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| 1 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 3 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 4 | Mid-infrared chalcogenide microfiber knot resonators显示文摘A novel type of mid-IR microresonator,the chalcogenide glass(ChG)microfiber knot resonator(MKR),is demonstrated,showing easy fabrication,fiber-compatible features,resonance tunability,and high robustness.ChG micro fibers with typical diameters around 3μm are taper-drawn from As2S3 glass fibers and assembled into MKRs in liquid without surface damage.The measured Q factor of a typical 824μm diameter ChG MKR is about 2.84×104 at the wavelength of 4469.14 nm.The free spectral range(FSR)of the MKR can be tuned from2.0 nm(28.4 GHz)to 9.6 nm(135.9 GHz)by tightening the knot structure in liquid.Benefitting from the high thermal expansion coefficient of As2S3 glass,the MKR exhibits a thermal tuning rate of 110 pm·℃^-1 at the resonance peak.When embedded in polymethyl methacrylate(PMMA)film,a 551μm diameter MKR retains a Q factor of 1.1×10^4.The ChG MKRs demonstrated here are highly promising for resonator-based optical technologies and applications in the mid-IR spectral range. | YU XIE DAWEI CAI HAO WU JING PAN NING ZHOU CHENGUANG XIN SHAOLIANG YU PAN WANG XIAOSHUN JIANG JIANRONG QIU XIN GUO LIMIN TONG | 2020 | Photonics Research2020，8，4： | 3 |
| 5 | Degradation of acid fuchsine by a modified electro-Fenton system with magnetic stirring as oxygen supplying显示文摘The current modified electro-Fenton system was designed to develop a more convenient and efficient undivided system for practical wastewater treatment.The system adopted a cathode portion that employed magnetic stirring instead of common oxygen gas difflusion or gas sparging to supply oxygen gas for the electrolyte solution.Key factors influencing the cathode fabrication and activity were investigated.The degradation of acid fuchsine with a self-made graphite-polytetrafluorethylene cathode was studied using a spectrophotometer.It was found that the cathode generated hydrogen peroxide with high current efficiency and the hydrogen peroxide yield of the cathode did not decay after 10 times reuse.With the Pt anode at a ferrous ion concentration of 0.5 mmol/L,a pH of 3,and using magnetic stirring,dye decolorization could be rapidly accomplished but the destruction of benzene rings and intermediates was fairly difficult.With a Fe anode,dye degradation was more complete. | Yiping Sheng,Limin Zhen,Xiuli Wang,Ning Li,Qi Tong College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,China. | 2010 | Journal of Environmental Sciences2010，22，4： | 2 |
| 6 | Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population:a case-control study显示文摘Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer susceptibility.Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) risk.This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.Methods:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese population.Results:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC risk.Conclusion:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population. | Limin Miao Lihua Wang Longbiao Zhu Jiangbo Du Xun Zhu Yuming Niu Ruixia Wang Zhibin Hu Ning Chen Hongbing Shen Hongxia Ma | 2016 | Chinese Journal of Cancer2016，35，11： | 2 |
| 7 | Coalfield structure and structural controls on coal in China显示文摘The occurrence of coal-bearing strata in a variety of coal-bearing basins of China is characterized by late tectonic deformation and remarkable spatial and geochronologic differences.The main controlling factors,which determine the tectonic framework of coalfields,include the geodynamic environment,tectonic evolution,deep structures,tectonic stress,and lithologic combination of the coal measures.The Chinese continent has experienced multi-stage tectonic movements since the Late Paleozoic.The spatial and temporal heterogeneity of its continental tectonic evolution,the complexity of its basement properties,and its stratigraphic configurations control the tectonic framework of its coalfields’present complex and orderly patterns.The concept of coal occurrence structural units is proposed in this paper and is defined as the structural zoning of coal occurrence.China’s coalfields are divided into five coal occurrence structural areas,and the structural characteristics of the coalfields in five main coal occurrence areas throughout the country are summarized.Based on the analysis of the relationship between the structure characteristics and occurrence of coal in these coalfields,the coal-controlling structures are divided into six groups:extensional structural styles,compressional structural styles,shearing and rotational structural styles,inverted structural styles,sliding structural styles,and syn-depositional structural styles.In addition,the distribution of coal-controlling structural styles is briefly summarized in this paper. | Daiyong Cao Anmin Wang Shuzheng Ning Huantong Li Aijun Guo Limin Chen Kang Liu Jieqing Tan Zhihong Zheng | 2020 | International Journal of Coal Science & Technology2020，7，2： | 2 |
