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| 1 | 伊犁黄土的磁学性质及其与黄土高原对比显示文摘近20多年来黄土高原的黄土磁学性质与古气候研究取得了重要进展,极大地推动了东亚古季风演化、亚洲内陆干旱化及过去全球变化的研究,但对亚洲内陆天山地区的黄土磁学性质知之甚少.选择天山伊犁盆地黄土剖面进行了系统的磁性测量,包括磁化率、无磁滞磁化率、高低温磁化率和磁滞参数等,并与黄土高原进行了对比,开展了伊犁黄土的X射线衍射矿物学分析,初步探讨了伊犁黄土磁化率增强的机制.结果表明,伊犁黄土磁性矿物的总含量要远远低于黄土高原,但磁性矿物类型与黄土高原黄土基本类似,以磁铁矿、磁赤铁矿和赤铁矿为主,部分样品还有钛铁矿等.在磁性矿物中磁赤铁矿占的比例总体上要比黄土高原黄土低,而磁铁矿和赤铁矿占的比例比黄土高原黄土要高.磁性矿物的粒度要比黄土高原粗,以准单畴(PSD)和多畴(MD)为主.成壤作用产生的细粒超顺磁体对磁化率的贡献非常有限,粒径为PSD和MD的磁铁矿和磁赤铁矿为伊犁黄土磁化率的主要贡献者.伊犁黄土磁化率增强既有风速论模式(阿拉斯加或西伯利亚黄土成土模式),又有黄土高原超细颗粒成壤模式,但以前一种模式为主导.伊犁黄土磁化率增强除与源区的原生磁性矿物有关以外,还与当地的地形气候环境和地质背景有关.伊犁黄土磁化率增强的机制十分复杂,将磁化率应用古气候的解释时要慎重. | 宋友桂 史正涛 方小敏 NIE Junsheng NAOTO Ishikawa 强小科 王旭龙 | 2010 | 中国科学(D辑)2010，40，1： | 48 |
| 2 | Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions显示文摘AIM:To evaluate the utility of diffusion-weighted im-aging(DWI)in screening and differential diagnosis of benign and malignant focal hepatic lesions.METHODS:Magnetic resonance imaging(MRI)ex-aminations were performed using the Signa Excite Xl Twin Speed 1.5T system(GE Healthcare,Milwaukee,WI,USA).Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas(HCC),four cholangiocarcinomas,34 metastatic liver cancers,10 hemangiomas,and eight cysts] between April 2004 and August 2008 were retrospectively evaluated.Visu-alization of lesions,relative contrast ratio(RCR),and apparent diffusion coefficient(ADC)were compared between benign and malignant lesions on DWI.Su-perparamagnetic iron oxide(SPIO)was administered to 59 patients,and RCR was compared pre-and post-administration.RESULTS:DWI showed higher contrast between ma-lignant lesions(especially in multiple small metastatic cancers)and surrounding liver parenchyma than did contrast-enhanced computed tomography.ADCs(mean ± SD × 10-3 mm2/s)were signif icantly lower(P < 0.05)in malignant lesions(HCC:1.31 ± 0.28 and liver me-tastasis:1.11 ± 0.22)and were signifi cantly higher in benign lesions(hemangioma:1.84 ± 0.37 and cyst:2.61 ± 0.45)than in the surrounding hepatic tissues.RCR between malignant lesions and surrounding he-patic tissues signifi cantly improved after SPIO adminis-tration,but RCRs in benign lesions were not improved.CONCLUSION:DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for dif-ferential diagnosis. | Naoto Koike Akihiro Cho Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya Yuji Ohshima Nobuhiro Ohkohchi | 2009 | World Journal of Gastroenterology2009，15，46： | 38 |
| 3 | Endoscopic diagnosis of sessile serrated adenoma/polyp with and without dysplasia/carcinoma显示文摘Sessile serrated adenoma/polyps(SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a Cp G island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potentials. Detecting serrated lesions, including SSA/Ps with and without dysplasia/carcinoma, is critical, but SSA/Ps can be difficult to detect, are inconsistently identified by endoscopists and pathologists, and are often incompletely resected. Therefore, SSA/Ps are considered to be major contributors to 'interval cancers'. If colonoscopists can identify the specific endoscopic characteristics of SSA/Ps, their detection and the effectiveness of colonoscopy may improve. Here, the endoscopic features of SSA/Ps with and without dysplasia/carcinoma, including the characteristics determined using magnifying endoscopy, are reviewed in the context of previous reports. Endoscopically, these subtle polyps are like hyperplastic polyps, because they are slightly elevated and pale. Unlike hyperplastic polyps, SSA/Ps are usually larger than 5 mm, frequently covered by a thin layer called the ‘‘mucus cap'', and are more commonly located in the proximal colon. Magnifying narrow-band imaging findings, which include dark spots inside the crypts and varicose microvascular vessels, in addition to the type II-open