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| 1 | Hydrogenation of naphthalene on NiMo- Ni- and Ru/Al203 catalysts: Langmuir-Hinshelwood kinetic modelling显示文摘 | Monteiro-Gezork A C A Natividad R Winterbottom J M | 2008 | Catalysis Today2008，130，24： | 1 |
| 2 | Interleukin-27 signaling promotes immunity against endogenously arising murine tumors 显示文摘 | NATIVIDAD K D JUNANKAR S R MOHD REDZWAN N | 2013 | PLoS One2013，8，57： | 1 |
| 3 | Hydrogenation of Naphthalene on NiMo-, Ni- and Ru/Al203 Catalysts: Langmuir-Hinshelwood Kinetic Modeling 显示文摘 | Monteiro-Gezork A C A Natividad R Winterbottom J M | 2008 | CatalToday2008，130，24： | 1 |
| 4 | Autoantibodies against IL- 17A,IL-17F,and IL-22 in patients with chronic mucocutaneous can- didiasis and autoimmune polyendocrine syndrome type I 显示文摘 | Puel A Doffinger R Natividad A | 2010 | J Exp Med2010，207，2： | 1 |
| 5 | Detection, quantification and genotyping of herpes simplex virus in cervicovaginal secretions by real-time PCR: a cross sectional survey显示文摘 | Aryee E A Bailey R L Natividad S A | 2005 | J Virol2005，2，1： | 1 |
| 6 | Quantification and genotyping of herpes simplex virus in cervicovaginal secretions by real-time PCR:a cross sectional survey显示文摘 | Aryee E A Bailey R L Natividad S A | 2005 | J Virol2005，2，： | 1 |
| 7 | Autoantibodies against IL-17A,IL-17F,and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I显示文摘 | Puel A Doffinger R Natividad A | 2010 | J Exp Med2010，207，2： | 1 |
| 8 | Characterization of trace metals in vegetables by graphite furnace atomic absorption spectrometry after closed vessel microwave digestion显示文摘 | Karima B Natividad R M Badredine S | 2009 | Food Chemistry2009，116，2： | 1 |
| 9 | Characterization of trace metals in vegetables by graphite furnaee atomic absorption spectrometry after closed vessel microwave digestion显示文摘 | KARIMA B NATIVIDAD R M BADREDINE S | 2009 | Food Chemis- try2009，116，2： | 1 |
| 10 | Autoantibodies against IL- 17A, IL- 17F, and IL- 22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syn- drome type I显示文摘 | PUEL A DOFFINGER R NATIVIDAD A | 2010 | J Exp Med2010，207，2： | 1 |
| 11 | Characterization of Trace Metals in Vegetables by Graphite Furnace Atomic Absorption Spectrometry after Closed Vessel Microwave Digestion显示文摘 | Karirna B Natividad R M Badredine S | 2009 | Food Chemistry2009，116，2： | 1 |
| 12 | Detection,quantification and genotyping of herpes simplex virus in cervicovaginal secretions by real-time PCR: a cross sectional survey显示文摘 | ARYEE E A BAILEY R L NATIVIDAD S A | 2005 | J Virol2005，79，2： | 1 |
| 13 | Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis- induced tubal factor infertility and disease severity 显示文摘 | Ohman H Bailey R Natividad A | 2012 | Hum Reprod2012，27，7： | 1 |
| 14 | Autoantibodies a- gainst IL-17A, IL-17F, and IL-22 in patients with chron- ic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I显示文摘 | Puel A Dtfffinger R Natividad A | 2010 | J Exp Med2010，207，2： | 1 |
| 15 | Scaling-out selective hydrogenation reactions: From single capillary reactor to monolith 显示文摘 | Natividad R Cruz-Olivares J Fishwick R P | 2007 | Fuel2007，86，： | 1 |
| 16 | Autoantibodies against IL-17 A, IL-17 F, and IL-22 in patients with chronic mucocutane?ous candidiasis and autoimmune polyendocrine syndrome type I 显示文摘 | Puel A Doffinger R Natividad A | 2010 | J Exp Med2010，207，2： | 1 |
| 17 | Enhancing the electrochemical Cr(VI) reduction in aqueous solution 显示文摘 | BARRERA-DAZ C LUGO-LUGO V ROA-MORALES G NATIVIDAD R MARTiNEZ-DELGADILLO S A | 2011 | Journal of Hazardous Materials2011，185，23： | 1 |
| 18 | 显示文摘 | Martinez S L Romero R Natividad R | 2014 | Catalysis Today2014，22，： | 1 |
| 19 | Autoantibodies against IL-17A,IL-17F,and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I显示文摘 | Puel A Doffinger R Natividad A | | 0，，： | 1 |
| 20 | MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos显示文摘BACKGROUND Colorectal cancer(CRC)ranks third in terms of incidence and second in mortality worldwide.In CRC,the silencing of mismatch repair genes,including the mutL homolog 1(hMLH1)has been linked to microsatellite instability(MSI),the lengthening or shortening of microsatellite repeats.Very limited data have been presented so far on the link of hMLH1 methylation and MSI in Southeast Asia populations with sporadic CRC,and on its clinical significance.AIM To investigate the significance of the MSI status and hMLH1 methylation in CRC Filipino patients.METHODS Fifty-four sporadic CRC patients with complete clinical data were included in this study.Genomic DNA from CRC tumor biopsies and their normal tissue counterparts were profiled for MSI by high resolution melting(HRM)analysis using the Bethesda Panel of Markers(BAT25,BAT26,D2S123,D5S346,and D17S250).hMLH1 methylation screening was performed using bisulfite conversion and methylation specific polymerase chain reaction.Statistical analysis was conducted to calculate their associations to clinicopathological characteristics and survival relevance(Kaplan-Meier curves and the log-rank test).RESULTS hMLH1 methylation was observed in 9%and 35%of CRC and normal samples,respectively.Higher incidence of consistently methylated hMLH1 found in both normal and CRC was noticed for relation to location of tumor(P<0.05).As for MSI status,D2S123 the most common unstable microsatellite and MSI-high(MSIH)was the most common MSI profile,counted for 46%and 50%of normal and CRC tissues,respectively.The presence of MSI-low(MSI-L)and microsatellite stable(MSS)was 43%and 11%for normal,and 31%and 19%for CRC samples.The mean month of patients’survival was shorter in patients whose normal and tumor tissues had methylated compared to those with unmethylated hMLH1 and with MSI-H compared to those with MSI-L/MSS(P<0.05).This was supported by significant difference in Kaplan-Meier with log-rank analysis.This data indicated that hMLH1 methylation and high MSI status have prognostic value.CONCLUSION This study showed the clinical significance of hMLH1 methylation and MSI status in sporadic CRC Filipino patients,especially in the normal part of the tumor. | Loraine Kay D Cabral Cynthia A Mapua Filipinas F Natividad Caecilia H C Sukowati Edgardo R Cortez Ma Luisa D Enriquez | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 0 |
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