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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Comparative analysis of proliferating cell nuclear antigen and epidermal growth factor receptor expression in glial tumours:correlation with histological grading显示文摘 | Mottolese M Natali PG Coli A | 1998 | Anticancer Res1998，18，3： | 2 |
| 3 | Human disease modeling with induced pluripotent stem cells显示文摘 | Alan Trounson Kelly A Shepard Natalie D DeWitt | 2012 | Current Opinion in Genetics & Development2012，，5： | 2 |
| 4 | Endoscopic ultrasound-fine needle injection for oncological therapy显示文摘The minimal invasiveness and precision of endoscopicultrasound(EUS) has lead to both its widespread use as a diagnostic and staging modality for gastrointestinal and pancreaticobiliary malignancies, and to its expand-ing role as a therapeutic modality. EUS-guided celiac plexus neurolysis is now a well-accepted modality for palliation of pain in patients with pancreatic cancer. EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described as methods of performing minimally invasive oncological therapy. EUS-fine needle injection may be performed as adjunctive, alternative, or palliative treatment. This review summarizes the studies to date that have described these methods. A literature search using the Pub Med/MEDLINE databases was performed. While most published studies to date are limited with disappointing outcomes, the concept of a role of EUS in oncological therapy seems promising. | Jeremy Kaplan Amaara Khalid Natalie Cosgrove Ayesha Soomro Syed Mohsin Mazhar Ali A Siddiqui | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 5 | Insulin resistance of stress:sites and mechanism显示文摘 | Brandi LS Santoro D Natali A | 1993 | Clin Sci1993，85，5： | 1 |
| 6 | A Cognitive Model of Crowd Behavior Based on Social Comparison Theory 显示文摘 | Gal A Kaminka Natalie Fridman | 2006 | American Association for Artificial Intelligence (S0738-4602)2006，7，： | 1 |
| 7 | Endothelin receptors as novel targets in tumor therapy显示文摘 | Bagnato A Natali PG | 2004 | J Transl Med2004，2，1： | 1 |
| 8 | Mechanism of acute ischemic injury of oligodendroglia in early myelinating white matter: The importance of astrocyte injury and glutamate release显示文摘 | Scott W Robert TB Natalie A | 2004 | J Neuropathol Exp Neurol2004，63，8： | 1 |
| 9 | Ultrasound velocity and attenuation in cancel- lous bone samples from lumbar vertebra and calcaneus显示文摘 | Trebacz H Natali A | 1999 | Osteopo- ros Int1999，9，2： | 1 |
| 10 | Clustering of insulin resistance with vascular dysfunction and low-frad inflammation in type 2 diabetes 显示文摘 | Natali A Toschi E Baldeweg A | 2006 | Diabetes2006，55，： | 1 |
| 11 | AFC tracking algorithms 显示文摘 | Natali A F | 1984 | IEEE Trans Commun1984，32，： | 1 |
| 12 | Isolation of Ty1-copia putative LTR sequences and their use as a tool to analyse genetic diversity in Olea europaea显示文摘 | NATALI L GIORDANI T BUTI M CAVALLINI A | 2007 | Mol Breeding2007，19，： | 1 |
| 13 | Association of fasting glucagon and proinsulin concentrations with insulin resistance显示文摘 | Ferrannini E Muscelli E Natali A | 2007 | Diabetologia2007，50，11： | 1 |
| 14 | Control of the critical dimension with a trilayer nanoimprint lithography procedure显示文摘 | Lebib A Natali M Li S P | 2001 | Microelectronic Engineering2001，5758，： | 1 |
| 15 | Vascular effects of improving metabolic control with metformin or rosiglitazone in Type 2 diabetes显示文摘 | Natali A Baldeweg S Toschi E | 2004 | Jiabetes Care2004，27，6： | 1 |
| 16 | Prognostic factors in surgically resected N2 NSCLC : the importance of patterns of mediastinal lymph nodes metastases 显示文摘 | Casali C Stefani A Natali P | 2005 | Eur J Cardiothorac Surg2005，28，1： | 1 |
| 17 | Metabolic syndrome: at the crossroads of cardiorenal risk显示文摘 | Natali A Pucci G Boldrini B | 2009 | J Nephrol2009，22，1： | 1 |
| 18 | Simultaneous nitrification and denitrification using stored substratc (PHB)as the electron donor in an SBR 显示文摘 | Katie A Third Natalie Burner Ralf Cord-Ruwisch | 2003 | Biotechnol Bioeng2003，83，6： | 1 |
| 19 | Phylogeny of Rubinceae- Rubieae inferred from the sequence of a epDNA intergene region 显示文摘 | Manen J F Natali A Ehrendorfer F | 1994 | Plant Syst Evol1994，190，： | 1 |
| 20 | Expression of class I and class II major histocompatibility complex antigens on human hepatocytes显示文摘 | Franco A Barnaba V Natali P et ol | 1988 | Hepatology1988，8，3： | 1 |
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