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| 1 | Transcriptional Wiring of Cell Wall-Related Genes in Arabidopsis显示文摘Transcriptional 协作,或合作表示,可以基因意味着相应蛋白质的功能的相关。例如,涉及第二等的房间墙纤维素生合成的几基因被共同表示,基因从事了木聚糖的合成,它是第二等的房间墙的一个主要部件。扩大分析的这些类型,我们调查了所有糖类活跃的酶(CAZy ) 的合作表示关系为 Arabidopsis thaliana 的相关基因。因此,意愿是 transcriptionally 连接不同房间墙相关的进程到互相,并且也到另外的生物函数。便于容易的用手的检查,我们作为网络和矩阵显示了这些相互作用,并且创造了为所有 transcriptional 协会包含可下载的文件的一个基于万维网的接口(http://gffzzd07dfdf4eb194e87hw65v5fu9fp0q6wff.ffgz.tsg.suse.edu.cn/corecarb ) 。 | Marek Mutwil Colin Ruprecht Federico M. Giorgi Martin Bringmann Bjorn Usadel Staffan Persson | 2009 | Molecular Plant2009，2，5： | 2 |
| 2 | GeneCAT-novel webtools that combine BLAST and co-expression analyses显示文摘 | Mutwil M φbro J Willats W G | 2008 | Nucleic Acids Research2008，36，： | 1 |
| 3 | Gene CAT-novel webtools that combine BLAST and co-expression analyses显示文摘 | Mutwil M Obro J Willats WG | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 4 | Towards revealing the functions of all genes in plants显示文摘 | Rhee S Y Mutwil M | 2014 | Trends in Plant Science2014，19，4： | 1 |
| 5 | Cellulose synthesis:A complex complex显示文摘 | Mutwil M Debolt S Persson S | 2008 | Current Opinionin Plant Biology2008，11，3： | 1 |
| 6 | Cellulose synthesis:a complex complex显示文摘 | Mutwil M Debolt S Persson S | | 0，，： | 1 |
| 7 | Cellulose synthesis: a complex complex 显示文摘 | Mutwil M Debult S | 2008 | Current Opinion in Plant Biology2008，11，3： | 1 |
| 8 | Ancestral genome reconstruction for studies of the green lineage显示文摘Ancestral sequence reconstruction has become a fundamental aspect of molecular evolution studies being used to trace small-scale sequence modifications through the course of the evolution of species.While first proposed in the 1960s(Zuckerkandl and Pauling,1965),it is much more recently that this discipline has attained prominence.Early studies were carried out in bacterial,followed by mammalian,systems,but more recently,the approach has additionally been used in plant studies,particularly those focused on the evolution of metabolism(Scossa and Fernie,2021). | Marek Mutwil Alisdair R.Fernie | 2023 | Molecular Plant2023，16，4： | 0 |
| 9 | Genomic,transcriptomic,and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites显示文摘Plants accumulate a vast array of secondary metabolites,which constitute a natural resource for pharmaceuticals.Oldenlandia corymbosa belongs to the Rubiaceae family,and has been used in traditional medicine to treat different diseases,including cancer.However,the active metabolites of the plant,their biosynthetic pathway and mode of action in cancer are unknown.To fill these gaps,we exposed this plant to eight different stress conditions and combined different omics data capturing gene expression,metabolic profiles,and anti-cancer activity.Our results show that O.corymbosa extracts are active against breast cancer cell lines and that ursolic acid is responsible for this activity.Moreover,we assembled a high-quality genome and uncovered two genes involved in the biosynthesis of ursolic acid.Finally,we also revealed that ursolic acid causes mitotic catastrophe in cancer cells and identified three high-confidence protein binding targets by Cellular Thermal Shift Assay(CETSA)and reverse docking.Altogether,these results constitute a valuable resource to further characterize the biosynthesis of active metabolites in the Oldenlandia group,while the mode of action of ursolic acid will allow us to further develop this valuable compound. | Irene Julca Daniela Mutwil-Anderwald Vaishnervi Manoj Zahra Khan Soak Kuan Lai Lay K.Yang Ing T.Beh Jerzy Dziekan Yoon P.Lim Shen K.Lim Yee W.Low Yuen I.Lam Seth Tjia Yuguang Mu Qiao W.Tan Przemyslaw Nuc Le M.Choo Gillian Khew Loo Shining Antony Kam James P.Tam Zbynek Bozdech Maximilian Schmidt Bjoern Usadel Yoganathan Kanagasundaram Saleh Alseekh Alisdair Fernie Hoi Y.Li Marek Mutwil | 2023 | Journal of Integrative Plant Biology2023，65，6： | 0 |
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