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| 1 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 2 | Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection显示文摘无酶的氢过氧化物(H < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处,一个维的公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 nanowires,由小 nanoparticles 集合了,与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点,电子的面向的传播,和未受阻碍的小径,它资助公司 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果,获得的公司<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 氧化和高度敏感察觉。在生理的条件下面, H 的氧化电流<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”> 2 与 1.14 妈的敏感从 0.015~0.675 公里关于它的集中线性地变化?????????????? | Lingjun Kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu | 2015 | Nano Research2015，8，2： | 7 |
| 3 | Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid显示文摘The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid(OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion(HME) was applied to develop OA amorphous solid dispersions. The characterizations of the optimal formulation were performed by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy and in vitro dissolution test.The in vivo pharmacokinetic study was conducted in rats. As a result, OA solid dispersion based on PVP VA 64(OA-PVP) was successfully prepared. In the dissolution medium containing 0.3% SDS, OA-PVP dramatically increased the releasing rate of OA compared with the physical mixture(PM-PVP) and commercial tablet. Furthermore, OA-PVP exhibited higher AUC(P < 0.05) and Cmax(P < 0.05) than PM-PVP and commercial tablet. The superior dissolution property and bioavailability of OA-PVP mainly attributed to the amorphous state of OA in PVP VA64 and the well dispersion caused by thermal melting and shearing. Overall, hot melt extrusion was an efficient strategy to enhance the dissolution rate and oral bioavailability of OA. | Nannan Gao Mengran Guo Qiang Fu Zhonggui He | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，1： | 5 |
| 4 | On-chip sorting of orbital angular momentum beams using Bloch surface wave structures显示文摘Owing to their unique optical properties and new degrees of freedom,orbital angular momentum(OAM)beams have been applied in various fields.Detection of the topological charges(TCs)of OAM beams is the key step for their applications.However,on-chip sorting of OAM beams with large TCs still remains a challenge.In this paper,Bloch surface wave(BSW)structures with five semi-ring shaped nanoslits are modeled.A spatial separation of 135 nm on the chip is obtained between two neighboring OAM states.OAM beams with TCs up to 35 can be successfully sorted by the BSW structures,which is much larger than that using metallic structures(only seven).BSW structures exhibit better OAM sorting performances than metallic structures.We systematically show how the lower attenuation of BSW structures leads to far superior separation ability compared to surface plasmons propagating on metallic structures.In addition,sorting of two OAM beams with different TCs simultaneously can be achieved in this way.Our results reveal that BSW structures should be an excellent solution for OAM sorting with large TCs,which is beneficial for applications in integrated on-chip devices and optical communications. | NANNAN LI QI ZOU YIZHI LAN YAQI WANG JUN ZHANG MICHAEL SOMEKH CHANGJUN MIN FU FENG XIAOCONG YUAN | 2023 | Photonics Research2023，11，11： | 0 |
| 5 | Observing eddy dye patches induced by shear instabilities in the surf zone on a plane beach显示文摘The effects of surf zone eddy generated by alongshore currents on the deformation and transport of dye are still poorly understood,and related tracer release experiments are lacking.Therefore,a tracer release laboratory experiment was conducted under monochromatic,unidirectional incident waves with a large incident angle(30°)on a plane beach with a 1:100 slope in a large wave basin.A charge-coupled device suspended above the basin recorded the dye patch image.The evolution of eddy dye patch was observed and the transport and diffusion were analyzed based on the collected images.Subsequently,a linear instability numerical model was adopted to calculate the perturbation velocity field at the initial stage.The observation and image processing results show that surf zone eddy patches occurred and were separated from the original dye patches.Our numerical analysis results demonstrate that the structure of the perturbation velocity field is consistent with the experimental observations,and that the ejection of eddy patches shoreward or offshore may be ascribed to the double vortex. | Chunping Ren Nannan Fu Chong Yu Yuchuan Bai Kezhao Fang | 2024 | Acta Oceanologica Sinica2024，43，3： | 0 |
