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| 1 | Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study显示文摘AIM: Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH<4) of more than 5% and mild esophagitis (SavaryMiller grades Ⅰ, Ⅱ) proven by endoscopy. Ambulatory 24-h pH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day (t.i.d.) for 30 d in random order, using an open label method.For evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after treatment.RESULTS: Total symptom score was significantly decreased after treatment in 150- or 300-mg group. Itopride 300mg was significantly effective than 150 mg on decreasing the total per cent time with pH<4, total time with pH<4and DeMeester score. No serious adverse effects were observed with administration of itopride in both groups.CONCLUSION: Itopride 100 mg t.i.d, is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease. | Yong Sung Kim Tae Hyeon Kim Chang Soo Choi Young Woo Shon Sang Wook Kim Geom Seog Seo Yong Ho Nah Myung Gyu Choi Suck Chei Choi | 2005 | World Journal of Gastroenterology2005，11，27： | 15 |
| 2 | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin显示文摘 | Dong-soon IM Seung-yeol NAH | 2013 | Acta Pharmacologica Sinica2013，34，11： | 11 |
| 3 | Scalable synthesis of nanoporous silicon microparticles for highly cyclable lithium-ion batteries显示文摘Nanoporous silicon is a promising anode material for high energy density batteries due to its high cycling stability and high tap density compared to other nanostructured anode materials.However,the high cost of synthesis and low yield of nanoporous silicon limit its practical application.Here,we develop a scalable,low-cost top-down process of controlled oxidation of Mg2Si in the air,followed by HCl removal of MgO to generate nanoporous silicon without the use of HF.By controlling the synthesis conditions,the oxygen content,grain size and yield of the porous silicon are simultaneously optimized from commercial standpoints.In situ environmental transmission electron microscopy reveals the reaction mechanism;the Mg2Si microparticle reacts with O2 to form MgO and Si,while preventing SiO2 formation.Owing to the low oxygen content and microscale secondary structure,the nanoporous silicon delivers a higher initial reversible capacity and initial Coulombic efficiency compared to commercial Si nanoparticles(3,033 mAh/g vs.2,418 mAh/g,84.3%vs.73.1%).Synthesis is highly scalable,and a yield of 90.4%is achieved for the porous Si nanostructure with the capability to make an excess of 10 g per batch.Our synthetic nanoporous silicon is promising for practical applications in next generation lithium-ion batteries. | Jiangyan Wang William Huang Yong Seok Kim You Kyeong Jeong Sang Cheol Kim Jeffrey Heo Hiang Kwee Lee Bofei Liu Jaehou Nah Yi Cui | 2020 | Nano Research2020，13，6： | 9 |
| 4 | An Epigenetic Role for Disrupted Paternal Gene Expression in Postzygotic Seed Abortion in Arabidopsis Interspecific Hybrids显示文摘种间的混血儿经常增加杂合现象和混合活力的层次,而是一些种间的混合种子立即在授精以后被放弃。在这 postzygotic 种子流产后面的机制糟糕被理解。这里,我们在在在 Arabidopsis thaliana (关口, Ler,或 C24 ) 和 Arabidopsis arenosa 之间的三个 F1 种间的十字开发 siliques 和种子报导突变而产生之遗传的表示变化的染色体宽的分析。似母亲的多数表示了基因(MEG ) 而 272 父亲一般地表示的基因(木钉) 的 ∼90% 仅仅在一或二个 F1 十字被发现,在所有三个 F1 种间的十字之中被分享,在在不同十字变化的种子流产为破坏父亲的基因表示建议一个角色。与这个观点一致,在不肥沃的种间的混血儿的 12 个木钉在肥沃的 intraspecific 混血儿匹配 MEG。在种间的混血儿的木钉的这混乱与在在一位双母亲和一位 hexaploid 父亲之间的父亲过量的 interploidy 十字(2X6 ) 的基因的 upregulation 一致,导致种子流产。而且,在种间的十字的木钉的一个子集也是在 intraspecific 混血儿 met1XWT 或 meaXWT 的 upregulated,在哪个 MET1 (DNA METHYLTRANSFERASE1 ) 的异种或美狄亚, Polycomb 压抑的 Complex2gene,被用作母亲的父母。这些数据建议母亲的 epigenetic 因素和父亲的基因表示在种间的混血儿或 neo-allopolyploids 在 postzygotic 种子流产起重要作用。 | Ryan C. Kirkbride Helen Hong Yu Gyoungju Nah Changqing Zhang Xiaoli Shi Z. Jeffrey Chen | 2015 | Molecular Plant2015，8，12： | 5 |
