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| 1 | Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling显示文摘We summarize from previous works the functions of circular vs. longitudinal muscle in esophageal peristaltic bolus transport using a mix of experimental data, the conservation laws of mechanics and mathematical modeling. Whereas circular muscle tone generates radial closure pressure to create a local peristaltic closure wave, longitudinal muscle tone has two functions, one physiological with mechanical implications, and one purely mechanical. Each of these functions independently reduces the tension of individual circular muscle fibers to maintain closure as a consequence of shortening of longitudinal muscle locally coordinated with increasing circular muscle tone. The physiological function is deduced by combining basic laws of mechanics with concurrent measurements of intraluminal pressure from manometry, and changes in cross sectional muscle area from endoluminal ultrasound from which local longitudinal shortening (LLS) can be accurately obtained. The purely mechanical function of LLS was discovered from mathematical modeling of peristaltic esophageal transport with the axial wall motion generated by LLS. Physiologically, LLS concentrates circular muscle fibers where closure pressure is highest. However, the mechanical function of LLS is to reduce the level of pressure required to maintain closure. The combined physiological and mechanical consequences of LLS are to reduce circular muscle fiber tension and power by as much as 1/10 what would be requiredfor peristalsis without the longitudinal muscle layer, a tremendous benefit that may explain the existence of longitudinal muscle fiber in the gut. We also review what is understood of the role of longitudinal muscle in esophageal emptying, reflux and pathology. | James G Brasseur Mark A Nicosia Anupam Pal Larry S Miller | 2007 | World Journal of Gastroenterology2007，13，9： | 4 |
| 2 | Urn cells:An experimental model for cervical mucus secretion显示文摘 | NICOSIA S V | 1979 | Laboratory Investigation1979，40，2： | 1 |
| 3 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 4 | Significance of Fas receptor protein expression in epithelial ovarian cancer显示文摘 | Reed J Hakam A Nicosia S V | 2005 | Hum Pathol2005，36，9： | 1 |
| 5 | Oncogenic pathways implicated in ovarian epithelial cancer显示文摘 | NICOSIA S V BAI J CHENG Q | 2003 | Hematol Oncol Clin North Am2003，17，4： | 1 |
| 6 | Isolation and characterization of vasoformative endothelial cells from the rat aorta显示文摘 | Nicosia R F Villaschi S Smith M | 1994 | In vitro Cel Dev Biol Anim1994，30，6： | 1 |
| 7 | Leukotrienes as mediators of asthma 显示文摘 | Nicosia S Capra V Rovati G E | 2001 | Pulm Parmacol Ther2001，14，1： | 1 |
| 8 | The mode of action of aescin on isolated veins: relationship with PGF2 alpha 显示文摘 | Longiave D Omini C Nicosia S | 1978 | Pharmacol Res Commun1978，10，2： | 1 |
| 9 | Isolation and characterization of vasoformative endothelial cells from the rat aorta显示文摘 | Nicosia RF Villaschi S Smith M | 1994 | In Vitro Cell Dev Biol Anim1994，30，6： | 1 |
| 10 | Leukotrlenes as Meditors of Asthma 显示文摘 | NICOSIA S CAPARA V ROVATI G E | 2001 | Pulmonary & Pharmacology & Therapeutics2001，14，： | 1 |
| 11 | Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro显示文摘 | Nicosai R Nicosia S Smith M | 1994 | Am J Pathology1994，145，5： | 1 |
| 12 | Robot control by using only joint position measurement显示文摘 | Nicosia S Tomei Q P | 1990 | IEEE Transactions on Automatic Control1990，35，9： | 1 |
| 13 | Carotid artery stenting in the presence of controlateral carotid occlusion:mind the hyperperfusion syndrome显示文摘 | NICOSIA A LEOTTA E MOSHIRI S | 2004 | Ital Heart J2004，5，： | 1 |
| 14 | The mode of action of aescin on isolated veins: relationship with PGF2α显示文摘 | Longiave D Omini C Nicosia S | 1978 | Pharmaeol Res Commun1978，10，2： | 1 |
| 15 | An evolutionary algorithm-based approach to robust analog circuit design using constrained mul- ti-objective optimization显示文摘 | Nicosia G Rinaudo S Sciacca E | 2008 | Knowledge-based Systems2008，21，3： | 1 |
| 16 | Larch arabinogalactan for dry eye protection and treatment of corneal lesions: investigations in rabbits 显示文摘 | Burgalassi S Nicosia N Monti D Falcone G Boldrini E Chetoni P | 2007 | J Ocul Pharmacol Ther2007，23，6： | 1 |
| 17 | Leukotrienes as mediators of asthma 显示文摘 | Nicosia S Capra V Rovati G E | 2001 | Pulm Parmacol Ther2001，14，1： | 1 |
| 18 | Cytological analysis of the urn cell complex of Sipunculus nudus before and after serum-induced secretion 显示文摘 | Nicosia S V Sowinski J M | 1995 | The Biological Bulletin1995，188，3： | 1 |
| 19 | Leukotrienes as medistors of asthma显示文摘 | Nicosia S Capra V Rovati G E | 2001 | Pulm Pharmacol Ther2001，14，1： | 1 |
| 20 | Scoring acute spinal cord injury:a study of the utility and limitations of five different grading systems 显示文摘 | Wells JD Nicosia S | 1995 | J Spinal Cord Med1995，18，1： | 1 |
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