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| 1 | Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function显示文摘Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical problem.Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN.There is no specific pharmacological intervention for CN.Metformin is an anti-diabetic drug administered for decades.On the other hand,novel pharmacological properties have emerged for this drug.The effect of metformin on oxidative stress parameters has been well-recognized in different experimental models.It has also been found that metformin positively affected mitochondrial function.The current study aimed to evaluate the effects of metformin in an animal model of CN.Methods:Rats underwent bile duct ligation(BDL)and were treated with metformin(250 and 500 mg/kg)for 14 consecutive days.Two weeks after the BDL operations,urine,serum,and kidney samples were collected and analyzed.Results:Markers of oxidative stress,including reactive oxygen species(ROS)formation,lipid peroxida-tion,protein carbonylation,depleted antioxidant capacity,and decreased glutathione(GSH)levels were detected in BDL animals.Moreover,mitochondrial indices,including adenosine triphosphate(ATP)level,dehydrogenase activity,mitochondrial membrane potential,and mitochondrial permeability,were impaired in the kidney of cholestatic rats.Renal histopathological alterations in cholestatic animals included tubular degeneration and interstitial inflammation,cast formation,and fibrosis.It was found that metformin significantly alleviated oxidative stress and improved mitochondrial indices in the kidney of cholestatic rats.Tissue histopathological alterations were also mitigated in metformin-treated groups.Conclusions:Metformin could be a candidate for managing CN.The nephroprotective role of metformin is primarily associated with its effects on oxidative stress parameters and mitochondrial function. | Mohammad Mehdi Ommati Hamidreza Mohammadi Khadijeh Mousavi Negar Azarpira Omid Farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad Reza Heidari | 2021 | Liver Research2021，5，3： | 3 |
| 2 | Internal fixation of symphyseal disruption resulting from childbirth显示文摘 | NAJIBI S TANNAST M KLENCK R E | 2010 | j Orthop Trauma2010，2412，： | 1 |
| 3 | Enhanced role of potassium channels in relaxations to acetylcholine in hypercholesterolemic rabbit carotid artery显示文摘 | Najibi S Cowan CL Palacino JJ | 1994 | Am J Physiol1994，266，52： | 1 |
| 4 | Two to twenty-year survivorship of the hip in 810 patients with operatively treated acetabular fractures显示文摘 | Tannast M Najibi S Matta JM | 2012 | J Bnne Joint Surg Am2012，94，17： | 1 |
| 5 | Calcium sulphate scale formation during subcooled flow boiling 显示文摘 | Najibi S H Mtiller-Steinhagen H Jamialahmadi M | 1997 | Chemical Engineering Science1997，52，8： | 1 |
| 6 | Economic e- valuation of natural gas hydrate as an alternative for natu- ral gas transportation 显示文摘 | Javanmardi J Nasrifar K H Najibi S H | 2005 | Appl Therm Eng2005，25，1112： | 1 |
| 7 | Conservatism and new technology:the impact on abdominal aortic aneurysm repair显示文摘 | Bush RL Najibi S Lin PH | 2002 | Am Surg2002，68，1： | 1 |
| 8 | Enhanced role of K^+ channels in relaxations of hypercholesterolemic rabbit carotid artery to NO 显示文摘 | Najibi S Cohen RA | 1995 | Am J Physiol1995，269，3： | 1 |
| 9 | Nitric oxide directly activates calcium-depent potassium channels in vascular smooth muscle 显示文摘 | Bolotina M Najibi S Palacino J J | 1994 | Nature1994，368，： | 1 |
| 10 | Internal fixation of sym- pbyseal disruption resulting from childbirth 显示文摘 | Najibi S Tannast M Klenck RE | 2010 | J Orthop Trauma2010，24，12： | 1 |
| 11 | Covered stent exclusion of dialysis access pseudoaneurysms显示文摘 | Najibi S Bush RL Terramani TT | 2002 | J Surg Res2002，106，： | 1 |
| 12 | Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle显示文摘 | Bolotina VM Najibi S Palacino JJ | 1994 | Nature1994，368，6774： | 1 |
| 13 | Boiling and Nonboililng Heat Transfer to Electrolyte Solutions 显示文摘 | S H Najibi H Muller-steinhagen M Jamialahmadi | 1996 | heat transfer engineering1996，17，4： | 1 |
| 14 | Nitric oxide directly acti- vates calcium-dependent potassium channels in vascular smooth mus- cle显示文摘 | Bolotina VM Najibi S Palacino JJ | 1994 | Nature1994，368，6474： | 1 |
| 15 | Calcium sulphate scale formation during subcooled flow boiling显示文摘 | S.H. Najibi H. Müller-Steinhagen M. Jamialahmadi | 1997 | Chemical Engineering Science1997，，8： | 1 |
| 16 | Methane/natural gas stora- ge and delivered capacity for activated carbons in dry and wet conditions显示文摘 | Najibi I-I Chapoy A Tohidi B | 2008 | Fuel2008，，87： | 1 |
| 17 | Enzyme Polymorphism in War- farin Dose Management After Pediatric Cardiac Surgery 显示文摘 | Tabib A Najibi B Dalili M | 2015 | Res Cardiovasc Med2015，4，27： | 1 |
| 18 | Endoluminal versus open treatment of descending tho-racic aortic aneurysms显示文摘 | Najibi S Terramani TT Weiss VJ | 2002 | J Vasc Surg2002，36，4： | 1 |
| 19 | Sensing snow height and surface temperature variations in Greenland from GPS reflected signals显示文摘 | JIN S NAJIBI N | 2014 | Advances in Space Research2014，，： | 1 |
| 20 | Boiling and nonboiling heat transfer to electrolyte solutions 显示文摘 | Najibi S H Muller-steinhagen H Jamialahmadi M | 1996 | Heat Transfer Engineering1996，17，4： | 1 |
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