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| 1 | Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes显示文摘Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract.These dynamic communities,the environment and their metabolites constitute the microbiota.Growing data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer development.However,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still absent.The gut microbiota can exert direct or indirect effects in different phases of colorectal cancer genesis.For example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce genotoxins.However,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium nucleatum.Microbiota has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic leak.Consequently,unbalanced presence of some species,together with altered immune response may also have a prognostic role.Microbiota has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side effects.In other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine. | Ilenia Bartolini Matteo Risaliti Maria Novella Ringressi Filippo Melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei | 2020 | World Journal of Gastroenterology2020，26，20： | 6 |
| 2 | Presacral venous bleeding during mobilization in rectal cancer显示文摘AIM To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal cancer.METHODS A review of the databases MEDLINE? and Embase? was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were defined.RESULTS This is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious complication.CONCLUSION A series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications. | Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 3 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 4 | Gut microbiota and immune system in liver cancer:Promising therapeutic implication from development to treatment显示文摘Liver cancer is a leading cause of death worldwide,and hepatocellular carcinoma(HCC)is the most frequent primary liver tumour,followed by cholangiocarcinoma.Notably,secondary tumours represent up to 90% of liver tumours.Chronic liver disease is a recognised risk factor for liver cancer development.Up to 90% of the patients with HCC and about 20% of those with cholangiocarcinoma have an underlying liver alteration.The gut microbiota-liver axis represents the bidirectional relationship between gut microbiota,its metabolites and the liver through the portal flow.The interplay between the immune system and gut microbiota is also well-known.Although primarily resulting from experiments in animal models and on HCC,growing evidence suggests a causal role for the gut microbiota in the development and progression of chronic liver pathologies and liver tumours.Despite the curative intent of“traditional”treatments,tumour recurrence remains high.Therefore,microbiota modulation is an appealing therapeutic target for liver cancer prevention and treatment.Furthermore,microbiota could represent a non-invasive biomarker for early liver cancer diagnosis.This review summarises the potential role of the microbiota and immune system in primary and secondary liver cancer development,focusing on the potential therapeutic implications. | Ilenia Bartolini Matteo Risaliti Rosaria Tucci Paolo Muiesan Maria Novella Ringressi Antonio Taddei Amedeo Amedei | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 3 |
| 5 | Temperament,character,and attachment patterns in borderline personality disorder显示文摘 | Fossati A Donati D Donini M Novella L Bagnato M Maffei C | 2001 | J Personal Disord2001，15，： | 1 |
| 6 | Adrenal incidentalomas: Surgical treatment in 28 patients and update of the literature显示文摘 | Porcaro AB Novella G Ficarra V | 2002 | Int Urol Nephrol2002，32，： | 1 |
| 7 | Family caregivers and hereditary muscular disorders: Association between burden, quality of life and mental health 显示文摘 | Boyer F Novella JL Coulon JM | 2006 | Ann Readapt Med Phys2006，49，1： | 1 |
| 8 | Incidental detection beyond pathologiealfactors as prognostic predictor of renal cell carcinoma 显示文摘 | FICARRA V PRAYER-GALETTI T NOVELLA G | 2003 | Eur Urol2003，43，： | 1 |
| 9 | Nadolol plus isosorbide monomitrate compared with sclerotherapy for the prevention of variccal vebleeding显示文摘 | Villanlleva C Balanzo J Novella M | 1996 | N Engl J Med1996，334，： | 1 |
| 10 | Fluorescent polymerase chain reaction and capillary electrophoresis for IgH rearrangement and minimal residual disease evaluation in multiple myeloma显示文摘 | Novella E Giaretta I Elice F | 2002 | Haematologica2002，87，： | 1 |
| 11 | Amoxicillin-clavulanic acid versus cefotaxime in the therapy of bacterial infections in cirrhotic patients显示文摘 | Ricart E Soriano G Novella MT | 2000 | J Hepatol2000，32，4： | 1 |
| 12 | Antigenic specificity of porcine T cell response against foot-and-mouth disease virus structural pro- teins: identification of T helper epitopes in VPI 显示文摘 | Rodriguez A Saiz J C Novella I S | 1994 | Virology1994，205，1： | 1 |
| 13 | The potential impact of prostate volume in the planning of optimal number of cores in the systematic transperineal prostate biopsy 显示文摘 | Ficarra V Novella G Novara G | 2005 | Eur Urol2005，48，6： | 1 |
| 14 | MR imaging evaluation of endometrial eareinoma 显示文摘 | Novellas S Fournol M Caramella T | 2008 | J Radiol2008，89，： | 1 |
| 15 | ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine 显示文摘 | Ceppi P Volante M Novella S | 2006 | Ann Oncol2006，17，12： | 1 |
| 16 | Psycho- social well- being and general health status after surgical treatment for localized renal cell carcinoma显示文摘 | Ficarra V Novella G Sarti A | 2003 | Int Urel Nephrol2003，34，4： | 1 |
| 17 | Incidentally discovered adrenal myelolipoma: report on 3 operated patients and update of the literature 显示文摘 | PORCARO AB NOVELLA G FICARRA V | 2002 | Arch Ital Urol Androl2002，74，： | 1 |
| 18 | MRI characteristics of the uter- ine junctional zone:from normal to the diagnosis of adenomyosis显示文摘 | Novellas S Chassang M Delotte J | 2011 | A JR Am J Roentgenol2011，196，5： | 1 |
| 19 | Continuous versus inpatient prophylaxis of the first episode of spontaneous bacterial peritonitis with norfloxacin 显示文摘 | Novella M Sola R Soriano G | 1997 | Hepatology1997，25，3： | 1 |
| 20 | HD diesel engine equipped with a bottoming Rankine cycle as a waste heat recovery system(Part 1): Study and analysis of the waste heat energy显示文摘 | Dolz V Novella R Garcla A | 2012 | Applied Thermal Engineering2012，36，： | 1 |
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