|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 3 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 4 | Maturation effects on absolute biomarker concentration in a suite of coals and associated vitrinite concentrates 显示文摘 | Dzou L I P Noble R A | 1995 | Org Geochemistry1995，23，7： | 2 |
| 5 | Configurational isomerization in sedimentary bicyclic alkanes 显示文摘 | Noble R A Alexander R Kagi R I | 1987 | Org Geochem1987，11，3： | 1 |
| 6 | Identification of some diterpenoid hydrocarbons in petroleum显示文摘 | Noble R A Alexander R Kagi R I | 1986 | Organic Geochemistry1986，10，： | 1 |
| 7 | Myocardial bridging and milk effect of the left anterior descending artery: nomalvariant or obstruction 显示文摘 | Noble J Bourassa MG Pettclerde R | 1976 | Am J Cardiol1976，37，： | 1 |
| 8 | Human adenoviruses and coliphages in urban runoff-impacted coastal waters of Southern California显示文摘 | JIANG S NOBLE R CHU W | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 9 | The impact of residual coagulant on downstream treatment process 显示文摘 | Lees E J Noble B Hewitt R | 2001 | Environment Technology2001，22，1： | 1 |
| 10 | Myocardial bridging and milking effect of the left anterior descending coronary artery: Nor- mal variant or obstruction 显示文摘 | Noble J Bourassa MG Petitclere R | 1976 | Am J Cardio1976，37，7： | 1 |
| 11 | Fabrication of 'hairy' colloidosomes with shells of polymeric microrods显示文摘 | Noble P F Cayre O J Alargova R G | 2004 | Journal of the American Chemical Society2004，126，26： | 1 |
| 12 | Rapid one-step quantitative reverse transcriptase PCR assay with competitive internal positive control for detection of enteroviruses in environmental samples 显示文摘 | GREGORY J B LITAKER R W NOBLE R T | 2006 | Appl Environ Microbiol2006，72，6： | 1 |
| 13 | Traumatic brain injury, in the rat:characterization of a lateral fluid-percussion model 显示文摘 | Mclntosh TK Vink R Noble L | 1989 | Neuroscience1989，28，： | 1 |
| 14 | Enteroviruses detected by reverse transcriptase polymerase chain reaction from the coastal waters of Santa Monica Bay, California: Low correlation to bacterial indicator levels显示文摘 | NOBLE R T FUHRMAN J A | 2001 | Hydrobiologia2001，460，： | 1 |
| 15 | Interpreting unary, binary, and ternary mixture permeation across a SAPO-34 membrane with loading-dependent Maxwell-Stefan diffusivities 显示文摘 | Li S Falconer J L Noble R D | 2007 | J Phys Chem C2007，111，： | 1 |
| 16 | Role of chance observations in chemotherapy : Vincarosea 显示文摘 | Noble R L Beer C T Cutts J H | 1958 | Ann N Y Acda Sci1958，76，3： | 1 |
| 17 | Review of vacuum cooling of mushrooms 显示文摘 | NOBLE R A | 1985 | Mushroom Journal1985，149，： | 1 |
| 18 | Tetracyclic diterpenoid hydrocarbons in some Australian coals, sediments and crude oils显示文摘 | Noble R A Alexander R Kagi R l | 1985 | Geochimica et Cosmochimica Acta1985，49，10： | 1 |
| 19 | Myocardial bridging and milkimg effect of the left anterior descending coronary artery : nomal variant or obstruction?显示文摘 | Noble J Bourassa MG Petitclerc R | 1976 | Am J Cardlol1976，37，7： | 1 |
| 20 | Effects of impurities on CO2/CH4 separations through SAPO-34 membranes显示文摘 | LIS G ALVARADO G NOBLE R D | 2005 | J Membr Sci2005，251，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员