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| 1 | Hepatoprotective effect of silymarin显示文摘The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from the species Silybum marianum,which is commonly known as Milk thistle.This plant contains at least seven flavoligands and the flavonoid taxifolin.The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon tetrachloride.The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation.Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. | Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y González-Rubio Juan A Gayosso-de-Lucio José A Morales-González | 2014 | World Journal of Hepatology2014，6，3： | 12 |
| 2 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | DNA microarray analysis of the expression of the genes encoding the major enzymes in ethanolproduction during glucose and xylose cofermentation by metabolically engineered Saccharomyces yeast显示文摘 | Miroslav S Howard J E Nancy W Y | 2003 | Science2003，，33： | 1 |
| 4 | The role of culture in the perception of service recovery显示文摘 | Nancy Y Wong | 2004 | Journal of Business Research2004，，57： | 1 |
| 5 | Activity of macrocyclic jatrop halle diterpenes from euphorbia kansui in a trk a fibroblast survial assay 显示文摘 | Oin P Fanny C F Nancy Y | 2004 | J Nat Prod2004，67，： | 1 |
| 6 | Enhanced cofermentation of glucose and xylose by recombinantSaccharomyces yeast strains in batch and continuous operating modes显示文摘 | t SUSAN T TOON GEORGE P PHILIPPIDIS NANCY W Y HO | 1997 | Applied Bio- chemistry and Biotechnology1997，6365，1： | 1 |
| 7 | Genetieally Engineered Saccharomyces Yeast Capable of Effective Cofermentation of Glucose and Xylose显示文摘 | Nancy W Y Chen Z D Adam | 1998 | Appl Environ Mierobiol1998，64，5： | 1 |
| 8 | A comparison of soil organic carbon stocks between residential turf grass and native soil 显示文摘 | Richard V P Ian D Y Nancy E G | 2009 | Urban Ecosystem2009，12，： | 1 |
| 9 | A novel mutation within the central Listeria monocytogenes regulator PrfA that results in constitutive expression of virulence gene products显示文摘 | Kendy K Y W Nancy E F | 2004 | J Bacteriol2004，186，： | 1 |
| 10 | Psychometric properties of the IPAQ:A validation study in a sample of northern Franco-Ontarians显示文摘 | GAUTHIER A P LARIVIERE M NANCY Y | 2009 | J Phy Act Health2009，6，： | 1 |
| 11 | Developments in the scientific under- standing of osteoporosis显示文摘 | Nancy E Lane N Wei Y | 2009 | Arthritis Res Ther2009，11，： | 1 |
| 12 | Sedation in the intensive care unit显示文摘 | Christopher Y Nancy K Andrew H | 2000 | Crit Care Med2000，28，： | 1 |
| 13 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 14 | Single-dose pharmacokinetic study of modafinil tablet: influence of age and gender in normal subjects 显示文摘 | NANCY WONG Y PETER S WATSON B | 1999 | Clin Pharmacol1999，39，： | 1 |
| 15 | Caspases: enemies within显示文摘 | Nancy A Thornberry Lazebnik Y | 1998 | Science1998，281，5381： | 1 |
| 16 | Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation显示文摘 | Wang H Y Li W W Nancy J | | 0，，34： | 1 |
| 17 | Activity of Macrocyclic Jatmphane Diterpenes from Euphorbia kansui in a TrkA Fibroblast Survival Assay显示文摘 | Qin P Fanny CF Nancy Y | 2004 | Journal of Natural Products2004，67，9： | 1 |
| 18 | Efficacy of reco mbinant methionyl human leptin therapy for the extreme insulin resistance of the rabson-mendenhallsy ndrome显示文摘 | Elaine C Janice R Y Nancy S | 2004 | J Clin Endocrinol Metab2004，89，4： | 1 |
| 19 | Hierarchically structured sulfur/carbon nanocomposite material for high-energy lithium battery显示文摘 | Liang Chengdu Dudney Nancy J Howe Jane Y | 2009 | Chemistry of Materials2009，21，19： | 1 |
| 20 | DNA microarray analysis of the expression of the genes encoding the major enzymes in ethanol production during glucose and xylose co-fermentation by metabolically engineered Saccharomyces yeast显示文摘 | Sedlak Miroslav Edenberg Howard J Ho Nancy W Y | 2003 | Enzyme and Microbial Technology2003，33，1： | 1 |
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