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| 1 | Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis显示文摘A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis(CRLM),which involved the right hepatic vein(RHV)and the inferior vena cava(IVC),was referred to our hospital.The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC.After she had undergone laparoscopic sigmoidectomy for the original tumor,she consequently had 3 courses of modified 5-fluorouracil,leucovorin,and oxaliplatin(m FOLFOX6)plus cetuximab.Computed tomography revealed a partial response,and the confluence of the RHV and IVC got free from cancer invasion.After 3 additional courses of m FOLFOX6 plus cetuximab,preoperative percutaneous transhepatic portal vein embolization(PTPE)was performed to secure the future remnant liver volume.Finally,a right hemihepatectomy was performed.The postoperative course was uneventful.The patient was discharged from the hospital on postoperative day 13.She had neither local recurrence nor distant metastasis 18 mo after the last surgical intervention.This multidisciplinary strategy,consisting of conversion chemotherapy using FOLFOX plus cetuximab and PTPE,could contribute in facilitating curative hepatic resection for initially unresectable CRLM. | Kenta Baba Akihiko Oshita Mohei Kohyama Satoshi Inoue Yuta Kuroo Takuro Yamaguchi Hiroyuki Nakamura Yoichi Sugiyama Tatsuya Tazaki Masaru Sasaki Yuji Imamura Yutaka Daimaru Hideki Ohdan Atsushi Nakamitsu | 2015 | World Journal of Gastroenterology2015，21，6： | 10 |
| 2 | Current treatment strategies and future perspectives for gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are mesenchymal tumors that originate from the gastrointestinal tract,mostly from the stomach.GISTs are derived from the myenteric interstitial cells of Cajal and are caused by several mutations in the c-kit and platelet-derived growth factor receptor genes.Clinically,GISTs are detected by endoscopic and imaging findings and are diagnosed by immunostaining.Surgery is the first line of treatment,and if the tumor is relatively small,minimally invasive surgery such as laparoscopy is performed.In recent years,neoadjuvant therapy has been administered to patients with GISTs that are suspected of having a large size or infiltration to other organs.Postoperative adjuvant imatinib is the standard therapy for high-risk GISTs.It is important to assess the risk of recurrence after GIST resection.However,the effect of tyrosine kinase inhibitor use will vary by the mutation of c-kit genes and the site of mutation.Furthermore,information regarding gene mutation is indispensable when considering the treatment policy for recurrent GISTs.This article reviews the clinicopathological characteristics of GISTs along with the minimally invasive and multidisciplinary treatment options available for these tumors.The future perspectives for diagnostic and treatment approaches for these tumors have also been discussed. | Yoichi Sugiyama Masaru Sasaki Mohei Kouyama Tatsuya Tazaki Shinya Takahashi Atsushi Nakamitsu | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，1： | 5 |
| 3 | Kupffer cell function in ischemic and nonischemic livers after hepatic partial ischemia/reperfusion显示文摘 | Nakamitsu A Hiyama E Imamura Y | 2001 | Surg Today2001，31，： | 1 |
| 4 | Kupffer cell function in ischemia and nonischemic livers after hepatic partial ischemia/reperfusion显示文摘 | Nakamitsu A Hiyama E Imamura Y | 2001 | Surg Today2001，31，2： | 1 |
| 5 | On solutions of the initial value problem for the nonlinear Schrodinger equations显示文摘 | Nakamitsu K Tsutsumi M | 1987 | J Funct Anal1987，71，2： | 1 |
| 6 | Nonlinear Schrodinger equation in weighted Sobolev spaces显示文摘 | Nakamitsu K Tsutsumi M | 1988 | Funfcialaj Ekvacioj1988，31，3： | 1 |
| 7 | Thalidomide Controls Adipose Tissue Inflammation Associated with High-Fat Diet-Induced Obesity in Mice 显示文摘 | Nakamitsu P Z Compri C M Fraia P L | 2014 | Endocr Metah Immune Disord Drug Targets2014，，： | 1 |
| 8 | A case report of primary duodenal adenocarcinoma responding to chemotherapy with S-1 and irinotecan显示文摘 | Hadano N Imamura Y Nakamitsu A | | 0，，04： | 1 |
| 9 | Kupffer Cell Function in Ischemic and Nonischemic Livers After Hepatic Partial Ischemia/Reperfusion显示文摘 | Atsushi Nakamitsu Eiso Hiyama Yuji Imamura Yuichiro Matsuura Takashi Yokoyama | 2001 | Surgery Today2001，，2： | 1 |
| 10 | Kuppfer cell function inisehemic and nonischemic livers after hepatic partial isehemia/ reperfusion 显示文摘 | Nakamitsu A Hiyama E Imamura Y | 2001 | Surg Today2001，31，1： | 1 |
| 11 | Sequence vari ation of bovine prion protein gene in Japanese cattle (Holstein and Japanese Black) 显示文摘 | Nakamitsu S Miyazawa T Horiuchi M | 2006 | J Vet Med Sci2006，68，1： | 1 |
| 12 | Kupffer cell function in ischemic and nonischemic livers after hepatic partial ischemia/ repro'fusion 显示文摘 | Nakamitsu A Hiyarna E Imarnura Y | 2001 | Surg Today2001，31，： | 1 |
| 13 | On solutions of the initial value problem for the nonlinear Schrodinger equations显示文摘 | Hayashi N Nakamitsu K Tsutsumi M | 1987 | Journal of Functional Analysis1987，71，2： | 1 |
| 14 | Solitary peritoneal metastasis of gastrointestinal stromal tumor: A case report显示文摘BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the stomach.Recurrence of GISTs mostly occurs in the liver or peritoneum,and in most cases,multiple metastases occur.As a solitary peritoneal metastasis is rare,an appropriate treatment strategy has not been established.Here,we report a case of solitary peritoneal metastasis after complete resection of gastric GIST.CASE SUMMARY A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET method.As the recurrence risk was intermediate,adjuvant imatinib therapy was not administered.Two years after surgery,routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right kidney.Other imaging tests did not reveal any abnormalities.Laparoscopic observation showed that the tumor was located at the retroperitoneum,and intraperitoneal dissemination was not found.Therefore,we performed laparoscopic tumor resection.Immunohistochemically,the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling index.We administered adjuvant imatinib therapy.There was no evidence of recurrence 3 years after the operation.CONCLUSION This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection. | Yoichi Sugiyama Kensuke Shimbara Masaru Sasaki Mohei Kouyama Tatsuya Tazaki Shinya Takahashi Atsushi Nakamitsu | 2020 | World Journal of Gastroenterology2020，26，36： | 0 |
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