| 8 | Evolving strategies for marine enzyme engineering:recent advances on the molecular modification of alginate lyase显示文摘Alginate,an acidic polysaccharide,is formed byβ-D-mannuronate(M)andα-L-guluronate(G).As a type of polysaccharide lyase,alginate lyase can efficiently degrade alginate into alginate oligosaccharides,having potential applications in the food,medicine,and agriculture fields.However,the application of alginate lyase has been limited due to its low catalytic efficiency and poor temperature stability.In recent years,various structural features of alginate lyase have been determined,resulting in modification strategies that can increase the applicability of alginate lyase,making it important to summarize and discuss the current evidence.In this review,we summarized the structural features and catalytic mechanisms of alginate lyase.Molecular modification strategies,such as rational design,directed evolution,conserved domain recombination,and non-catalytic domain truncation,are also described in detail.Lastly,the application of alginate lyase is discussed.This comprehensive summary can inform future applications of alginate lyases. | Shengsheng Cao Qian Li Yinxiao Xu Tiancheng Tang Limin Ning Benwei Zhu | 2022 | Marine Life Science & Technology2022，4，1： | 2 |
| 9 | Prevalence and conrtol of diabetes in Chinese adults显示文摘 | Yu xu Limin Wang Guang Ning | 2013 | JAMA2013，310，9： | 1 |
| 10 | Biomimetic Ti-6Al-4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration显示文摘Titanium-based scaffolds are widely used implant materials for bone defect treatment.However,the unmatched biomechanics and poor bioactivities of conventional titanium-based implants usually lead to insufficient bone integration.To tackle these challenges,it is critical to develop novel titanium-based scaffolds that meet the bioadaptive requirements for load-bearing critical bone defects.Herein,inspired by the microstructure and mechanical properties of natural bone tissue,we developed a Ti-6Al-4V alloy(TC4)/gelatin methacrylate(GelMA)hybrid scaffold with dual bionic features(GMPT)for bone defect repair.GMPT is composed of a hard 3D-printed porous TC4 metal scaffold(PT)backbone,which mimics the microstructure and mechanical properties of natural cancellous bone,and a soft GelMA hydrogel matrix infiltrated into the pores of PT that mimics the microenvironment of the extracellular matrix.Ascribed to the unique dual bionic design,the resultant GMPT demonstrates better osteogenic and angiogenic capabilities than PT,as confirmed by the in vitro and rabbit radius bone defect experimental results.Moreover,controlling the concentration of GelMA(10%)in GMPT can further improve the osteogenesis and angiogenesis of GMPT.The fundamental mechanisms were revealed by RNA-Seq analysis,which showed that the concentration of GelMA significantly influenced the expression of osteogenesis-and angiogenesis-related genes via the Pi3K/Akt/mTOR pathway.The results of this work indicate that our dual bionic implant design represents a promising strategy for the restoration of large bone defects. | Limin Ma Xiaolan Wang Ye Zhou Xiongfa Ji Shi Cheng Dong Bian Lei Fan Lei Zhou Chengyun Ning Yu Zhang | 2021 | Bioactive Materials2021，6，10： | 1 |
| 11 | Synthesis and Characterization of Tatraazaparacycl-ophane Disul-lone显示文摘 | YangYating YangBingqin LiMin Ning Wei Bai Yinjuan Li Jianli | 2008 | Synthetic Communications2008，28，： | 1 |
| 12 | Studies on electrospun nylon-6/chitosan complex nanofiber interactions显示文摘 | Haitao Zhang Shubai Li Christopher J. Branford White Xin Ning Huali Nie Limin Zhu | 2009 | Electrochimica Acta2009，，24： | 1 |
| 13 | Electrochemical corrosion behavior of Mg–5Al–0.4Mn– x Nd in NaCl solution显示文摘 | Ning Liu Jianli Wang Lidong Wang Yaoming Wu Limin Wang | 2009 | Corrosion Science2009，，6： | 1 |
| 14 | Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats显示文摘Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries(PNIs).However,conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity.We propose the development of biocompatible electroconductive hydrogels(ECHs)that are identical to a surgical dressing in this study.Based on excellent adhesive and self-healing properties,the thin film-like dressing can be easily attached to the injured nerve fibers,automatically warps a tubular structure without requiring any invasive techniques.The ECH offers an intimate and stable electrical bridge coupling with the electrogenic nerve tissues.The in vitro experiments indicated that the ECH promoted the migration and adhesion of the Schwann cells.Furthermore,the ECH facilitated axonal regeneration and remyelination in vitro and in vivo through the MEK/ERK pathway,thus preventing muscle denervation atrophy while retaining functional recovery.The results of this study are likely to facilitate the development of non-invasive treatment techniques for PNIs in diabetic patients utilizing electroconductive hydrogels. | Can Liu Lei Fan Zhenming Tian Huiquan Wen Lei Zhou Pengfei Guan Yian Luo Chuncheung Chan Guoxin Tan Chengyun Ning Limin Rong Bin Liu | 2021 | Bioactive Materials2021，6，11： | 1 |
