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| 1 | Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?显示文摘In immunoglobulin G4(IgG4)-related disease(RD),organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs.Although infiltration of many IgG4-positive plasma cells is detected in the gastric and colonic mucosa and major duodenal papilla of patients with autoimmune pancreatitis,it cannot be diagnosed as a gastrointestinal lesion involved in IgG4-RD,because none of the following is observed in these lesions:a mass-like formation;dense fibrosis;or obliterative phlebitis.Based on our review of the literature,there appear to be two types of IgG4-related gastrointestinal disease.One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach,consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells,which usually show submucosal spreading.The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach,colon,and major duodenal papilla,showing polypoid or mass-like lesions.Most solitary IgG4-related gastrointestinal lesions that are not associated with other IgG4-RD appear to be difficult to diagnose.It is of utmost importance to rule out malignancy.However,these lesions may respond to steroid therapy.To avoid unnecessary resection,IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. | Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Yuka Endo Go Kuwata Koichi Koizumi Tooru Shimosegawa Kazuichi Okazaki Tsutomu Chiba | 2013 | World Journal of Gastroenterology2013,19,35: | 12 |
| 2 | 原发性硬化性胆管炎诊断及治疗指南(2021)显示文摘2015年我国第一个原发性硬化性胆管炎(PSC)的专家共识颁布。近年来PSC的临床研究提供了PSC新的研究数据和资料。为此,中华医学会肝病学分会自身免疫性肝病学组组织专家组对近年来的文献证据进行了评估,制定了本指南。本指南共有PSC推荐意见21条。为了利于鉴别PSC和IgG4相关硬化性胆管炎(IgG4-SC),也附有IgG4-SC的10条推荐意见。本指南的目的是为临床PSC和IgG4-SC的诊治提供参考和指导。 | 中华医学会肝病学分会 韩英 郭长存 时永全 尚玉龙 董加强 崔丽娜 郭冠亚 郑林华 尤红 陆伦根 马雄 南月敏 徐小元 段钟平 魏来 庄辉 | 2021 | 中华内科杂志2021,60,12: | 11 |
| 3 | Autoimmune pancreatitis versus pancreaticcancer: a comprehensive review withemphasis on differential diagnosis显示文摘BACKGROUND: Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis with a discrete pathophysiology occasional diagnostic radiological findings, and characteristic histological features. Its etiology and pathogenesis are still under investigation, especially during the last decade Another aspect of interest is the attempt to establish specific criteria for the differential diagnosis between autoimmune pancreatitis and pancreatic cancer, entities that are frequently indistinguishable. DATA SOURCES: An extensive search of the PubMed database was performed with emphasis on articles about the differential diagnosis between autoimmune pancreatitis and pancreatic cancer up to the present. RESULTS: The most interesting outcome of recent research is the theory that autoimmune pancreatitis and its various extra-pancreatic manifestations represent a systemic fibro inflammatory process called IgG4-related systemic disease The diagnostic criteria proposed by the Japanese Pancreatic Society, the more expanded HISORt criteria, the new definitions of histological types, and the new guidelines of the International Association of Pancreatology help to establish the diagnosis of the disease types. CONCLUSION: The valuable help of the proposed criteria for the differential diagnosis between autoimmune pancreatitis and pancreatic cancer may lead to avoidance of pointless surgical treatments and increased patient morbidity. | Kyriakos Psarras Minas E Baltatzis Efstathios T Pavlidis Miltiadis A Lalountas Theodoros E Pavlidis Athanasios K Sakantamis | 2011 | Hepatobiliary & Pancreatic Diseases International2011,10,5: | 9 |
| 4 | 自身免疫性胰腺炎7例临床误诊分析显示文摘 | 王红 梁军 张华勇 孙凌云 | 2010 | 江苏医药2010,36,6: | 7 |
