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| 1 | Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer显示文摘AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer. | Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto | 2007 | World Journal of Gastroenterology2007，13，21： | 8 |
| 2 | Phytosterols Act as Endocrine and Metabolic Disruptors in the European Polecat 显示文摘 | Nieminen P Mustonen A M Lindstrom-Seppa P | 2002 | Toxicology and Applied Pharmacology2002，178，： | 1 |
| 3 | Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB 显示文摘 | Hietaranta A Mustonen H Puolakkainen P | 2004 | Biochem Biophys Res Commun2004，323，1： | 1 |
| 4 | Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappa B 显示文摘 | Hietaranta A Mustonen H Puolakkainen P | 2004 | Biochem and Biophys Res Commun2004，323，1： | 1 |
| 5 | Effects of peracetic acid and UV irradiation on the inactivation of coliphages in wastewater显示文摘 | Rajala Mustonen R L Toivola P S Heinonen Tanski H | 1997 | Water Sci Technol1997，35，11： | 1 |
| 6 | Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappa B显示文摘 | HIETARANTA A MUSTONEN H PUOLAKKAINEN P | 2004 | Biochem Biophys Res Commun2004，323，： | 1 |
| 7 | Fasting reduces plasma leptin-and ghrelin-immunoreactive peptide concentrations of the burbot (Lota lota) at 2 degrees C but not at 10 degrees C 显示文摘 | Nieminen P Mustonen A M Hyvarinen H | 2003 | Zool Sci2003，20，9： | 1 |
| 8 | Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study显示文摘 | Mustonen P Lehtonen KV Javela K | 2014 | Lupus2014，23，14： | 1 |
| 9 | Volunteer tourism: Postmodern pilgrimage? 显示文摘 | Mustonen P | 2006 | Journal of Tourism and CulturalChange2006，3，3： | 1 |
| 10 | The influence of peritoneal dialysis and the use of subcutaneous and intraperitoneal insulin on glucose metabolism and serum lipids in type 1 diabetic patients显示文摘 | Nevalainen P Lahtelal JT Mustonen J | 1997 | Nephrol Dial Transpl1997，12，： | 1 |
| 11 | Primary spontaneous pneu- mothorax in two siblings suggests autosomal recessive inherit- ance显示文摘 | KOIVISTO P A MUSTONEN A | 2001 | Chest2001，119，5： | 1 |
| 12 | Bisphenol A affects endocrine physiology and biotransformation enzymeactivities of the field vole(Microtus agrestis)显示文摘 | Nieminen P Lindstr6m-Sepp/i P Mustonen AM | 2002 | Oen Comp Endoerinol2002，126，： | 1 |
| 13 | The surgical and ontolog- ical safety of immediate breast reeonstruction显示文摘 | Mustonen P Lepisto J Papp A | 2004 | Eur J Surq Oncol2004，30，8： | 1 |
| 14 | Clinical and laboratory risk factors of thrombotic complications after pacemaker implanta- tion : A prospective study 显示文摘 | Korkeila P Mustonen P Koistinen J | 2010 | Europace2010，12，6： | 1 |
| 15 | Persis- tent antiphospholipid antibody (aPL)in asymptomatic carri- ers as a risk factor for future thrombotic events : a nationwide prospective study显示文摘 | MUSTONEN P LEHTONEN KV JAVELA K | 2014 | Lupus2014，0，： | 1 |
| 16 | MRI of acute me- niscal iniury associated with tibial plateau fractures: prevalence, type, and location显示文摘 | Mustonen A O Koivikko M P Lindahl J | 2008 | AJR2008，191，4： | 1 |
| 17 | Ion chroma-tographic method for the determination of selected inorganic anions and organic acids from raw and drinking waters us-ing suppressor current switching to reduce the backgr-ound noise显示文摘 | Rantakokko P Mustonen S Yritys M | 2004 | Journal of Liquid Chromatography & Re-lated Technologies2004，27，5： | 1 |
| 18 | Fasting re- duces plasma leptin - and ghrelin - immunoreactive peptide concen- trations of the burbot (Lota lota) at 2 degree C but not at 10 degree C显示文摘 | NIEMINEN P MUSTONEN A M HYVARINEN H | 2003 | Zoolog Sci2003，20，9： | 1 |
| 19 | Fasting reduces plasma leptin-and ghrelin-immunore- active peptide concentrations of the burbot (Lota lota) at 2 C but not at 10 C 显示文摘 | NIEMINEN P MUSTONEN A M HYVARINEN H | 2003 | Zoological Science2003，20，9： | 1 |
| 20 | The influence of peritoneal dialysis and the use of subcutaneous and intraperitoneal insulin on glucose metabolism and serum lipids in type 1 diabetic patients显示文摘 | Nevalainen P Lahtela J T Mustonen J | 1997 | Nephrol Dial Transplant1997，12，1： | 1 |
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