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| 1 | Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy显示文摘Cancer immunotherapy is impaired by the intrinsic and adaptive immune resistance.Herein,a bispecific prodrug nanoparticle was engineered for circumventing immune evasion of the tumor cells by targeting multiple immune resistance mechanisms.A disulfide bond-linked bispecific prodrug of NLG919 and JQ1(namely NJ) was synthesized and self-assembled into a prodrug nanoparticle,which was subsequently coated with a photosensitizer-modified and tumor acidity-activatable diblock copolymer PHP for tumor-specific delivery of NJ.Upon tumor accumulation via passive tumor targeting,the polymeric shell was detached for facilitating intracellular uptake of the bispecific prodrug.NJ was then activated inside the tumor cells for releasing JQ1 and NLG919 via glutathione-mediated cleavage of the disulfide bond.JQ1 is a bromodomain-containing protein 4 inhibitor for abolishing interferon gamma-triggered expression of programmed death ligand 1.In contrast,NLG919 suppresses indoleamine-2,3-dioxygenase 1-mediated tryptophan consumption in the tumor microenvironment,which thus restores robust antitumor immune responses.Photodynamic therapy(PDT) was performed to elicit antitumor immunogenicity by triggering immunogenic cell death of the tumor cells.The combination of PDT and the bispecific prodrug nanoparticle might represent a novel strategy for blockading multiple immune evasion pathways and improving cancer immunotherapy. | Jiayi Ye Bo Hou Fangmin Chen Shunan Zhang Muya Xiong Tianliang Li Yechun Xu Zhiai Xu Haijun Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 2 | Simulation of Stress Distribution around Tunnels and Interaction between Tunnels Using an Elasto–plastic Model显示文摘This article presents a computer simulation of stress distribution around tunnels and interaction between tunnels using an elasto-plastic model. A finite element method using ANSYS software has been used for the analyses of one and two tunnels at different overburden depths with different separating distances between the tunnels. The results of numerical analyses indicate that stress distribution and stress concentration around the tunnels vary with the overburden depths. It is found that the coefficients of stress concentration for elasto-plastic medium are smaller than those for elastic one by 1.9%. Furthermore, the interaction between the two tunnels rapidly decreases with the increase of separation distance between them. In addition, for quantitatively describing the interaction between the two tunnels, a critical separation distance is introduced. The critical separation distances between the two tunnels at different overburden depths are 8 m, 12 m, and 14 m respectively. This fact is very important and essential for the design of mining tunnels and to ensure safety in tunnel engineering. | Muya M S 何波 王靖涛 李国成 | 2007 | Journal of China University of Geosciences2007，18，1： | 3 |
| 3 | Effects of Rock Bolting on Stress Distribution around Tunnel Using the Elastoplastic Model显示文摘To ensure the stability of a tunnel during construction, rock bolts are usually installed, which affects the stress distribution around the tunnel. Therefore, it is necessary to study the effects of rock bolting on the stress distribution around the tunnel. In this article, the effects of rock bolting on the stress distribution around the tunnel, including the position and orientation of bolts, the overburden depths, and the bolt lengths, are simulated using the ANSYS software with an elastoplastic model. The effect of multiple bolts of 2 m and 1 m lengths on the stress distribution in the roof and on the lateral sides of a tunnel and at different overburden depths is considered. An important finding is that the tensile stress region that is very dangerous for rock in the bottom of the tunnel grows rapidly with increasing overburden depths when rock bolts are installed only in the roof or on the lateral sides of a tunnel. The determination of the length of the rock bolt used around a tunnel is dependent on the loads and the integrity of the rock mass around the tunnel. In addition, rock bolting around the tunnel can obviously reduce the coefficients and the size of the region of stress concentration, especially when installed in high-stress areas. This fact is very important and essential for the design of tunnels and ensures engineering safety in tunnel engineering. | Muya M S 何波 王靖涛 李国成 | 2006 | Journal of China University of Geosciences2006，17，4： | 2 |
