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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | Highprevalence of sick building syndrome in a new air-conditioned building in Italy显示文摘 | Abbritti G Muzi G Accattoli MP | 1992 | Arch Environ Health1992，47，1： | 3 |
| 3 | Authenticating GNSS civilian signals:a survey显示文摘Civilian services of Global Navigation Satellite System are threatened by spoofng attacks since it is hard to determine the authenticity of a navigation signal with a detailed structure open to the public.Signal authentication efectively protects the security of the signal by attaching unforgeable information to one or several elements of the signal.Receivers can verify the authenticity of the signal by extracting and validating this information.Developing good signal authentication schemes requires understanding possible spoofng modes,signal element specialty,and performance evaluation methods.This paper is an overview of navigation signal authentication,where the theories and reported approaches are described in detail.A design/performance matrix that demonstrates the advantages and defects of the signal element and its authentication design is summarized.Recommendations are proposed to improve the robustness,security,efciency,and implementation hardness for future designs of navigation signal authentication. | Muzi Yuan Xiaomei Tang Gang Ou | 2023 | Satellite Navigation2023，4，1： | 2 |
| 4 | Reannotation of the cultivated strawberry genome and establishment of a strawberry genome database显示文摘Cultivated strawberry(Fragaria×ananassa)is an important fruit crop species whose fruits are enjoyed by many worldwide.An octoploid of hybrid origin,the complex genome of this species was recently sequenced,serving as a key reference genome for cultivated strawberry and related species of the Rosaceae family.The current annotation of the F.ananassa genome mainly relies on ab initio predictions and,to a lesser extent,transcriptome data.Here,we present the structure and functional reannotation of the F.ananassa genome based on one PacBio full-length RNA library and ninety-two Illumina RNA-Seq libraries.This improved annotation of the F.ananassa genome,v1.0.a2,comprises a total of 108,447 gene models,with 97.85%complete BUSCOs.The models of 19,174 genes were modified,360 new genes were identified,and 11,044 genes were found to have alternatively spliced isoforms.Additionally,we constructed a strawberry genome database(SGD)for strawberry gene homolog searching and annotation downloading.Finally,the transcriptome of the receptacles and achenes of F.ananassa at four developmental stages were reanalyzed and qualified,and the expression profiles of all the genes in this annotation are also provided.Together,this study provides an updated annotation of the F.ananassa genome,which will facilitate genomic analyses across the Rosaceae family and gene functional studies in cultivated strawberry. | Tianjia Liu Muzi Li Zhongchi Liu Xiaoyan Ai Yongping Li | 2021 | Horticulture Research2021，8，1： | 2 |
| 5 | Singularity spectrum of fractal signals from wavelet analysis: Extract results显示文摘 | MUZY J F BACRY E ARNEODO A | 1993 | J of Stat Phys1993，70，： | 1 |
| 6 | signal: The structure function Multifractal formalism for fractal approach versus the wavelet- transform modulus-maxima method显示文摘 | Muzy JF Bacry E Arneodo A | 1993 | Phys Rev E1993，47，： | 1 |
| 7 | But not etomidate,reduces desflurane-mediated sympathetic activation in humans显示文摘 | Lopatka CW Muzi M Ebert Propofol | 1999 | Can J Anaesth1999，，46： | 1 |
| 8 | Sympathetic responses to induction of anaesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，： | 1 |
| 9 | Cardiovascular responses to sevoflurane : a review 显示文摘 | Ebert TJ Harkin CP Muzi M | 1995 | Anesth Analg1995，81，6： | 1 |
| 10 | Fluoroquinoloneinduced tendinitis and tendon rupture in kidney transplant recipients:2 cases and a review of the literature显示文摘 | Muzi F Gravante G Tati E | | 0，，： | 1 |
| 11 | Modeling Fluctuation of Financial Time Series:From Cascade Process to Stochastic Volatility Model显示文摘 | MUZY J F DELOUR J BACRY E | 2000 | The European Physical Journal B2000，17，2： | 1 |
| 12 | High prevalence of sick building syndrome in a new air conditional building in Italy显示文摘 | G ABBRIrlTI G MUZI M P ACCATYOLI | 1992 | Archives of Environmental Health1992，47，1： | 1 |
| 13 | Propofol,but Not Etomidate,Reduces Desflurane Mediated Sympathetic Activation in Human显示文摘 | LOPATRKA C W MUZI MEBERT T J | 1999 | Can J Anaesth1999，46，： | 1 |
| 14 | Induction of anesthesia and tracheal intubation with sevoflurane in adults显示文摘 | Muzi M Robinson B J Ebert TJ | 1996 | Anesthesiology1996，85，3： | 1 |
| 15 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，5： | 1 |
| 16 | Multifractal formalism for singular signals: Application to turbulence data显示文摘 | Muzy J F Bacry E Arneodo A | 1991 | Phys Rev Lett1991，67，： | 1 |
| 17 | The effects of premedication on inhaled induction of anesthesia with sevoflurane 显示文摘 | Muzi M Colinco MD Robinson B J | 1997 | Anesth Analg1997，85，5： | 1 |
| 18 | Venodilation contrioutes to propofol-mediated hypotension in humans 显示文摘 | Bereas RA Kampine JP | 1992 | Anaeshg Analgesia1992，74，： | 1 |
| 19 | Singularity spectum of fractal signal:exact results显示文摘 | Muzy J Arneodo A | 1993 | Journal of Stat Phys1993，70，34： | 1 |
| 20 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate 显示文摘 | EBERT T J MUZI M BERENS R | 1992 | Anesthesiaology1992，76，： | 1 |
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