pit patterns detected using magnifying chromoendoscopy, effectively differentiate SSA/Ps from hyperplastic polyps. The lesions' endoscopic characteristics, which include their(semi)pedunculated morphologies, double elevations, central depressions, and reddishness, and the use of magnifying endoscopy, might help to detect dysplasia/carcinoma within SSA/Ps. Greater awareness may promote further research into improving the detection, identification, and complete resection rates of SSA/Ps with and without dysplasia/carcinoma and reduce the interval cancer rates. | Takashi Murakami Naoto Sakamoto Akihito Nagahara | 2018 | World Journal of Gastroenterology2018，24，29： | 25 |
| 4 | Molecular biology and the diagnosis and treatment of liver diseases显示文摘MolecularbiologyandthediagnosisandtreatmentofliverdiseasesHowardJ.Worman,FengLin,NaotoMamiyaandPaulJ.MustacchiaSubjectheading... | Howard J. Worman, Feng Lin, Naoto Mamiya and Paul J. Mustacchia | 1998 | World Journal of Gastroenterology1998，4，3： | 24 |
| 5 | MRCP and MRI findings in 9 patients with autoimmune pancreatitis显示文摘瞄准:为了评估磁性的回声 cholangiopancreatography (MRCP ) ,与磁性的回声(先生) 一起的调查结果在自体免疫的胰腺炎(AIP ) 想象病人。方法:有 AIP 的九个病人经历了 MRI, MRCP,内视镜后退 cholangiopancreatography (ERCP ) ,计算断层摄影术,和 ultrasonography。在类固醇治疗前后拿的 MRCP 和先生图象被考察并且与另外的成像形式相比。AIP 盒子的 MRCP 调查结果与有胰的头的癌的 10 个盒子的那些相比。结果:在 MRCP 上,在 ERCP 上注意的主要的胰腺的管的缩小的部分没被设想,当主要的胰腺的管的非包含的片断被设想时。近似的主要的胰腺的管的在上游的膨胀的度比在胰腺的癌的情况下看温和。更低的胆汁管的狭窄或阻塞在 8 个病人被检测。先生图象在 T1 加权的先生图象上与减少的信号紧张显示出胰的增大, T2 加权的先生图象上的增加的信号紧张,并且,在 3 个病人,低亚硫酸钠强烈像囊的边界。在类固醇治疗以后,以前没设想主要的胰腺的管的部分被看见,与胆汁管狭窄的改进一起。胰腺的增大减少了,并且 T1 加权、 T2 加权的先生图象上的反常信号紧张成为了 isointense。结论:MRCP 不能区分从与胰腺的癌看见的主要的胰腺的管的狭窄与 AIP 看见的主要的胰腺的管的不规则的变窄。然而,与在 T1 加权、 T2 加权的先生图象上显示出反常信号紧张的胰腺的增大的先生成像一起的 MRCP 调查结果在支持 AIP 的诊断是有用的。 | Terumi Kamisawa Pong-Yui Chen Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto Noriko Kamata | 2006 | World Journal of Gastroenterology2006，12，18： | 23 |
| 6 | Daily low-intensity pulsed ultrasound-mediated osteogenic differentiation in rat osteoblasts显示文摘有很少研究,调查每天提供的机械刺激的效果低紧张的搏动的超声(LIPUS ) 处理。LIPUS 被知道加速骨头矿化作用和新生;然而,精确细胞的机制是不清楚的。我们的目的是决定 LIPUS 处理怎么每天在造骨细胞影响了房间生存能力,碱的磷酸酶活动,成骨相关的基因表示,和使矿物化的小瘤形成。典型 osteoblastic 房间线 ROS 17/2.8 房间在 LIPUS 刺激的缺席或存在是有教养的。每日的 LIPUS 处理(1.5 MHz;20 min ) 在 30 mW/cm2 的紧张被管理 14 天。成骨相关的基因的表示用西方的弄污的分析在使用即时聚合酶链反应的 mRNA 层次并且在蛋白质层次被检验。LIPUS 刺激没影响房间生存能力的率。碱的磷酸酶活动与每日的 LIPUS 刺激在 10 天文化以后被增加。LIPUS 显著地增加了编码 Runx2, Msx2, Dlx5, osterix,骨头 sialoprotein,和骨头的 mRNAs 的表示形态基因的 protein-2,而它显著地减少了编码抄写因素 AJ18 的 mRNA 的表示。使矿物化的小瘤形成显著地在白天 14 LIPUS 刺激上被增加。LIPUS 刺激直接影响了 osteogenic 房间,导致使矿物化的小瘤形成。LIPUS 是可能的在牙槽的骨头在造骨细胞的关键功能的活动有基本影响。 | Akito Suzuki Tadahiro Takayama Naoto Suzuki Michitomo Sato Takeshi Fukuda Koichi Ito | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 23 |
| 7 | Loess magnetic properties in the Ili Basin and their correlation with the Chinese Loess Plateau显示文摘Over the past two decades, magnetoclimatological studies of loess-paleosol sequences in the Chinese Loess Plateau (CLP) have made outstanding achievements, which greatly promote the understanding of East Asian paleomonsoon evolution, inland aridification of Asia, and past global climate changes. Loess magnetic properties of the CLP have been well studied. In contrast, loess magnetic properties from outside the CLP in China have not been fully understood. We have little knowledge about the magnetic properties of loess in the Ili Basin, an intermontane depression of the Tianshan (or Tien Shan) Mountains. Here, we present the results of rock magnetic measurements of the Ili loess including mass magnetic susceptibility (χ) and anhysteretic remanent magnetization (ARM), high/low temperature dependence of susceptibility (TDS) and hysteresis, as well as X-ray diffraction (XRD) for mineral analysis. Based on the comparison with loess-paleosol