| 6 | Designable heteronanocrystals via interface redox reaction显示文摘The synergistic interaction of different components in heteronanocrystals induces interfacial phenomena and novel functionalities.Nonetheless,effective technologies to design and fabricate heteronanocrystals with materials on demand are still missing.Rich heterostructures in a copper patina are known to form at room temperature and under atmospheric pressure.The redox process of copper tarnish inspired the discovery of a simple strategy to achieve heteronanocrystals that contained elements from group 3-11 and group 14-16.The interface redox-induced method is self-regulating at ambient conditions and applicable for metal,semiconductor,and dielectric materials.The enhanced interface bonding endows the heteronanocrystals with outstanding stability and catalytic performance,while the modular approach enables the design and fabrication of heteronanocrystals with intended materials to meet different purposes. | Zhihua Li Yang Li Nannan Luo Yuanyuan Qie Dingyi Yang Guowei Cao Yuxiang Liu Ying Fu Na Li Wen Hu Min Zhang Rusen Yang Bo Tang | 2023 | Nano Research2023，16，4： | 0 |
| 7 | Characterization of Polysaccharides Extracted from a Cultivated Brown Alga Costaria costata During the Harvest Period显示文摘In this study,variations in composition and properties of polysaccharides isolated from brown algae Costaria costata were analyzed.The algae were collected from May to July of the harvest period.The carbohydrates alginate and fucoidan were extracted with selected solvents.1 H Nuclear magnetic resonance and rheology were used to investigate the monomer composition and rheological characteristics of alginate.Gas chromatography and Fourier transform-infrared spectroscopy were employed to investigate the compositional properties of purified fucoidan.The results indicated that the composition and properties of alginate and fucoidan varied during the life of this alga.The alginate from the alga harvested in May and June had a higher molecular weight,viscosity,and proportion of mannuronic acid,whereas that harvested in July had a lower molecular weight and viscosity but a higher proportion of guluronic acid.The alginate from C.costata had a higher molecular weight and a different mannuronic acid:guluronic acid ratios compared with other algae;thus,it could be used in the chemical,food,cosmetics,and pharmaceutical industries.Fucoidan content reached the maximum in June.Substantial changes in the molecular weight distribution,monosaccharide composition,and sulfate content occurred simultaneously.The fraction of fucose in the polysaccharides decreased significantly from June to July,whereas that of mannose increased.This alga can be harvested during different growth periods to obtain fucoidans and alginates with different compositions and,therefore,with different biological properties. | LIU Nannan WU Xin FU Xiaoting DUAN Delin XU Jiachao GAO Xin | 2018 | Journal of Ocean University of China2018，17，5： | 0 |
| 8 | Antioxidant induced bulk passivation for efficient and stable hole transport layer-free carbon electrode perovskite solar cells显示文摘Defect passivation is one of the important strategies to improve the efficiency and stability of perovskite solar cells.In this work,2,6-di-tert-butyl-4-methylphenol(BHT)as antioxidant was introduced into the perovskite precursor solution to improve the quality of the prepared perovskite films,so that these films performed a larger and uniform grain size.Moreover,the-OH functional group in BHT interacts with I-,thus reducing the density of defect states and inhibiting the non-radiative recombination.The presence of hydrophobic groups in BHT protects the film from moisture erosion and improves the long-term stability of PSCs devices.The maximum photoelectric conversion efficiency of the constructed ITO/SnO_(2)/BHTMAPbI_(3)/Carbon device is 16.88%,and the unpackaged cell maintains the initial efficiency of 99.3%after698 h of storage under the environmental condition of 30%humidity.This work provides an efficient approach to improve the performance of printable hole transport layer-free carbon electrode perovskite solar cells. | Yetai Cheng Qingbo Wei Nannan Wang Zhangwen Ye Yanbin Zhao Qiongyao Wang Depeng Chu Lingxing Zan Feng Fu Yucheng Liu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
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