| 4 | RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy显示文摘It has been widely accepted that autophagic cell death exacerbates the progression of cerebral ischemia/reperfusion (I/R). Our previous study revealed that overexpression of reticulon protein 1-C (RTN1-C) is involved in cerebral I/R injury. However, the underlying mechanisms have not been studied intensively. This study was designed to evaluate the effect of RTN1-C on autophagy under cerebral I/R. Using an in vitro oxygen-glucose deprivation followed by reoxygenation and a transient middle cerebral artery occlusion model in rats, we found that the expression of RTN1-C protein was significantly upregulated. We also revealed that RTN1-C knockdown suppressed overactivated autophagy both in vivo and in vitro, as indicated by decreased expressions of autophagic proteins. The number of Beclin-1/propidium iodide-positive cells was significantly less in the LV-shRTN1-C group than in the LV-shNC group. In addition, rapamycin, an activator of autophagy, aggravated cerebral I/R injury. RTN1-C knockdown reduced brain infarct volume, improved neurological deficits, and attenuated cell vulnerability to cerebral I/R injury after rapamycin treatment. Taken together, our findings demonstrated that the modulation of autophagy from RTN1-C may play vital roles in cerebral I/R injury, providing a potential therapeutic treatment for ischemic brain injury. | Jun Ling Haijian Cai Muya Lin Shunli Qi Jian Du Lijian Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 2 |
| 5 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 6 | Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury显示文摘Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte scar.In the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair. | Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan Zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 7 | The need for technical auditing in the Zambian construction industry显示文摘 | Sichombo B Muya M Shakantu W | 2009 | International Journal of Project Management2009，27，： | 1 |
| 8 | Cost escalation and schedule delays in road construction projects in Zambia显示文摘 | Kaliba C Muya M Mumba K | | 0，，05： | 1 |
| 9 | Risk identification on communitybased construction projects in zambia显示文摘 | Manelele I Muya M | | 0，，02： | 1 |
| 10 | Effect of virginiamycin and monensin supplementation on performance of multiparous Holstein cows 显示文摘 | Erasmus L Muya C Erasmus S | 2008 | Livestock Science2008，119，1： | 1 |
| 11 | Cost escalation and schedule delays in road construction projects in Zambia显示文摘 | Chabota Kaliba Mundia Muya Kanyuka Mumba | 2008 | International Journal of Project Management2008，，5： | 1 |
| 12 | Rumen degradation of dry matter and organic matter of different bamma Parts显示文摘 | Kimambo A Muya H | 1991 | Livestock Re- search for Rural Development1991，3，3： | 1 |
| 13 | Theoretical Study of the Regioselectivity of the Interaction of 3-Methyl-4-pyrimidone and 1-Methyl-2-pyrimidone with Lewis Acids显示文摘 | Kasende O E Muya J T Broeckaert L | 2012 | J Phys Chem A2012，116，： | 1 |
| 14 | 显示文摘 | Suziki S Sakumoto H Muya S | 1984 | IEEE Trans Magn1984，20，1： | 1 |
| 15 | Construction dispute management and resolution in Zambia 显示文摘 | Musonda H M Muya M | 2010 | Journal of Legal Affairs and Dispute Resolution in Engineering and Construction2010，3，4： | 1 |
| 16 | Fe (Ⅲ) supported on resin as effective catalyst for the heterogeneous oxidation of phenol in aqueous solution显示文摘 | Reymay L Shihhsiung C Muya H Chinshan H Juinyih L | 2005 | Chemosphere2005，59，： | 1 |
| 17 | Development of a scale measuring the job satisfaction of Japanese hospital nurses显示文摘 | Muya M Katsuyama K Ozaki F | 2014 | Jpn J Nurs Sci2014，11，3： | 1 |
| 18 | Local law enforcement and ille- gal bushmeat hunting outside the Serengeti National Park, Tanza- nia显示文摘 | Holmern T Muya J Roskaft E | 2007 | Environmental Conservation2007，34，1： | 1 |
| 19 | The need for technical auditing in the zambian construction industry 显示文摘 | SICHOMBO B MUYA M SHAKANTU W | 2009 | International Journal of Project Management2009，27，8： | 1 |
| 20 | Theoretical study of the regioselectivity of the interaction of 3 - methyl - 4 - pyrimidone and 1 - methyl - 2 - pyrimi- done with Lewis acids 显示文摘 | KASENDE O E MUYA J T BROECKAERT L | 2012 | J Phys Chem A2012，116，： | 1 |
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