sequences in the CLP (hereafter referred to as the Chinese loess), we discuss the possible magnetic susceptibility enhancement mechanism of the Ili loess. The results show that 1) the total magnetic mineral concentration of the Ili loess is far lower than that of the Chinese loess, though they have similar magnetic mineral compositions. The ferrimagnetic minerals in the Ili loess are magnetite and maghemite, and the antiferromagnetic mineral is hematite; XRD analysis also identifies the presence of ilmenite. The ratio of maghemite is lower in the Ili loess than in the Chinese loess, but the ratios of magnetite and hematite are higher in the Ili loess than in the Chinese loess. 2) The granularity of magnetic minerals in the Ili loess, dominated by pseudo-single domain (PSD) and multi-domain (MD) grains, is generally much coarser than that of the Chinese loess. Ultrafine pedogenically-produced magnetic grains have a very limited contribution to the susceptibility enhancement. Rather, PSD and MD particles of magnetite and maghemite are the main contributors to the enhancement of susceptibility in the Ili loess. 3) The susceptibility enhancement mechanism for the Ili loess is complicated and superimposes both a wind velocity/vigor model (Alaskan or Siberian model) and the in situ ultrafine grain pedogenic model; the former might play an important role in the Ili loess. 4) Magnetic susceptibility enhancements of the Ili loess are related not only to the eolian input of the source area, but also to the local climate, landform, and geological background. Therefore, great care should be taken when reconstructing paleoclimate using magnetic susceptibility data from the Ili loess. | NAOTO Ishikawa | 2010 | Science China Earth Sciences2010，53，3： | 21 |
| 8 | Strategy to differentiate autoimmune pancreatitis from pancreas cancer显示文摘Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic 'IgG4-related sclerosing disease'. Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. Findings suggesting AIP rather than pancreatic cancer include:fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed en- hancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection. | Kensuke Takuma Terumi Kamisawa Rajesh Gopalakrishna Seiichi Hara Taku Tabata Yoshihiko Inaba Naoto Egawa Yoshinori Igarashi | 2012 | World Journal of Gastroenterology2012，18，10： | 20 |
| 9 | Sentinel lymph node navigation surgery for early stage gastric cancer显示文摘We attempted to evaluate the history of sentinel node navigation surgery(SNNS),technical aspects,tracers,and clinical applications of SNNS using Infrared Ray Electronic Endoscopes(IREE)combined with Indocyanine Green(ICG).The sentinel lymph node(SLN)is defined as a first lymph node(LN)which receives cancer cells from a primary tumor.Reports on clinical application of SNNS for gastric cancers started to appear since early 2000s.Two prospective multicenter trials of SNNS for gastric cancer have also been accomplished in Japan.Kitagawa et al reported that the endoscopic dual(dye and radioisotope)tracer method for SN biopsy was confirmed acceptable and effective when applied to the early-stage gastric cancer(EGC).We have previously reported the usefulness of SNNS in gastrointestinal cancer using ICG as a tracer,combined with IREE(Olympus Optical,Tokyo,Japan)to detect SLN.LN metastasis rate of EGC is low.Hence,clinical application of SNNS for EGC might lead us to avoid unnecessary LN dissection,which could preserve the patient’s quality of life after operation.The most ideal method of SNNS should allow secure and accurate detection of SLN,and real time observation of lymphatic flow during operation. | Norio Mitsumori Hiroshi Nimura Naoto Takahashi Masahiko Kawamura Hiroaki Aoki Atsuo Shida Nobuo Omura Katsuhiko Yanaga | 2014 | World Journal of Gastroenterology2014，20，19： | 15 |
