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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Differential expression of NK T cells Va24 J α Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy显示文摘 | Illes Z Kondo T Newcombe J | 2000 | J Immunol2000，164，8： | 1 |
| 3 | Double pulsed holography used to investigate noisy brakes 显示文摘 | FIELDHOUSE J D NEWCOMB T P | 1996 | Optics and Lasers in Engineering1996，25，6： | 1 |
| 4 | Does preoperative atrial fibrillation portend a poorer prognosis in patients undergoing isolated aortic valve replacement- A multicentre Australian study显示文摘 | Saxena A Dinh D T Reid C M Smith J A Shardey G C Newcomb A E | 2013 | Can J Cardiol2013，29，： | 1 |
| 5 | Incorporation of Reliability into Mechanistic-empirical Pavement Design显示文摘 | Timm D H Newcomb D E Galambos T V | 2000 | Journal of the Transportation Research Board2000，1730，： | 1 |
| 6 | Guidelines for power and time variables for microwave ablation in an in vivo porcine kidney显示文摘 | Hope W W Schmelzer T M Newcomb W L | 2009 | J Surg Res2009，153，2： | 1 |
| 7 | The effects of sexual partnership and relationship characteristics on three sexual risk variables in young men who have sex with men显示文摘 | Newcomb M E Ryan D T Garofalo R | 2014 | Archives of Sexual Behavior2014，43，1： | 1 |
| 8 | The impact of college on students 显示文摘 | FELDMAN K A NEWCOMB T M | 1969 | San Francisco: Jossey-Bass1969，，： | 1 |
| 9 | Channel suspendedsediment and fisheries:a synthesis for quantitative assessmentof risk and impact显示文摘 | NEWCOMBE C P JENSEN J O T | 1996 | North American Journal of FisheriesManagement1996，16，： | 1 |
| 10 | Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas 显示文摘 | Newcomb EW Alonso M Sung T | 2000 | Hum Pathol2000，31，： | 1 |
| 11 | Regulation of the DBP promote by PAR proteins and in leukemia cells bearing and E2A' HLF translocation 显示文摘 | Newcombe K Glassco T | 1998 | Biochem Biophy Res Commun1998，245，2： | 1 |
| 12 | Thermal effects and pressure distributions in brakes 显示文摘 | Day A J Tirovic M Newcomb T P | 1991 | Journal of Automo- bile Engineering1991，205，3： | 1 |
| 13 | Bioremediation of soils contaminated with explosives 显示文摘 | LEWIS T A NEWCOMBE D A CRAWFORD R L | 2004 | Journal of Environmental Management2004，70，4： | 1 |
| 14 | Some consequences of de-individuation in a group显示文摘 | Festing L Pepitone A Newcomb T | 1952 | Journal of Abnormal and Social Psychology1952，47，2： | 1 |
| 15 | The effects of cy- tokines on suppression of lymphocyte proliferation by dexa- methasone 显示文摘 | Creed T J Lee RW Newcomb PV | 2009 | J Immunol2009，183，1： | 1 |
| 16 | The dissipation of frictional energy from the interface of an annular disc brake显示文摘 | Day A J Newcomb T P | 1984 | Proceeding of the Institution of Mechanical Engineers Part D:Transport Engineering1984，198，11： | 1 |
| 17 | The dissipation of frictional energy from the interface of an annular disc brake 显示文摘 | Day A J Newcomb T P | 1984 | J Automobile Eng1984，198，： | 1 |
| 18 | Snow sports related head and spinal injuries:an eight-year survey from the neurotrauma centre for the Snowy Mountains,Australia显示文摘 | Siu T L T Chandran K N Newcombe R L | 2004 | J Clinical Neuroscience2004，11，3： | 1 |
| 19 | Channel Suspended Sediment and Fisheries: A synthesis for Quantitative Assessment of Risk and Impact显示文摘 | Newcombe C P Jensen J O T | 1996 | North American Journal of Fisheries Management1996，16，4： | 1 |
| 20 | The association of body size and large bowel cancer risk in Wisconsin(United States)women显示文摘 | Dietz A T Newcomb P A Marcus P M | 1995 | Cancer Causes Control1995，6，4： | 1 |
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