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| 1 | Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease显示文摘Despite improvement in outcomes, loss of response(LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical response, using a standard approach. Immunomonitoring involves the measurement of anti-TNFα trough and antibody levels. It takes into account the underlying pharmacokinetics of anti-TNFα therapies. Expanding on this a treat to target approach may be used, where doses are intensified, or tailored to the individual based on the measurement of anti-TNFα trough and antibody levels. This review looks at the history, evolution, and clinical impact that immunomonitoring is having in the treatment of inflammatory bowel disease. It will focus on the role of immunomonitoring in helping to achieve long lasting deep remission and mucosal healing. It will explore the different options in terms of best measuring trough and antibody levels, explore possible advantages of immunomonitoring, and discuss its role in best optimising response, at induction, during the maintenance phase of treatment, as well as a role in withdrawing or switching therapy. | Donal Tighe Deirdre Mc Namara | 2017 | World Journal of Gastroenterology2017，23，3： | 6 |
| 2 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 3 | Agricultural water management and poverty linkages显示文摘 | Namara R E Hanjra M A Castillo G E | 2010 | Agricultural Water Management2010，97，4： | 1 |
| 4 | Shareholder Returns and the Exploration-Exploitation Dilemma:R&d Announcements by Biotechnology Firms显示文摘 | Mc Namara P C Baden-Fuller | 2007 | Research Policy2007，36，4： | 1 |
| 5 | The present status of the marketing concept显示文摘 | Namara I | 1972 | Journal of Marketing1972，36，： | 1 |
| 6 | Exploratory drug safety:discovery strategy to reduce attrition in development显示文摘 | Bass AS Cartwright ME Mahon C Morrison R Snyder R Mc Namara P | 2009 | J Pharmacol Toxicol Methods2009，60，1： | 1 |
| 7 | Components of Class Ⅱ malocclusion in children 8-10 years of age 显示文摘 | Mc Namara JA | 1981 | Angle Orthod1981，51，3： | 1 |
| 8 | Paracentesis-an effective method of symptom control in the palliative care setting?显示文摘 | Namara P | 2000 | Palliat Med2000，14，1： | 1 |
| 9 | Water-based exercise in COPD with physical comorbidities:a randomised controlled trial显示文摘 | Mc Namara RJ Mc Keough ZJ Mc Kenzie DK | 2013 | Eur Respir J2013，41，6： | 1 |
| 10 | Dietary and biological factors influencing lactose intolerance显示文摘 | Brown-Esters O Mc Namara P Savaiano D | 2012 | Int Dairy J2012，22，： | 1 |
| 11 | A proposed autosomal dominant method of inheritance of the Wolff-Parkinson-White syndrome and supraventricular tachycardia显示文摘 | Gillette PC Freed D Namara DG | 1978 | J Pediatrics1978，93，： | 1 |
| 12 | Utility of the peak expiratory flow rate the differentiation of acute dyspnea, cardie vs pulmonary origin显示文摘 | MC NAMARA R CIONNI D J | 1992 | Chest1992，101，： | 1 |
| 13 | Dynamics of textile motion in a front-loading domestic washing machine 显示文摘 | NAMARA C Mac GABRIELE A AMADOR C | 2012 | Chemical Engineering Science2012，，3： | 1 |
| 14 | Aluminium toxicokinetics:an updated minireview显示文摘 | Yokel R A Mc Namara P J | 2001 | Pharmacology and Toxicology2001，88，4： | 1 |
| 15 | Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro显示文摘 | Brennan O O'Brien FJ Mc Namara LM | 2012 | Horm Metab Res2012，44，： | 1 |
| 16 | Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn 显示文摘 | Mc Namara PJ Laique F Muang-In S | 2006 | J Crit Care2006，21，2： | 1 |
| 17 | Can we decrease postdatism in women with an unfavorable cervix and a negative fetal fibronectin test result at term by serial membrane sweeping显示文摘 | Magann EF Mc Namara MF Whitworth NS | 1998 | Am J Obstet Gynecol1998，179，4： | 1 |
| 18 | Components of class Ⅱ malocclusion in children 8 -10 year of age显示文摘 | Mc Namara JA | 1981 | Angle Orthod1981，51，2： | 1 |
| 19 | Water-based exercise in COPD with physical co-morbidities:a randomized controlled trial显示文摘 | Mc Namara RJ Mc Keough ZJ Mc Kenzie DK | 2013 | Eur Respir J2013，41，6： | 1 |
| 20 | A- gricultural water management and poverty linkages 显示文摘 | NAMARA R E HANJRA M A CASTILLO G E | 2010 | Agri- cultural Water Management2010，97，4： | 1 |
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