| 10 | Relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes显示文摘Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide.The metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic liver disease(ALD).Antioxidant phytochemicals,such as polyphenols,regulate the expression of ALD-associated proteins and peptides,namely,catalase,superoxide dismutase,glutathione,glutathione peroxidase,and glutathione reductase.These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1--NF--E2--related factor--2 pathway and antioxidant responsive elements.Furthermore,these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines.These phenomena are likely induced via the regulation of mitogen--activating protein kinase(MAPK)pathways by plant antioxidants,similar to preconditioning in ischemia-reperfusion models.Although the relationship between plant antioxidants and ALD has not been adequately investigated,plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway. | Kyu-Ho Han Naoto Hashimoto Michihiro Fukushima | 2016 | World Journal of Gastroenterology2016，22，1： | 14 |
| 11 | Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer显示文摘Accurate prediction of lymph node(LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer(EGC). However,consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search,we identified several independent variables associated with LN metastasis in EGC,which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand,even if we use these promising parameters,we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN(SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review,we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition,we evaluated the history of sentinel node navigation surgery and the usefulness for EGC. | Atsuo Shida Norio Mitsumori Hiroshi Nimura Yuta Takano Taizou Iwasaki Muneharu Fujisaki Naoto Takahashi Katsuhiko Yanaga | 2016 | World Journal of Gastroenterology2016，22，33： | 13 |
| 12 | Usefulness of biopsying the major duodenal papilla to diagnose autoimmune pancreatitis:A prospective study using IgG4-immunostaining显示文摘瞄准:检验组织学并且免疫从自体免疫的胰腺炎(AIP ) 的主要十二指肠的乳头状的小突起拿的活体检视标本的组织化学的调查结果病人们。方法:在有 AIP 的 3 个病人并且 5 个控制病人的 resected 胰的主要十二指肠的乳头状的小突起[胰腺的癌(n = 3 ) 并且长期的含酒精的胰腺炎(n = 2 )] 免疫用 anti-CD4-T 房间, CD8-T 房间和 IgG4 抗体被染色。与怀疑的视神经乳头炎与 AIP 和 5 个控制病人从 2 个病人的主要十二指肠的乳头状的小突起拿的钳活体检视标本有希望地在组织化学地检验的十二指肠镜检查和免疫期间被拿。结果:包括许多 CD4 积极或 CD8 积极的 T 淋巴细胞和 IgG4 积极的血浆房间(>or=10/HPF ) 的中等或严重的 lymphoplasmacytic 渗入,与 AIP 在所有 3 个病人的主要十二指肠的乳头状的小突起被观察。一样的调查结果也在与 AIP 从 2 个病人的主要十二指肠的乳头状的小突起拿的活体检视标本,但是在控制被检测,仅仅有一些(<or=3/HPF ) 渗入主要十二指肠的乳头状的小突起的 IgG4 积极的血浆房间。结论:IgG4 积极的血浆房间的丰富的渗入明确地与 AIP 在病人的主要十二指肠的乳头状的小突起被检测。尽管这是初步的研究,从主要十二指肠的乳头状的小突起拿的活体检视标本的 IgG4-immunostaining 可以支持 AIP 的诊断。 | Terumi Kamisawa Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto | 2006 | World Journal of Gastroenterology2006，12，13： | 13 |
| 13 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 14 | Diagnosis and clinical implications of pancreatobiliary reflux显示文摘Oddi 的括约肌在远侧的结束被定位胰腺并且胆汁管并且调整胆汁和胰液的流出。一条普通隧道能那么长连接胰腺并且胆汁管在十二指肠的墙外面被定位,,发生在 pancreaticobiliary maljunction (PBM ) ;在如此的情况中,括约肌行动机能上地不影响连接。因为在胰腺的管以内的水疗院压力通常比在胆汁管大,胰液经常倒流进在 PBM 的胆汁的管(pancreatobiliary 倒流) ,导致致癌物在胆道的非位的条件。Pancreatobiliary 倒流能经由次要的十二指肠的乳头状的小突起在胆汁,刺激分泌素的动态磁性的回声 cholangiopancreatography,和 pancreatography 从提高的淀粉酶水平被诊断。最近,没有 PBM, pancreatobiliary 倒流能发生在个人,变得明显。没有 PBM, Pancreatobiliary 倒流可能甚至在一些个人与胆汁的致癌作用有关。因为很少全身的研究与正常 pancreaticobiliary 连接在个人关于 pancreatobiliary 倒流的临床的关联和含意存在,包括适当管理的进一步未来的临床的研究应该被执行。 | Terumi Kamisawa Hajime Anjiki Naoto Egawa Masanao Kurata Goro Honda Kouji Tsuruta | 2008 | World Journal of Gastroenterology2008，14，43： | 12 |
