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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Management of advanced non-small-cell lung cancer, the potential role of gemcitabine显示文摘 | Noble S Faulds D | 1999 | Health Outcomes1999，5，3： | 3 |
| 3 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 4 | Zoledronic acid 显示文摘 | Cheer SM Noble S | 2001 | Drugs2001，61，6： | 2 |
| 5 | Assessment of intubating conditions in adults after inducaion with propofol and varying doses of remifentanil显示文摘 | Crant S Noble S Woods A | 1998 | Br J Anaesth1998，81，4： | 1 |
| 6 | Tacrelimus ointment: a review of its use in atopic dermatitis and its clinical potential in other inflammatory skin conditions 显示文摘 | Simpsn D Noble S | 2005 | Drugs2005，65，6： | 1 |
| 7 | Fatigue of precipitate strengthened Cu-Ni-Sialloy显示文摘 | Loekyer S A Noble F W | 1999 | Mater Sci Techn1999，15，： | 1 |
| 8 | Human adenoviruses and coliphages in urban runoff-impacted coastal waters of Southern California显示文摘 | JIANG S NOBLE R CHU W | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 9 | 显示文摘 | Lockyer S A Noble F W | 1994 | Mater Sci1994，29，： | 1 |
| 10 | Evaluation of a general practitioner with special interest service for dermatology:randomised controlled trial显示文摘 | Salisbury C Noble A Horrocks S | 2005 | BM J2005，331，： | 1 |
| 11 | Interpreting unary, binary, and ternary mixture permeation across a SAPO-34 membrane with loading-dependent Maxwell-Stefan diffusivities 显示文摘 | Li S Falconer J L Noble R D | 2007 | J Phys Chem C2007，111，： | 1 |
| 12 | Tacrolimus ointment: a review of its use in atopic dermatitis and its clinical potential in other inflammatory skin conditions显示文摘 | Simpson D Noble S | 2005 | Drugs2005，65，6： | 1 |
| 13 | Aromatase expression in endometriosis显示文摘 | Simpson ER John A | 1996 | J Clin Endocrinol Metab1996，81，： | 1 |
| 14 | Aromatase expression in endometrosis显示文摘 | Noble L S Simp son ER Johns A | 1996 | Clin Endocrino Metab1996，81，1： | 1 |
| 15 | Microstructural stability during low temperature exposure of alloys within the Al-Li-Cu-Mg system显示文摘 | Katsikis S Noble B Harris S J | 2008 | Materials Science and Engineering2008，485，12： | 1 |
| 16 | Liver homeostasis with high-intensity ultrasound: repair and healing显示文摘 | Vaezy S Noble M L Keshavarzi A | 2004 | J Ultrasound Med2004，23，2： | 1 |
| 17 | Eptifibatide: a review of its use in patients with acute coronary syndromes and/or undergoing percutaneous coronary intervention 显示文摘 | Goa KL Noble S | 1999 | Drugs1999，57，3： | 1 |
| 18 | Relationship hindrance: Why would consumers not want a relationship with a retailer?显示文摘 | Noble S M and Phillips J | 2004 | Journal of Retailing2004，80，： | 1 |
| 19 | On plane graphs with link component number equal to the nullity显示文摘 | LIN Y F NOBLE S D JINX A | 2012 | Discrete Appl Math2012，160，9： | 1 |
| 20 | The Influence of C2C Communications in Online Brand Communities on Customer Purchase Behavior显示文摘 | Adjei M Noble S Noble C | | 0，，05： | 1 |
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