|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Extended broad-spectrum β-lactamases conferring transferable resistance to newer β-lactam agents in Enterobacteriaceae:hospital prevalence and susceptibility patterns显示文摘 | 2,Jarlier V Nicolas MH Fournier G | 1988 | Rev Infect Dis1988，10，： | 1 |
| 3 | Purification of the Escherichia coli K5 capsular polysaccharide and use of high-performance capillary electrophoresis to qualitative and quantitative monitor显示文摘 | NICOLA V | 2004 | Electrophoresis2004，25，1819： | 1 |
| 4 | Factors affecting dental fear in French children aged 5-12 years显示文摘 | Nicolas E Bessadet M Collado V | 2010 | Int J Paediatr Dent2010，20，5： | 1 |
| 5 | Increased topsoil mineral nutrient concentrations under exotic invasive plants in Belgium显示文摘 | Sonia V Nicolas D Pierre M | 2005 | Plant and soil2005，275，12： | 1 |
| 6 | Chemistry and biology of diazonamide A: Second total synthesis and biological investigations显示文摘 | Nicolaou K C Hao J Reddy M V | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 7 | Treatment of landfill leachate by reverse osmosis显示文摘 | Angelo C Rolando R Nicola V | 1999 | Water Research1999，33，3： | 1 |
| 8 | Environmental, social and economic information management for the evaluation of sustainability in urban areas: A system of indieators for Thessaloniki, Greece 显示文摘 | Nicolas M Charisios A Christos V | 2010 | Cities2010，，27： | 1 |
| 9 | Mechanism of antiandrogen action:key role of hsp90 in conformational change and transcriptional activity of the androgen receptor显示文摘 | Georget V Terouanne B Nicolas JC | | 0，，： | 1 |
| 10 | A comparative study of numerical schemes and modeling显示文摘 | Catherine A B Nicolas S V | 2004 | Wind Engineering2004，28，3： | 1 |
| 11 | Matching of Palmprlnts显示文摘 | Nicolae Duta Anil K J a in Kanti V Mardia | 2002 | Pattern Recognition Letters2002，23，： | 1 |
| 12 | Size effects in polycrystalline thin films analyzed by discrete dislocation plasticity 显示文摘 | NICOLA L GIESSEN E V NEEDLEMA A | 2005 | Thin Solid Films2005，479，12： | 1 |
| 13 | Challenges and Requirements for Introducing Impairment-Awareness into the Management and Control planes of ASON/GMPLS WDM Networks 显示文摘 | Martinez L V Ricardo Pinart Carolina Andriolli Nicola | 2006 | IEEE Communications Magazine2006，44，12： | 1 |
| 14 | Environmental and stomatal control of transpiration, canopy conductance and decoupling coefficient in young lemon trees under shading net显示文摘 | Nicolas E Barradas V L Ortuno M F | 2008 | Environmental and Experimental Botany2008，63，： | 1 |
| 15 | Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond 显示文摘 | Gabriella C Nicola V Silvana | 2007 | Acta Biomed2007，78，2： | 1 |
| 16 | Relationship of transfusion and infectious complication saftergastriccarcinomaoperations 显示文摘 | Pinto V Baldonedo R Nicolas C | 1991 | Transfusion1991，31，： | 1 |
| 17 | Temporal and light-based changes in carbon uptake and storage in the spring ephemeral Podophyllum peltatum (Berberidaceae) 显示文摘 | Constable J V H Peffer B J De Nicola D M | 2007 | Environmental and Experimental Botany2007，60，1： | 1 |
| 18 | Biological Signifi- cance of Decreased HSP27 in Human Atherosclerosis 显示文摘 | Martin - Ventura ]L Nicolas V Houard X | 2006 | Arterio- scler Thromb Vasc Biol2006，26，6： | 1 |
| 19 | Disaccharide mapping of chondroitin sulfate of different origins by high-performance capillary electrophoresis and high-performance liquid chromatography显示文摘 | Nicola V | | 0，，3： | 1 |
| 20 | A national cross-sectional survey of dental anxiety in the French adult population显示文摘 | Nicolas E Collado V Faulks D | 2007 | BMC Oral Health2007，7，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员