| 15 | Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis显示文摘AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis.METHODS: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/ HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%,respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION: The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis. | Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi | 2012 | World Journal of Hepatology2012，4，1： | 10 |
| 16 | Pancreatic cancer with a high serum IgG4 concentration显示文摘Differentiation between autoimmune pancreatitis and pancreatic cancer is sometimes difficult. It has been reported that serum IgG4 concentrations are significantly elevated and particularly high (>135 mg/dL) in autoimmune pancreatitis. Measurement of serum IgG4 has become a useful tool for differentiating between autoimmune pancreatitis and pancreatic cancer. However, we present a 74-year-old female with a markedly elevated serum IgG4 (433 mg/dL) who underwent pancreaticoduodenectomy for pancreatic cancer. Elevated serum IgG4 levels continued after the resection. On histology, adenocarcinoma of the pancreas accompanied with moderate lymphoplasmacytic infiltration infiltrated the lower bile duct and duodenum, but there were no findings of autoimmune pancreatitis. Although a small metastasis was detected in one parapancreatic lymph node, regional lymph nodes were swollen. Abundant IgG4-positive plasma cells infiltrated the cancerous areas of the pancreas, but only a few IgG4-positive plasma cells were detected in the noncancerous areas. Pancreatic cancer cells were not immunoreactive for IgG4. An abundant infiltration of IgG4-positive plasma cells was detected in the swollen regional lymph nodes and in the duodenal mucosa. We believe that the serum IgG4 level was elevated in this patient with pancreatic cancer as the result of an IgG4-related systemic disease that had no clinical manifestations other than lymphadenopathy. | Terumi Kamisawa Pong Yui Chen Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto Tsunekazu Hishima | 2006 | World Journal of Gastroenterology2006，12，38： | 10 |
| 17 | Ca_(1−x)Li_(x)Al_(1−x)Si_(1+x)N_(3):Eu^(2+) solid solutions as broadband,color-tunable and thermally robust red phosphors for superior color rendition white light-emitting diodes显示文摘Color rendition,luminous efficacy and reliability are three key technical parameters for white light-emitting diodes(wLEDs)that are dominantly determined by down-conversion phosphors.However,there is usually an inevitable trade-off between color rendition and luminescence efficacy because the spectrum of red phosphor(that is,spectral broadness and position)cannot satisfy them simultaneously.In this work,we report a very promising red phosphor that can minimize the aforementioned trade-off via structure and band-gap engineering,achieved by introducing isostructural LiSi_(2)N_(3) into CaAlSiN_(3):Eu^(2+).The solid solution phosphors show both substantial spectra broadening(88→117 nm)and blueshift(652→642 nm),along with a significant improvement in thermal quenching(only a 6%reduction at 150℃),which are strongly associated with electronic and crystal structure evolutions.The broadband and robust red phosphor thus enables fabrication of super-high color rendering wLEDs(Ra=95 and R9=96)concurrently with the maintenance of a high-luminous efficacy(101 lm W^(−1)),validating its superiority in highperformance solid state lightings over currently used red phosphors. | Le Wang Rong-Jun Xie Yuanqiang Li Xiaojun Wang Chong-Geng Ma Dong Luo Takashi Takeda Yi-Ting Tsai Ru-Shi Liu Naoto Hirosaki | 2016 | Light(Science & Applications)2016，5，1： | 9 |