| 5 | IgG4检测在自身免疫性胰腺炎诊治中的应用进展显示文摘自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是与自身免疫损伤相关的慢性胰腺炎症,作为一个全新的临床疾病独立分型,受到越来越多的关注。争取早期诊断与治疗、预测复发与判断预后及提高诊治水平已成为近期基础研究和临床医师所关注的焦点[1]。 | 吴康 沈茜 | 2011 | 检验医学2011,26,2: | 7 |
| 6 | 自身免疫性胰腺炎的临床和病理特征显示文摘自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是一种罕见的具有独特的临床和组织形态学特点、以自身免疫性为病因的慢性胰腺炎。由于AIP患者的其他器官或部位常有相似的组织学改变,且都有免疫球蛋白G4(immunoglobin G4,IgG4)阳性浆细胞组织内浸润增多,以及对类固醇激素治疗有效,由此提出了一种全新的与IgG4相关的全身性疾病(IgG4-associated systemic disease,ISD)的临床病理概念。本文主要阐述AIP及ISD的临床表现、诊断标准、病理学特点及其相关的胰腺外器官表现。 | 张赫男 孙丽梅 | 2011 | 国际病理科学与临床杂志2011,31,4: | 6 |
| 7 | Endoscopic approach for diagnosing autoimmune pancreatitis显示文摘It is of utmost importance to differentiate autoimmune pancreatitis(AIP) from pancreatic cancer(PC).Segmental AIP cases are sometimes difficult to differentiate from PC.On endoscopic retrograde cholangio pancreatography,long or skipped irregular narrowing of the main pancreatic duct(MPD),less upstream dilatation of the distal MPD,side branches derived from the narrowed portion of the MPD,absence of obstruction of the MPD,and stenosis of the intrahepatic bile duct suggest AIP rather than PC.Abundant infiltration of IgG4-positive plasma cells is frequently and rather specifically detected in the major duodenal papilla of AIP patients.IgG4-immunostaining of biopsy specimens obtained from the major duodenal papilla is useful for supporting a diagnosis of AIP with pancreatic head involvement.On endoscopic ultrasonography(EUS),hyperechoic spots in the hypoechoic mass and the duct-penetrating sign suggest AIP rather than PC.EUS and intraductal ultrasonography sometimes show wall thickening of the common bile duct even in the segment in which abnormalities are not clearly observed with cholangiography in AIP patients.EUS-guided fine needle aspiration,especially EUS-guided Tru-Cut biopsy,is useful to diagnose AIP,as well as to exclude PC. | Terumi Kamisawa Hajime Anjiki Kensuku Takuma Naoto Egawa Takao Itoi Fumihide Itokawa | 2010 | World Journal of Gastrointestinal Endoscopy2010,2,1: | 6 |
| 8 | Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients显示文摘 | Guo Limei Huang Yonghui Wang Tianli Shi Xueying Chang Hong Yao Wei Huang Xuebiao | 2014 | Chinese Medical Journal2014,,23: | 5 |
| 9 | 自身免疫性胰腺炎二例报道并文献复习显示文摘自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是自身免疫介导的、以梗阻性黄疸、高血清γ球蛋白血症及IgG升高、胰腺弥漫增大、纤维化及导管不规则狭窄为临床特征的慢性胰腺炎症。1961年Sarles等首次报道本病,现已将它作为CP的独立分型存在,但发病机制尚不清楚。我院于2006年收治合并有其他免疫性疾病的AIP患者2例,现报道如下。 | 刘兆云 张春燕 杨云生 李闻 | 2007 | 胰腺病学2007,7,5: | 5 |
| 10 | 原发性硬化性胆管炎诊断及治疗指南(2021)显示文摘2015年我国第一个原发性硬化性胆管炎(PSC)的专家共识颁布。近年来PSC的临床研究提供了PSC新的研究数据和资料。为此,中华医学会肝病学分会自身免疫性肝病学组组织专家组对近年来的文献证据进行了评估,制定了本指南。本指南共有PSC推荐意见21条。为了利于鉴别PSC和IgG4相关硬化性胆管炎(IgG4-SC),也附有IgG4-SC的10条推荐意见。本指南的目的是为临床PSC和IgG4-SC的诊治提供参考和指导。 | 中华医学会肝病学分会 韩英 郭长存 时永全 尚玉龙 董加强 崔丽娜 郭冠亚 郑林华 尤红 陆伦根 马雄 南月敏 徐小元 段钟平 魏来 贾继东 庄辉 | 2022 | 中华肝脏病杂志2022,30,2: | 4 |
| 11 | IgG4检测在自身免疫性胰腺炎诊治中的应用进展显示文摘综述了IgG4在自身免疫性胰腺炎(Autoimmune Pancreatitis,AIP)的诊断和治疗中的临床应用进展。资料显示AIP患者血清IgG4水平明显升高,相应炎症组织中有IgG4+浆细胞浸润,治疗过程中血清IgG4水平下降及组织中大量IgG4+浆细胞浸润减少则治疗有效。治疗后血清IgG4水平再度升高且组织中IgG4+浆细胞再度浸润则预示复发且预后不良。研究认为,IgG4可作为AIP早期诊断的检测指标之一,动态监测血清IgG4水平及组织中IgG4+浆细胞浸润程度对AIP的疗效监测、复发预测及预后判断具有指导意义。 | 李玉明 | 2011 | 中国医学创新2011,8,20: | 2 |
| 12 | 自身免疫性胰腺炎病例分析并文献复习显示文摘目的分析自身免疫性胰腺炎(autoimmune pancreatitis,AIP)的临床特点及诊疗措施。方法回顾分析1例AIP患者的临床表现、实验室检查、影像学检查、治疗及随访情况。结果本病例结合临床表现,血清IgG、γ球蛋白增高,正电子发射体层摄影术/计算机体层摄影术(PET/CT)、磁共振胰胆管造影术(magnetic resonance chdangipancreatography,MRCP)等影像学检查表现为胰腺弥漫性肿大,呈腊肠样改变,胆总管(胰腺段)及胰管狭窄等证实为AIP,给予激素治疗有效,目前仍在随访中。结论 AIP患者的实验室、影像及病理学检查具有特征性改变,是诊断AIP的重要手段,临床应提高对此类疾病的认识。 | 杨璐 曹悦鞍 彭朝胜 张文洛 夏菁 谢文秀 | 2011 | 海军总医院学报2011,24,3: | 2 |
| 13 | 自身免疫性胰腺炎的内镜诊断显示文摘自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是少见的胰腺良性疾病。作为独立疾病的命名,AIP于1995年由Yoshida等提出,且描述本病的特征为胰腺实质内大量淋巴细胞浆细胞的浸润,伴有胰腺内外分泌功能的障碍。临床表现为体重下降、黄疸以及慢性非特异性腹痛,腹痛程度较轻。 | 孟欣颖 | 2012 | 中华胰腺病杂志2012,12,2: | 2 |