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| 1 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 2 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 3 | RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family显示文摘控制基因规定为维持繁殖潜力在配偶子开发期间是重要的。在哺乳动物的精子发生的复杂过程期间,尽管有重翻译要求,男细菌房间为继续的生长和区别经历不活跃的抄写的扩大时期。因此,精子发生高度依赖基因表示的 posttranscriptional 规定的机制,由 RNA 有约束力的蛋白质(RBP ) 便于,它仍然保持富有地在整个这进程表示了。一如此的组蛋白质是 Musashi 家庭,以前在果蝇识别了睾丸细菌房间开发和成熟分裂的同样批评的管理者,并且也出现对在老鼠的精子开发和繁殖潜力重要。这评论在男细菌房间开发的范围以内描述 RBP 的角色和函数,集中于我们在精子发生的 Musashi 蛋白质的最近的知识。RBP 在房间以内利用的功能的机制在与模式的关系深入地亚 cellular 本地化和阶段特定的表示的,和意义被构画出, posttranscriptional 规定的影响也被加亮。当原来在果蝇和 Xenopus 描绘了,我们在干细胞功能和房间命运决心强调 RBP 的 Musashi 家庭的历史的角色,并且与我们微分角色的当前的理解和哺乳动物的 Musashi 蛋白质, Musashi-1 和 Musashi-2 的功能得出结论,与我们在精子发生的调查结果的一个主要焦点。这评论两个都作为男配偶子开发的主人管理者加亮 RBP 的必要贡献到 posttranscriptional 规定和 Musashi 家庭的重要性。 | Jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 4 | 在有症状的患者中,与传统危险因素相比,冠状动脉钙化积分能更准确地预测显著的冠状动脉狭窄:欧洲钙化性冠状动脉疾病研究显示文摘在这项回顾性研究中,研究人员评估了冠状动脉钙化积分相对于传统危险因素对显著狭窄(冠状动脉狭窄〉50%)的预测价值。方法与结果:纳入来自丹麦、法国、德国、意大利、西班牙和美国有症状的患者5515例,所有研究对象均进行危险因素评估、计算机断层冠状动脉造影(computed tomographic coronary angiogram,CTCA)或常规血管造影。 | 刘莉 叶鹏 Nicoll R Wiklund U Zhao Y Diederichsen A Mickley H Ovrehus K Zamorano P Gueret P Schmermund A Maffei E Cademartiri F Budoff M Henein M | 2016 | 中华高血压杂志2016，24，3： | 4 |
| 5 | Validation of computer - assisted manufacture of titanium plates for cranioplasty显示文摘 | Joffe JM Nicoll SR Richards R | 1999 | Int J Oral Maxillofac Surg1999，28，4： | 1 |
| 6 | Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in bums显示文摘 | John H Tinsley Nicole R | 2004 | Am J Physiol Lung Cell Mol Physiol2004，28，4： | 1 |
| 7 | Silent synapses during development of thalamocortical input 显示文摘 | CRAIR M C NICOLL R A | 1997 | Neuron1997，18，： | 1 |
| 8 | Population structure andcondition of Antarctic krill (Euphausia superba) off EastAntarctica (80-150°E) during the Austral summer of 1995/6显示文摘 | Nicol S Kitchener J King R | 2000 | Deep-sea Research II2000，47，1213： | 1 |
| 9 | Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns显示文摘 | John H Tinsley Nicole R | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，4： | 1 |
| 10 | Homozygosityfor a single base-pair mutation in the oocyte-specificGDF9 gene results in sterility in Thoka sheep显示文摘 | Nicol L Bishop S C Pong-Wong R | 2009 | Repro-duction2009，138，6： | 1 |
| 11 | Current advances in abscisic acid action and signalling显示文摘 | Jér?me Giraudat Fran?ois Parcy Nathalie Bertauche Fran?oise Gosti Jeffrey Leung Peter-Christian Morris Michelle Bouvier-Durand Nicole Vartanian | 1994 | Plant Molecular Biology1994，，5： | 1 |
| 12 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 13 | Endosialin( CD248 ) is a marker of tumor-associated pericytes in high-gradc显示文摘 | Nicole S David R | 2008 | Modem Pathology2008，21，： | 1 |
| 14 | Field evaluation of 64 apple rootstocks for orchard performance and fire blight resistance显示文摘 | NICOLE L R GENNARO F HERB S A | 2007 | Hortscience2007，42，7： | 1 |
| 15 | Ice reduces edema:a study of micicr- ovascular permeability in rats显示文摘 | Nicole DD John T Eileen R | 2002 | Journal of Bone & Joint Surgery2002，，9： | 1 |
| 16 | Influence of some artificial substrate on productivity and DRIS diagnosis of greenhouse tomatoes 显示文摘 | Nicole D R Jean C Leon E P | 1988 | Acta Horticulture1988，221，： | 1 |
| 17 | Validation of computer-assisted manufacture of titanium plates for cranioplasty 显示文摘 | Joffe JM Nicoll SR Richards R et-al | 1999 | Int J-Oral Maxilloface Surg1999，28，4： | 1 |
| 18 | Strain FAcl2, a dissimilatory iron-reducing member of the Anaeromyxobacter subgroup of Myxo- coccales显示文摘 | Nicole T Dirk R Werner L | 2003 | FEMS Microbiology Ecology2003，44，2： | 1 |
| 19 | Type Ⅱ and type Ⅲ monodeiodinase activities in the skin of untreated and propyhhiouracil2 treated cashmere goats显示文摘 | Villar D Nicol F Arthur J R | 2000 | Res Vet Sci2000，68，： | 1 |
| 20 | IFC and build- ing lifecycle management 显示文摘 | VANLANDE R NICOLLE C CRUZ C | 2008 | Automation in Construc- tion2008，18，： | 1 |
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