| 15 | Electrochemical Method to Characterize Multidrug Resistance显示文摘 | LU Shan NING Limin GAO Tao WU Xiaolan YIN Yongmei LI Genxi | 2014 | Chemical Research in Chinese Universities2014，30，3： | 1 |
| 16 | Dark dimer mode excitation and strong coupling With a nanorod dipole显示文摘We theoretically investigate dark dimer mode excitation and strong coupling with a nanorod dipole. Efficient excitation of a dark mode in a gold(Au) nanorod dimer using an electric dipole can be achieved by an optimal overlap between the dipole moment and dark modal field. By replacing the dipole emitter with an Au nanorod, a plane wave excited dipole mode in the nanorod can be effectively coupled to the dark dimer mode through nearfield interaction. At a 10-nm separation of the nanorod and the dimer, plasmonic interaction between dipole-dark modes enters the strong coupling regime with a Rabi-like splitting of 219.2 meV, which is further evidenced by the anticrossing feature and Rabi-like oscillation of electromagnetic energy of the coupled modes. Our results propose an efficient approach to far-field activating dark modes in coupled nanorod dimers and exchanging plasmonic excitations at nanoscale, which may open new opportunities for nanoplasmonic applications such as nanolasers or nanosensors. | YIXIAO GAO NING ZHOU ZHANGXING SHI XIN GUO LIMIN TONG | 2018 | Photonics Research2018，6，9： | 1 |
| 17 | Reactivity of Organolithium Reagents to 2,3,4,5-Tetraphenylcyclopentadienone and Crystal Structures of Addition Products显示文摘 | ZHANG Xiaoyong HAN Limin ZHU Ning GAO Yuanyuan SUO Quanling | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
| 18 | Quantifying growth and breakage of agglomerates in fluid-particle flow using discrete particle method显示文摘The cohesive solids in liquid flows are featured by the dynamic growth and breakage of agglomerates, and the difficulties in the development, design and optimization of these systems are related to this significant feature.In this paper, discrete particle method is used to simulate a solid–liquid flow system including millions of cohesive particles, the growth rate and breakage rate of agglomerates are then systematically investigated. It was found that the most probable size of the agglomerates is determined by the balance of growth and breakage of the agglomerates the cross point of the lines of growth rate and breakage rate as a function of the particle numbers in an agglomerate, marks the most stable agglomerate size. The finding here provides a feasible way to quantify the dynamic behaviors of growth and breakage of agglomerates, and therefore offers the possibility of quantifying the effects of agglomerates on the hydrodynamics of fluid flows with cohesive particles. | Lingfeng Zhou Junwu Wang Wei Ge Shiwen Liu Jianhua Chen Ji xu Limin Wang Feiguo Chen Ning Yang Rongtao Zhou Lin Zhang Qi Chang Philippe Ricoux Alvaro Fernandez | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 0 |
| 19 | Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection显示文摘Dear Editor,The ongoing SARS-CoV-2 pandemic has lasted for 2 years,causing a severe global impact on social development.With widespread vaccinations,the number of new infections has dropped significantly,but with the emergence of diverse novel variants of concern(VOCs)and variants of interest(VOIs),there has been a second or third epidemic wave in many countries. | Wenhui Fan Shanshan Sun Ning Zhang Yuan Zhanq Pengtao Jiao Jian Wang George F.Gao Wenjun Liur Yuhai Bi Limin Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 20 | Correction to: Coalfield structure and structural controls on coal in China显示文摘Correction to:Int J Coal Sci Technol http://gffzzd3cc09b8251d45dfsbvoqxoo5ff656o5x.ffgz.tsg.suse.edu.cn/10.1007/s40789-020-00326-z The original publication of the article contains incorrect notes in Fig.1.The correct version of notes in Fig.1 is provided in this erratum.Fig.1 Tectonic framework of coalfields in China.1—Paleogene–Neogene coal measure;2—Lower Cretaceous coal measure;3—Early-Middle Jurassic coal measure;4—Upper Triassic coal measure;5—Carboniferous–Permian coal measure;6—First-level structural boundary;7—Second-level structural boundary;I:Eastern compound deformation zone;II:Western compressional deformation zone;III:Middle transitional deformation zone;NECCA:North East China coal occurrence area;NCCA:North China coal occurrence area;NWCCA:Northwest China coal occurrence Area;SCCA:South China coal occurrence area;YXCA:Yunnan-Tibet(Xizang)China coal occurrence area. | Daiyong Cao Anmin Wang Shuzheng Ning Huantong Li Aijun Guo Limin Chen Kang Liu Jieqing Tan Zhihong Zheng | 2020 | International Journal of Coal Science & Technology2020，7，2： | 0 |
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