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| 1 | High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling显示文摘Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability,osteogenic effects,and biocompatibility.Magnesium has been proven to promote distraction osteogenesis.However,its mechanism of promoting distraction osteogenesis is not thoroughly studied.In this work,a high-purity magnesium pin developed and applied in rat femur distraction osteogenesis.Mechanical test,radiological and histological analysis suggested that high-purity magnesium pin can promote distraction osteogenesis and shorten the consolidation time.Further RNA sequencing investigation found that alternative Wnt signaling was activated.In further bioinformatics analysis,it was found that the Hedgehog pathway is the upstream signaling pathway of the alternative Wnt pathway.We found that Ptch protein is a potential target of magnesium and verified by molecular dynamics that magnesium ions can bind to Ptch protein.In conclusion,HP Mg implants have the potential to enhance bone consolidation in the DO application,and this process might be via regulating Ptch protein activating Hedgehog-alternative Wnt signaling. | Musha Hamushan Weijie Cai Yubo Zhang Zun Ren Jiafei Du Shaoxiang Zhang Changli Zhao Pengfei Cheng Xiaonong Zhang Hao Shen Pei Han | 2021 | Bioactive Materials2021，6，6： | 3 |
| 2 | Safety of SARS-CoV-2 vaccines:a systematic review and meta-analysis of randomized controlled trials显示文摘Background Various modalities of vaccines against coronavirus disease 2019(COVID-19),based on different platforms and immunization procedures,have been successively approved for marketing worldwide.A comprehensive review for clinical trials assessing the safety of COVID-19 vaccines is urgently needed to make an accurate judgment for mass vaccination.Main text A systematic review and meta-analysis was conducted to determine the safety of COVID-19 vaccine candidates in randomized controlled trials(RCTs).Data search was performed in PubMed,Embase,Cochrane library,Scopus,Web of Science,and MedRxiv.Included articles were limited to RCTs on COVID-19 vaccines.A total of 73,633 subjects from 14 articles were included to compare the risks of adverse events following immunization(AEFI)after vaccinating different COVID-19 vaccines.Pooled risk ratios(RR)of total AEFI for inactivated vaccine,viral-vectored vaccine,and mRNA vaccine were 1.34[95%confidence interval(CI)1.11–1.61,P<0.001],1.65(95%CI 1.31–2.07,P<0.001),and 2.01(95%CI 1.78–2.26,P<0.001),respectively.No significant differences on local and systemic AEFI were found between the first dose and second dose.In addition,people aged≤55 years were at significantly higher risk of AEFI than people aged≥56 years,with a pooled RR of 1.25(95%CI 1.15–1.35,P<0.001).Conclusions The safety and tolerance of current COVID-19 vaccine candidates are acceptable for mass vaccination,with inactivated COVID-19 vaccines candidates having the lowest reported AEFI.Long-term surveillance of vaccine safety is required,especially among elderly people with underlying medical conditions. | Musha Chen Yue Yuan Yiguo Zhou Zhaomin Deng Jin Zhao Fengling Feng Huachun Zou Caijun Sun | 2021 | Infectious Diseases of Poverty2021，10，4： | 2 |
