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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Co-delivery of doxorubicin and quercetin via mPEG-PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity显示文摘橡黄素(Que ) 是自然多功能的 bioflavonoid,并且为减少不利副作用并且提高化学疗法的药的反肿瘤功效显示出大潜力。然而,它的临床的申请在生理的系统由于很低的溶解度和结构的不稳定性被限制。此处,我们共同交付由开发 amphiphilic 聚合物包括的 biocompatible nanocarrier 的恐水病的橡黄素和吸水的 doxorubicin (纪录影片) , methoxy poly (乙烯乙二醇) 并且 poly (D, L-lactide-co-glycolide ) 分别地。反肿瘤和这个系统的预防功效被评估在细胞并且动物模型。我们说明的调查结果 Dox-Que nanoparticulate 明确的表达保护了正常脉管的 endothelial 房间免受免费的任何一个或 nanoparticulate 的伤害导致 doxorubicin 的 cytotoxicity 和增加的癌症房间死亡。与免费 doxorubicin 和它的 nanoformulation 相比,用我们的 nanosystem 的橡黄素和 doxorubicin 的合作交货 synergistically 禁止了肿瘤生长,当在浆液维持心脏的功能指示物的正常层次并且在心织物恢复组织病理学说的损坏时。这研究为提高反癌症药功效并且减少 nanoparticulate 表明有希望的策略正常纸巾上的导致化疗的毒性。 | Waseem Akhtar Qureshi Ruifang Zhao Hai Wang Tianjiao Ji Yanping Ding Ayesha Ihsan Ayeesha Mujeeb Guangjun Nie Yuliang Zhao | 2016 | Science Bulletin2016，61，21： | 9 |
| 3 | Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy显示文摘Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries.Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines.For example,platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis.In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment.This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation. | Yinlong Zhang Guangna Liu Jingyan Wei Guangjun Nie | 2018 | Frontiers of Medicine2018，12，6： | 4 |
| 4 | Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation显示文摘Accumulation and aggregation of β-amyloid(Aβ) peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer's disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity. | Aihua Yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang Chen Wang | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 5 | Antineoplastic activities of Gd@C_(82)(OH)_(22) nanoparticles: tumor microenvironment regulation显示文摘Malignant tumors are complex organs consisting of tumor cells and their microenvironment. Increasing evidence has shown that the tumor microenvironment is critical to the initiation and progression of tumors. Rational design of tumor therapies via targeting the tumor microenvironment to inhibit tumor growth is thus becoming a consensus strategy. Gd@C 82 (OH) 22 nanoparticles, as novel endohedral hydroxylated metallofullerenes, have been demonstrated to be a potent antitumor nanomedicine via targeting multiple factors in the tumor microenvironment. Gd@C 82 (OH) 22 nanoparticles possess excellent biocompatibility and remarkable antineoplastic activity, as a result not of direct tumor cytotoxicity but of their diverse biological effects, including antioxidation, immune activation, angiogenesis inhibition, imprisoning cancer cells, and reversal of drug-resistance. In this article, we summarize the unique nanoscale physiochemical properties and the antineoplastic activities of Gd@C 82 (OH) 22 nanoparticles, and focus on the mechanisms underlying their regulation of the tumor microenvironment. | LI YiYe TIAN YanHuan NIE GuangJun | 2012 | Science China(Life Sciences)2012，55，10： | 2 |
| 6 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 7 | Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer显示文摘Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance. | Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai Rui Dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu | 2022 | Bioactive Materials2022，7，7： | 1 |
| 8 | Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives显示文摘 | Zhongbing Lu Guangjun Nie Peter S Belton | 2006 | Neurochem Int2006，48，4： | 1 |
| 9 | Molecularly engineered tumor acidity-responsive plant toxin gelonin for safe and efficient cancer therapy显示文摘Due to the unsatisfactory therapeutic efficacy and inexorable side effects of small molecule antineoplastic agents,extensive efforts have been devoted to the development of more potent macromolecular agents with highspecificity.Gelonin is a plant-derived protein toxin that exhibits robust antitumor effect via inactivating ribosomesand inhibiting protein synthesis.Nonetheless,its poor internalization ability to tumor cells has compromisedthe therapeutic promise of gelonin.In this study,a tumor acidity-responsive intracellular protein deliverysystem-functional