| 18 | Sclerosing cholangitis associated with autoimmune pancreatitis differs from primary sclerosing cholangitis显示文摘AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characteristics of 34 patients with sclerosing cholangitis(SC) associated with AIP were compared with those of 4 patients with PSC.RESULTS:SC with AIP occurred predominantly in el-derly men.Obstructive jaundice was the most frequent initial symptom in SC with AIP.Only SC patients with AIP had elevated serum IgG4 levels,and sclerosing diseases were more frequent in these patients.SC pa-tients with AIP responded well to steroid therapy.Seg-mental stenosis of the lower bile duct was observed only in SC patients with AIP,but a beaded and pruned-tree appearance was detected only in PSC patients.Dense infi ltration of IgG4-positive plasma cells was de-tected in the bile duct wall and the periportal area,as well as in the pancreas,of SC patients with AIP.CONCLUSION:SC with AIP is distinctly different from PSC.The two diseases can be discriminated based on cholangiopancreatographic findings and serum IgG4 levels. | Terumi Kamisawa Kensuke Takuma Hajime Anjiki Naoto Egawa Masanao Kurata Goro Honda Kouji Tsuruta | 2009 | World Journal of Gastroenterology2009，15，19： | 9 |
| 19 | Magnetostratigraphy of Late Tertiary sediments from the Chinese Loess Plateau and its paleoclimatic significance显示文摘The Late Tertiary red clay/bed sediments underlying the Quaternary loess-paleosol in the Chinese Loess Plateau possesses high-resolution paleoclimatic changes related to the uplift of the Tibetan Plateau. Magnetostratigra-phy and susceptibility measurements are discussed in this paper. The paleomagnetic results show that the red clay/bed began to accumulate at about 8.1 Ma, which represents the oldest Late Tertiary deposit continuously in the central Loess Plateau. The magnetic susceptibility curves show stepwise increases since the initiation of red clay, superimposed on several peaks. Moreover, the magnetic susceptibility increased abruptly since 3.8 Ma, which probably indicates the inception of the modern East Asia monsoon system. Between 3.8 and 2.6 Ma, the stepwise increases of susceptibility may imply progressively intensified East Asia summer monsoon activity related with the stepwise uplift process of the Tibetan Plateau. | SONG Yougui FANG Xiaomin MASAYUKI Torii NAOTO Ishikawa LI Jijun AN Zhisheng | 2001 | Chinese Science Bulletin2001，46，S1： | 9 |
| 20 | Estimation of herbage intake and digestibility of grazing sheep in Zhenglan Banner of Inner Mongolia by using n-alkanes显示文摘To reveal the seasonal dynamics of herbage intake, diet composition and digestibility and clarify the relationship of those with herbage nutrient and botanical composition of grazing sheep in Zhenglan Banner of Inner Mongolia, the n-alkane technique was used to test in sheep grazed during June, August and December. The results showed that the sheep mainly ate Fringed sagebrush, Stipa krylovii and Carex in proportions of 33.5,17.9 and 21.2%, respectively, in spring. In summer, the sheep consumed cleistogenes,Potentilla tanacetifolia, Thyme, etc; the intake of Fringed sagebrush, Carex and Stipa declined. In winter,Fringed sagebrush accounted for 50.1% of herbage intake, and the intakes of Cleistogenes and Stipa krylovii increased to 15.3 and 18.4%, respectively. Herbage intake by the sheep in spring was 1.8 kg DM/d, and digestibility was 71.4%. Herbage intake and digestibility decreased slightly to 1.7 kg DM/d and 68.4%during the summer, respectively and decreased significantly to 1.2 kg DM/d and 36.4% in winter. There were significant correlations between diet composition and CP content in winter, diet composition and botanical composition in summer. A highly positive correlation between herbage intake and digestibility was observed in grazing sheep. | Changqing Li Alatengdalai Shuyuan Xue Atsushi Tajima Naoto Ishikawa | 2015 | Animal Nutrition2015，，4： | 9 |
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