| 3 | Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: A case report显示文摘我们报导多重十二指肠、胰腺、胃的良性肿瘤的一个案例。A 67- 岁女人为十二指肠的良性肿瘤的治疗进入我们的医院。实验室测试表明病人与 macrocytic 和 hypergastrinemia 被联系,并且类型 A 胃炎被 gastrofiberscopy 显示出。在外科期间,另一个肿瘤顺便说一下在胰的头被发现。在十二指肠和胰的肿瘤被胰头十二指肠切除术完全切除并且 immunohistologically 作为促胃液素诊断了 -- 并且生产血清素的良性肿瘤分别地。病理学的检查表明除了非常发现的良性肿瘤,有无临床症状的良性肿瘤,其一是内分泌的房间 micronest,在胃和十二指肠定位了。在十二指肠,胰,和胃的肿瘤词法上从对方显示出不同特征并且免疫化学上。尽管没有权威的证据被获得了,某种基因异例可能涉及了这种情况,并且 hypergastrinemia 可以由于十二指肠的 gastrinoma 导致多重胃的良性肿瘤。 | Takeo Bamba Shin-ichi Kosugi Tatsuo Kanda Toshihiro Tsubono Yasuo Sakai Nobuyuki Musha Noriko Ishihara Katsuyoshi Hatakeyama | 2007 | World Journal of Gastroenterology2007，13，15： | 2 |
| 4 | EEG filtering based on blind source separation (BSS) for early detection of Alzheimer' s disease 显示文摘 | Ciehocki A Shishkin S Musha T Leonowicz Z Asada T and Kurachi T | 2005 | Clinical Neurophysiology2005，116，3： | 1 |
| 5 | Instantaneous structural intensity by the harmonic wavelet transform 显示文摘 | Musha T Kumazama T | 2007 | Journal of Sound and Vibration2007，306，12： | 1 |
| 6 | Angiographic demonstration of intrahepatic arterio-portal anastomoses in hepatocelluar carcinoma显示文摘 | Okuda K Musha H Yamasaki T | 1977 | Radiology1977，122，： | 1 |
| 7 | Angiographic demonstration of intrahepatic arterio-portal anastomoses in hepatocellular carcinoma显示文摘 | Okuda K Musha H Yamasaki T | 1977 | Radiology1977，122，1： | 1 |
| 8 | Clinical usefulness of the dipole traeing method for loealizing interietal spikes in partial epilepsy显示文摘 | Shindo K Ikeda A Musha T | 1998 | Epilepsia1998，39，： | 1 |
| 9 | Electric dipole tracing in the brain by means of the boundary element method and its accuracy 显示文摘 | MUSHA T OKAMOTO Y | 1987 | IEEE Trans on Biomedical Engineering1987，34，： | 1 |
| 10 | Cystatin C: a better marker to detect coronary artery sclerosis 显示文摘 | Sekizuka H Akashi Y J Kawasaki K Yamauehi M Musha H | 2009 | J Cardiol2009，54，： | 1 |
| 11 | hnpact of contrast induced nephropathy and cardiovascular events by serum cystatin C in renal insufficiency patients undergoing cardiac catheterization 显示文摘 | Ishibashi Y Yamauchi M Musha H | 2010 | Angiology2010，61，8： | 1 |
| 12 | Instantaneous structural intensity by theharmonic wavelet transform显示文摘 | Musha T Kumazawa T | 2007 | Journal of Sound and Vibration2007，，306： | 1 |
| 13 | Impact of contrast- induced nephropathy and cardiovascular events by serum cystatin C in renal insufficiency patients undergoing cardiac catheterization显示文摘 | Isbibashi Y Yamauchi M Musha H | 2010 | Angiology2010，61，8： | 1 |
| 14 | Impact of contrastinducednephropathy and cardiovascular events by serum cystatin C in renal insufficiency patients undergoing cardiac catheterization显示文摘 | Ishibashi Y Yamauchi M Musha H | 2010 | Angiology2010，61，8： | 1 |
| 15 | Generation of radially polarized mode in Yb fiber laser by using a dual conical prism 显示文摘 | LI Ji lang Ueda K I MUSHA M | 2006 | Opt Lett2006，31，20： | 1 |
| 16 | Do optimal dipoles obtained by the dipole tracing method always suggest true source localizations 显示文摘 | HOMMA S | 1990 | Brain Topography1990，3，： | 1 |
| 17 | Residual pump light as a probe of the self-pulsing instability in an ytterbium-doped fiber laser显示文摘 | LI J L UEDA K I MUSHA M | 2006 | Opt Lett2006，31，10： | 1 |
| 18 | Converging-axicon- based radially polarized ytterbium fiber laser and evidence on the mode profile inside the gain fiber显示文摘 | LIJI-lang Ueda K I MUSHA M | 2007 | Opt Lett2007，32，11： | 1 |
| 19 | Forward and inverse problems of EEG dipole localization 显示文摘 | OKAMOTO Y | 1999 | Critical Reviews in Biomedical Engineering1999，27，35： | 1 |
| 20 | Location of Electric current sources in the human brain estimated by the dipole tracing method of the scalp-skull-brain (SSB) head model显示文摘 | Homma S Musha T Nakajima T | 1994 | Electroencephalogr Clin Neuro- physiol1994，91，： | 1 |
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