gelonin(Trx-pHLIP-Gelonin,TpG)composed of a thioredoxin(Trx)tag,a pH low insertionpeptide(pHLIP)and gelonin,was designed and obtained by genetic recombination technique for the first time.TpG could effectively enter into tumor cells under weakly acidic conditions and markedly suppress tumor cellproliferation via triggering cell apoptosis and inhibiting protein synthesis.Most importantly,treatment byintravenous injection into subcutaneous SKOV3 solid tumors in a mouse model showed that TpG was much moreeffective than gelonin in curtailing tumor growth rates with negligible toxicity.Collectively,our present worksuggests that the tumor acidity-targeted delivery manner endowed by pHLIP offers a new avenue for efficientdelivery of other bioactive substances to acidic diseased tissues. | Guo-Bin Ding Chenchen Zhu Qian Wang Huiyan Cao Bin-Chun Li Peng Yang Roland H.Stauber Guangjun Nie Zhuoyu Li | 2022 | Bioactive Materials2022，7，12： | 1 |
| 10 | Analytical methods for nano-bio interface interactions显示文摘Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level. | Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie | 2016 | Science China Chemistry2016，59，11： | 1 |
| 11 | Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives显示文摘 | LU Zhongbing NIE Guangjun BELTON P S | 2006 | Neurochem Int2006，48，4： | 1 |
| 12 | Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives 显示文摘 | Lu Zhongbing Nie Guangjun Peter S Behon etal | 2006 | Neurochem Int2006，48，4： | 1 |
| 13 | Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles显示文摘 | Hai Wang Ying Zhao Yan Wu Yu-lin Hu Kaihui Nan Guangjun Nie Hao Chen | 2011 | Biomaterials2011，，32： | 1 |
| 14 | Precise design of nanomedicines: perspectives for cancer treatment显示文摘Nanomedicine is a field in which nanomaterials and nanotechnology are applied to improve or create medications.Combining knowledge in various disciplines including nanoscience,biological science,advanced materials and pharmacy,the current interests in nanomedicine mainly focus on exploiting nanomaterials for drug delivery in order to improve the efficacy or safety of conventional treatments(chemical drugs,biological drugs,combination therapies,etc.).In recent years,increasing effort has been directed towards a more precise's understanding in nanomedicine.This includes not only accurate characterization of existing nanomedicines regarding their intrinsic properties and their biological effects,but also precise design of novel nanomedicines that are able to address diseases in a smart,individualized and safe manner.Taking anti-cancer therapy. | Jing Wang Yiye Li Guangjun Nie Yuliang Zhao | 2019 | National Science Review2019，6，6： | 0 |
| 15 | Self-assembly of CXCR4 antagonist peptide-docetaxel conjugates for breast tumor multi-organ metastasis inhibition显示文摘As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for decades.However,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4(CXCR4)expression during the treatment.Herein,we conjugated CXCR4 antagonist peptide(CTCE)with DTX(termed CTCE-DTX)as an anti-metastasis agent to treat breast cancer.CTCE-DTX could selfassemble to nanoparticles,targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX efficacy.Thus,the CTCE-DTX NPs achieved promising efficacy on inhibiting both bonespecific metastasis and lung metastasis of triple-negative breast cancer.Our work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy. | Chen Li Jiayan Lang Yazhou Wang Zhaoxia Cheng Mali Zu Fenfen Li Jingyi Sun Yating Deng Tianjiao Ji Guangjun Nie Ying Zhao | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 16 | The accurate localization of fluorescent nanoparticle Au-Ft in nu/nu mice kidney显示文摘Au-Ft,as a green synthesized nanoparticle,is composed of a ferritin nanocage enclosing a pair of Au nanoclusters inside.Our previous study has demonstrated that Au-Ft can be an excellentfluorescent probe for whole body imaging of mice with kidney specific targeting.But,the accuratelocalization of Au-Ft in kidney is still absent.In the current study,we detected and assessed the cellular and subcellular localization of Au-Ft in renal cortex and medulla of nu/nu mice after tailvein injection by using Nuance optical system(CRi,Woburn,USA)and inForm intelligent image analysis soft ware based on single cell segmentation.We obtained the fluorescence intensity and cellular location of kidney-targeting Au-Ft probe in particular cell of renal glomerulus or renaltubules,which provided valuable proofs to clarify the mechanism of Au-Ft selective enrichment in kidney and the associated metabolic processes. | Hui Yang Cuji Sun Jun Jia Guangjun Nie Zhenyu Wu | 2014 | Journal of Innovative Optical Health Sciences2014，7，3： | 0 |
