | R&D Management2009，39，： | 1 |
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