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| 1 | Pro-and anti-inflammatory cytokines profiles among Nigerian children infected with Plasmodium falciparum malaria显示文摘Objective:To examine array of some pro- and anti-inflammatory cytokines,namely, interleukin-4(IL-4),interleukin-10(IL-10),interferon-γ(IFN-γ),interleukin-5(IL-5), interleukin-6(IL-6),interleukin-12(IL-12) and tumor necrosis factor-α(TNF-α) concentrations in some Nigerians with falciparum malaria.Methods:Sera were obtained from the blood samples of 96 Nigerian children with Plasmodium falciparum infection.The sera were subjected to cytokine evaluation using commercial standard enzyme linked immunosorbent assay kits(Abcam,UK).Results:Mean pro-inflammatory cytokines in serum of children with uncomplicated and complicated malaria were IL-5 482.2 pg/mL versus 526.7 pg/mL,IL-6 98.8 pg/mL versus 82.6 pg/mL,IL-12 24.1 pg/mL versus 15.9 pg/mL,TNF-α107 pg/mL versus 511.7 pg/mL and IFN- 7 2.1 pg/mL versus 2.5 pg/mL.The anti-inflammatory cytokines status of IL-4 were 4.7 pg/mL versus 20.3 pg/mL,and IL-10 were 216 pg/mL versus 143.8 pg/mL in uncomplicated versus complicated/severe malaria cases.Participants with uncomplicated malaria had mean parasitaemia level of 3 158.9 parasites/μL while mean parasitaemia level for participants with complicated malaria was 12 550.5 parasite/μL and this difference was statistically significant(χ~2 =5 614.6,P<0.05).The difference between mean haemoglobin level for uncomplicated malaria(9.6 g/dL) and severe malaria(3.9 g/dL) was statistically significant (χ~2 = 2.3,P<0.05).The relationship between serum level of IL-6,IL-12,IFN-γ,IL-10 and IL-4 and ages showed positive correlation at r=0.92,0.99,0.86,0.95 and 0.85,respectively;while IL-5 and TNF-αhad negative correlation at r=-0.99 and -0.99,respectively.Conclusion: IL-4,IL-5,IL-6,IL-10,IL-12,TNF-αand IFN-γare involved in the immunopathology and immunoregulation of uncomplicated and complicated malaria infections.IL-6,IL-12,IFN-γand IL-10 depressed in complicated/severe malaria may not provide any protective immunity and may be indicators of poor prognosis in Plasmodium falciparum infected Nigerian children. | Nmorsi OPG Isaac C Ukwandu NCD Ohaneme BA | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，1： | 2 |
| 2 | Schistosoma haematobium and Plasmodium falciparum coinfection with protection against Plasmodium falciparum malaria in Nigerian children显示文摘Objective:Malaria remains the single leading killer of children in sub - Sahara Africa and Schistosomiasis is considered to be second to malaria in global importance.Co - infection of malaria and urinary schistosomiasis has been reported to exacerbate disease morbidity such as anaemia.In different part of the globe,the co - infection between malaria and schistosomiasis provides some protections on the infected persons.The protective effect of this co - infection elucidated immunologically using cytokines is lacking in our locality.Methods:Urine and blood samples obtained from the 160 volunteers were subjected to standard parasitological techniques for diagnosis of urinary schistosomiasis and malaria respectively.Blood samples collected from these volunteers comprising 80 children with schistosomiasis and malaria and the 80 children who had malaria only were subjected to cytokines concentration determination using commercial standard