| 17 | Intelligent nanomaterials for cancer therapy:recent progresses and future possibilities显示文摘Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy development.Empowered by the recent progresses of nanobiotechnology,a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated na-ture of cancer.With rationally designed multifunctionality and programmable assembly of functional subunits,the in vivo behaviors of intelligent nanosystems have become increasingly tunable,making them more efficient in performing sophisticated actions in physiological and path-ological microenvironments.In recent years,intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery,biological barrier circumvention,multi-responsive tumor sensing and drug release,as well as convergence with precise medication approaches such as personalized tumor vaccines.On the other hand,the increasing system complexity of anti-cancer nanomedicines also pose significant challenges in charac-terization,monitoring and clinical use,requesting a more comprehensive and dynamic understanding of nano-bio interactions.This review aims to briefly summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery,tumor immunotherapy and temporospatially specific tumor imaging,as well as impor-tant advances of our knowledge on their interaction with biological systems.In the perspective of clinical translation,we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nano-materials,highlighting the critical importance clinically-oriented system design. | Jing Wang Yuliang Zhao Guangjun Nie | 2023 | Medical Review2023，3，4： | 0 |
| 18 | Tumor-discriminating Nanoceria Antioxidant Enables Protection Against Acute Kidney Injury Without Compromising Chemotherapeutic Effects显示文摘Acute kidney injury is one of the most troublesome and lethal adverse effects in patients receiving chemotherapy.Conventional approaches that mitigate the toxicity of chemotherapeutic agents,however,also consequently compromise their tumorkilling efficacy.In order to overcome this dilemma. | WANG Jing NIE Guangjun ZHAO Yuliang | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 19 | Cascade adsorptive separation of light hydrocarbons by commercial zeolites显示文摘Adsorptive separation of light hydrocarbons by porous solids provides an energy-efficient alternative to state-of-the-art cryogenic distillation.However,an optimal balance between the cost,performance and stability of the sorbent material is yet to be achieved for industrial applications.Here,we report the efficient separation of C2 and C3 hydrocarbons by a faujasite zeolite(Na-X,Si/Al=1.23).A tandem configuration of two fixed-beds packed with Na-X affords complete dynamic separation of the ternary mixture of C_(2)H_(2)/C_(2)H_(4)/C_(2)H_(6)(1/49.5/49.5;v/v/v)under ambient conditions.Pressure-swing desorption on the latter fixed-bed gives ethylene(>99.50%,1.80 mmol g^(-1))and ethane(>99.99%,1.41 mmol g^(-1)).In situ synchrotron X-ray powder diffraction revealed the binding sites for C_(2)H_(2)and C_(2)H_(4)in Na-X.This study highlights the potential application of commercial zeolites for challenging industrial separations. | Shanshan Liu Yinlin Chen Bin Yue Yuanxin Nie Yuchao Chai Guangjun Wu Jiangnan Li Xue Han Sarah JDay Stephen PThompson Naijia Guan Sihai Yang Landong Li | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
| 20 | Nanotechnological strategies for prostate cancer imaging and diagnosis显示文摘The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and classification.Nanotechnology has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging modes.In this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging strategies.We also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives. | Thecla Trinity Wheeler Pei Cao Muhammad Daniyal Ghouri Tianjiao Ji Guangjun Nie Yuliang Zhao | 2022 | Science China Chemistry2022，65，8： | 0 |
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