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您的检索式：作者名="NIE XiongFeng"
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| 1 | 3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold显示文摘It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological environment.Herein,theβ-sheet-reinforced NP hydrogel is developed by copolymerizing methacrylated gelatin(GelMA)and methacrylated silk fibroin(SFMA)in aqueous solution,followed by ethanol treatment(named GelMA-SFMAAL).Theβ-sheets formed by SFMA can act as a stable physical crosslink to enhance the mechanical properties and prolong the degradation of the GelMA network.Importantly,the chemical crosslinking in the GelMA-SFMA hydrogel prevents excessive aggregation of hydrophobicβ-sheets,thereby avoiding the formation of brittle hydrogel.The obtained GelMA-SFMA-AL hydrogels exhibit considerably enhanced mechanical properties(Young's modulus:0.89–3.68 MPa;tensile strength:0.31–0.96 MPa;toughness:0.09–0.63 MJ/m^(3);compressive modulus:0.78–2.20 MPa;compressive strength:2.65–5.93 MPa)compared with GelMA-SFMA hydrogels(Young's modulus:0.04–0.13 MPa;tensile strength:0.04–0.07 MPa;toughness:0.01–0.02 MJ/m^(3);compressive modulus:0.03–0.09 MPa;compressive strength:0.30–0.64 MPa).A bilayer osteochondral scaffold is constructed via digital light processing(DLP)three-dimensiaonl(3D)printing technology,comprising GelMA-SFMA@diclofenac sodium(DS)-AL as the top layer and GelMA-SFMA@bioactive glass(BG)-AL as the bottom layer.The bilayer hydrogel scaffold is demonstrated to support cell attachment and spreading,and facilitate osteogenic differentiation of rat bone marrow stem cells in vitro.In vivo implantation experiment suggests this bilayer scaffold is promising to be used for osteochondral tissue regeneration. | ZHAO XinRui NIE XiongFeng ZHANG XiaoPing SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ZiYang LIU WenGuang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 2 | A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus显示文摘Developing a meniscus substitute mimicking the anisotropic mechanics(higher circumferential tensile modulus and lower compressive modulus)of native tissue remains a great challenge.In this work,based on the pendant group structure-dependent H-bonding strengthening mechanism,two kinds of amide-based H-bonding crosslinked hydrogels with distinct mechanical behaviors,that is,the flexible poly(N-acryloyl glycinamide)(PNAGA)and the ultra-stiff poly(N-acryloylsemicarbazide)(PNASC)hydrogels are employed to construct the biomimetic meniscus substitute.To this end,a gel microparticle-based self-thickening strategy is first proposed to fabricate PNASC(GMP-PNASC)high-modulus hydrogels skeleton by extrusion printing technology in mimicking the collagen fibers in native meniscus to resist the circumferential tensile stress.Then,the PNAGA hydrogel is infused into the PNASC skeleton to replicate the proteoglycan,providing a lower compressive modulus.By regulating the structural features at the interior and peripheral regions,the GMP-PNASC/PNAGA hydrogel meniscus scaffold with the higher tensile modulus(87.28±6.06 MPa)and lower compressive modulus(2.11±0.28 MPa)can be constructed.In vivo outcome at 12 weeks post-implantation of rabbit’s medial meniscectomy model confirms the effects of GMP-PNASC/PNAGA meniscus scaffold on alleviating the wear of articular cartilage and ameliorating the development of osteoarthritis(OA). | Ziyang Xu Qian Zhang Chuanchuan Fan Meng Xiao Rong Yang Yuan Yao Yang Wu Xiongfeng Nie Hongying Wang Wenguang Liu | 2023 | Bioactive Materials2023，，8： | 0 |
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