enzyme linked immunosorbent assay kits(Abeam,UK).Results:Eighty participants with co - infection had a mean malarial parasitaemia of 662±201.1μL while the 80 participants with only P.falciparum malaria had a mean malarial parasiteamia of 5943±3270.7μL.Also the volunteers had mean haemoglobin of 11.2 g/dL for co - infected individuals and 5.7 g/dL for participants with single infection of malaria.The serum cytokine levels of the children with S. haematobium and P.falciparum and only P.falciparum infection are as follows;interleukin - 4(16.6 pg/ mL versus 5.2 pg/mL),IL - 5(501.3 pg/mL versus 357.5 pg/mL);IL -8(2 550 pg/mL versus 309 pg/mL),IL - 10(273 pg/mL versus 290 pg/mL),TNF -α(25 pg/mL versus 290 pg/mL) and IFN -γ(21.9 pg/mL versus 2.5 pg/mL).The TNF -α/IL - 10 ratio is 7 for the children with co - infection while those with only P.falciparum malaria infection had a TNF -α/IL - 10 ratio of 0.9.Conclusion:We conclude that the elevated IL - 4,IL - 5,IL - 8 and IFN -γconcentration induced by schistosomiasis altered the Th1/Th 2 profile and protected the children against the morbidity and severity of malaria attack among the children with co - infection. | Nmorsi OPG Isaac C Ukwandu NCD Ekundayo AO Ekozien MI | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，2： | 2 |
| 3 | In vitro micronuelei tests to evaluate the genotoxicity of surface water under the influence of tanneries显示文摘 | Lemos AO Oliveira NCD Lemos CT | 2011 | Toxicol in Vitro2011，25，： | 1 |
| 4 | Microemulsion systerms applied to breakdown petroleum emulsions 显示文摘 | Tereza NCD Afonso A D N Everlane F M | 2001 | J Petrol Sci Engng2001，32，： | 1 |
| 5 | Report of a WHO consultation: Definition, diagnosis and classification of diabetes mellitus and its complications 显示文摘 | WHO NCD NCS | 1999 | Diabet Med1999，15，： | 1 |
| 6 | Time for global action on chronic disease显示文摘 | Australians for Global Action on NCDs | 2011 | Med J Aust2011，194，15： | 1 |
| 7 | Obesity: Preventing and managing the global rpidemic: teport of a WHO vonsultation on obesity显示文摘 | WHO/NUT/NCD | 1998 | Geneva1998，894，12： | 1 |
| 8 | Helicobacter pylori in Peptic Ulcer Disease显示文摘 | Disease NCD Po Hpi PU Yamada T Searle JG | 1994 | JAMA:The Journal of the American Medical Association1994，272，： | 1 |
| 9 | Accuracy of intraoperative assessment of acetabular prosthesis placement 显示文摘 | Douglas MH Geoffrey HFJ William NCD | 1998 | The Journal of arthroplasty1998，13，1： | 1 |
| 10 | Cardiovascular effects of marine omega-3 fatty acids显示文摘 | Palaniappan Saravanan NCD Erik B Schmidt Philip C Calder | 2010 | Lancet2010，375，： | 1 |
| 11 | Formation and repair of oxidative damage in the mitochondrial DNA显示文摘 | Muftuoglu M Mori MP Souza-Pinto NCD | 2014 | Mitochondrion2014，17，0： | 1 |
| 12 | Whole-body vibration decreases the proliferativeb response of T CD4+ cells in elderly individuals with knee osteoarthritis显示文摘 | Tossige-Gomes R Avelar NCD Simao AP | | 0，，12： | 1 |
| 13 | Obesity: Preventing and Managing the Global Epidemic,Peport of a WHO Consultation on Obesity 显示文摘 | WHO/NUT/NCD | 1997 | Geneva :WHO1997，，： | 1 |
| 14 | 你愿用笔画出湿地的自然吗? 来报名吧!显示文摘大家或许都听说过,海洋是“地球之心”,森林是“地球之肺”,那你知道“地球之肾”又是什么吗?没错,那就是湿地。“湿地”,泛指暂时或长期覆盖水深不超过2米的低地、土壤充水较多的草甸、以及低潮时水深不过6米的沿海地区,包括各种咸水淡水沼泽地、湿草甸、湖泊、河流以及泛洪平原、河口三角洲、泥炭地、湖海滩涂、河边洼地或漫滩、湿草原等。可别看湿地覆盖地球表面仅有6%, | NCD爱辉 | 2016 | 现代青年2016，0，8： | 0 |
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