| 5 | A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor显示文摘Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively. | Sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong Jong Hwa Lee Yang Won Nah Sung Jo Bang Jung Woo Shin Neung Hwa Park Do Ha Kim | 2007 | World Journal of Gastroenterology2007，13，24： | 4 |
| 6 | The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy显示文摘 | Alisher Eshmuratov Jong Chun Nah Nayoung Kim Hye Seung Lee Hee Eun Lee Byoung Hwan Lee Min Sik Uhm Young Soo Park Dong Ho Lee Hyun Chae Jung In Sung Song | 2010 | Digestive Diseases and Sciences2010，，5： | 2 |
| 7 | Galactosylated chitosan/ DNA nanoparticles prepared using water-soluble chitosan as a gene carrier显示文摘 | Kim T H Park I K Nah J W | 2004 | Biomaterials2004，25，3： | 1 |
| 8 | Antimicrobial activities of the ethanol extracts of capsicum fruits with different levels of pungency 显示文摘 | SOETARNO S SUKRASNO S YULI- NAH E | 1997 | JMS1997，2，2： | 1 |
| 9 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 10 | Use of a classroom response system to enhance classroom interactivity显示文摘 | Siau K Sheng H Nah F.F.H | | 0，，03： | 1 |
| 11 | Surgical repair of incarcerated inguinal hernia in children :laparoscopic or open? 显示文摘 | Nah SA Giacomello L Eaton S | 2011 | Eur J Pediatr Surg2011，21，1： | 1 |
| 12 | Therapeutic drug concentrations of teicoplanin in clinical settings显示文摘 | Nah S Y Im J H Yeo J Y | 2014 | Infect Chemother2014，46，1： | 1 |
| 13 | A trace component of ginseng that inhibits Ca2 + channels through a pertussis toxin-sensitive G protein显示文摘 | NAH S PARK H MCCLESKEY E W | 1995 | Proc Natl Aced Sci USA1995，92，19： | 1 |
| 14 | Treatment of house hold waste water using an intermittently aerated membrane bioreactor 显示文摘 | Ick - Tae Yeom Yoo - Mi Nah Kyu - Hong Ahn | 1999 | Desalination1999，124，： | 1 |
| 15 | Large-area synthesis of high-quality and uniform graphene films on copper foils显示文摘 | LI Xue-song CAI Wei-wei AN Jin-ho KIM S NAH J YANG Dong-xing P1NER R VELAMAKANNI A JUNG I TUTUC E BANERJEE S K COLOMBO L RUOFF R S | 2009 | Science2009，324，5932： | 1 |
| 16 | Mechanical Pretreatment of waste activated sludge for anaerobic digestion process显示文摘 | | 2000 | Wat Res2000，34，8： | 1 |
| 17 | TiO2-WO3 Composite Nanotubes by Alloy Anodization: Growth and Enhanced Electrochromic Properties 显示文摘 | Nah Y C Chicov A Kim D | 2008 | J Am Chem Soc2008，130，16： | 1 |
| 18 | Investigation of the mechanical properties and chemical resistance of PC/PBT/impact modifier blends 显示文摘 | LYU M Y PAE Y NAH C | 2003 | Int Polym Proc2003，18，4： | 1 |
| 19 | Acutte abdominal pain in systemic lupus erythematosus:factors eontributing to recurrence of lupus enteritis显示文摘 | KIM YG HAHK NAH SS | 2006 | Ann Rheum Dis2006，65，11： | 1 |
| 20 | Treatment of household wastewater using an intermittently aerated membrane bio-reactor 显示文摘 | Yeom I T Nah Y M Ahn K H | 1999 | Desalination1999，124，13： | 1 |
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