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| 1 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 3 | Potentiality of Pr3+- and Pr3++Ce3+- doped crystals for tunable UV upconversion lasers 显示文摘 | Nicolas S Descroix E Joubert M F | 2003 | Opt Mater2003，22，： | 2 |
| 4 | From azoospermia to macrozoospermia,a phenotypic continuum due to mutations in the ZMYND15 gene显示文摘Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing(WES),many genes have now been linked to severe sperm defects.A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C(AURKC)gene.Here,we studied a subject with a severe oligozoospermia and a phenotypic diagnosis of macrozoospermia.AURKC analysis did not reveal any deleterious variant.WES was then initiated which permitted to identify a homozygous loss of function variant in the zinc finger MYND-type containing 15(ZMYND15)gene.ZMYND15 has been described to serve as a switch for haploid gene expression,and mice devoid of ZMYND15 were shown to be sterile due to nonobstructive azoospermia(NOA).In man,ZMYND15 has been associated with NOA and severe oligozoospermia.We confirm here that the presence of a bi-allelic ZMYND15 variant induces a severe oligozoospermia.In addition,we show that severe oligozoospermia can be associated macrozoospermia,and that a phenotypic misdiagnosis is possible,potentially delaying the genetic diagnosis.In conclusion,genetic defects in ZMYND15 can induce complete NOA or severe oligozoospermia associated with a very severe teratozoospermia.In our experience,severe oligozoospermia is often associated with severe teratozoospermia and can sometimes be misinterpreted as macrozoospermia or globozoospermia.In these instances,specific AURKC or dpy-19 like 2(DPY19L2)diagnosis is usually negative and we recommend the direct use of a pan-genomic techniques such as WES. | Zine-Eddine Kherraf Caroline Cazin Florence Lestrade Jana Muronova Charles Coutton Christophe Arnoult Nicolas Thierry-Mieg Pierre F Ray | 2022 | Asian Journal of Andrology2022，24，3： | 2 |
| 5 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 6 | Pharmacokinetics and pharmacodynamics of amoxicillin-sulbactam,a novel aminopenicillin-beta-lactamase inhibitor combination against Escherichia coli显示文摘 | Bantar C Nicola F Arenoso H | 1999 | Antimicrob Agents Chemother1999，43，6： | 1 |
| 7 | Aerosol inorganic ions in a semiarid region on the southeastern Spanish Mediterranean coast显示文摘 | Nicolas J F Galindo N Yubero E | 2009 | Water Air and Soil Pollution2009，201，14： | 1 |
| 8 | Driving Blind:Strategic Decision-making in Small Companies显示文摘 | Brouthers K.D Andriessen F Nicolaes I | | 0，，： | 1 |
| 9 | Evaluation and application ofthe OILCROP-SUN model for sunflower in southern Italy 显示文摘 | MICHELE R NICOLA L ZINA F | 2003 | Ag-ricultural Systems2003，78，： | 1 |
| 10 | Questioning Authority: the Critical Link between Board Power and Process显示文摘 | Nicola F S | 2012 | Journal of Corporate Law2012，38，1： | 1 |
| 11 | Molecular and func- tional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells显示文摘 | De Bosscher K Hill C S Nicola's F J | 2004 | Biochem2004，379，： | 1 |
| 12 | Centrifuge modelling of pipe piles in sand under axial loads 显示文摘 | NICOLA A D E RANDOLPH M F | 1999 | Geotechnique1999，49，3： | 1 |
| 13 | Anthocyanin degrationin oxidizing grape musts显示文摘 | KADER F HALUK J P NICOLAS J P | 1994 | Journal of the Scicence of Food andAgriculture1994，46，： | 1 |
| 14 | Brief hypoxia before nomoxic reperfusion (postconditioning) protects the heart against ischemia - reperfusion injury by preventing mitochondria peroxide production and glutathione depletion 显示文摘 | Gaetano S Nicola DV Antonio F | 2005 | The FASEB Journal2005，19，： | 1 |
| 15 | Chemical biology of epothilones显示文摘 | Nicolaou KC Roschangar F Vourloumis D | 1998 | Angew Chem Int Ed1998，37，： | 1 |
| 16 | Localization of TREK-1,a two-pore-domain K^+ channel in the peripheral vestibular system of mouse and rat显示文摘 | Nicolas MT Lesage F Reyes R | 2004 | Brain Res2004，1017，12： | 1 |
| 17 | Environmental and stomatal control of transpiration, canopy conductance and decoupling coefficient in young lemon trees under shading net显示文摘 | Nicolas E Barradas V L Ortuno M F | 2008 | Environmental and Experimental Botany2008，63，： | 1 |
| 18 | Layer-by-layer films as a biomimetic reservoir for rhBMP--2 delivery: Controlled differentiation of myoblasts to osteoblasts显示文摘 | Crouzier T Ren K F Nicolas C | 2009 | Small2009，5，5： | 1 |
| 19 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T De Nicola F Guerrieri F Raffa G Fanciulli M | | Proceedings of the National Academy of Sciences(USA)0，，： | 1 |
| 20 | Transforming growth factor- beta expression in human placenta and placental bed and fetal growth restiction显示文摘 | Lyall F Simpson H Nicola BJ | 2001 | Am J Pathol2001，159，5： | 1 |
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