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您的检索式：作者名="Musa Garba Abdullahi"
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| 1 | SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review显示文摘The present pandemic has posed a crisis to the economy of the world and the health sector.Therefore,the race to expand research to understand some good molecular targets for vaccine and therapeutic development for SARS-CoV-2 is inevitable.The newly discovered coronavirus 2019(COVID-19)is a positive sense,single-stranded RNA,and enveloped virus,assigned to the beta CoV genus.The virus(SARS-CoV-2)is more infectious than the previously detected coronaviruses(MERS and SARS).Findings from many studies have revealed that S protein and RdRp are good targets for drug repositioning,novel therapeutic development(antibodies and small molecule drugs),and vaccine discovery.Therapeutics such as chloroquine,convalescent plasma,monoclonal antibodies,spike binding peptides,and small molecules could alter the ability of S protein to bind to the ACE-2 receptor,and drugs such as remdesivir(targeting SARS-CoV-2 RdRp),favipir,and emetine could prevent SASR-CoV-2 RNA synthesis.The novel vaccines such as mRNA1273(Moderna),3LNP-mRNAs(Pfizer/BioNTech),and ChAdOx1-S(University of Oxford/Astra Zeneca)targeting S protein have proven to be effective in combating the present pandemic.Further exploration of the potential of S protein and RdRp is crucial in fighting the present pandemic. | Yusuf Muhammed Abduljalal Yusuf Nadabo Mkpouto Pius Bashiru Sani Jafar Usman Nasir Anka Garba Jaafaru Mohammed Sani Basit Opeyemi Olayanju Sunday Zeal Bala Musa Garba Abdullahi Misbahu Sambo | 2021 | Biosafety and Health2021，3，5： | 1 |
| 2 | Central depressant activity of butanol fraction of Securinega virosa root bark in mice显示文摘 | Mohammed Garba Magaji Abdullahi Hamza Yaro Aliyu Muhammad Musa Joseph Akponso Anuka Ibrahim Abdu-Aguye Isa Marte Hussaini | 2012 | Journal of Ethnopharmacology2012，，1： | 1 |
| 3 | Phytochemical screening and anticonvulsant studies of ethyl acetate fraction of Globimetula braunii on laboratory animals显示文摘Objective:To investigate the phytochemical properties and the anticonvulsant potential of the ethyl acetate soluble fraction of ethanol leaf extract of Globimetida braunii,a plant used in ethnomedicine for the treatment of epilepsy.Methods:The phytochemical screening was carried out using standard protocol while the anticonvulsant activity was studied using maximal electroshock test in chicks,pentylenetetrazole and 4-aminopyridine—induced seizures in mice.Results:The preliminary phytochemical screening carried out on the crude ethanol extract revealed the presence of saponins,carbohydrates,flavonoids,tannins,anthraquinones and steroids.Similarly,tannins,flavonoids and steroids/terpenes were found to be present in the ethyl acetate fraction,In the pharmacological screening,150 mg/kg of the fraction protected 83.33%of animals against pentylenetetrazole-induced seizure in mice whereas sodium valproate a standard anti-epileptic drug offered 100%protection.In the 4-aminopyridine-induced seizure model,the fraction produced a significant(P<0.05)increase in the mean onset of seizure in unprotected animals.The fraction did not exhibit a significant activity against maximal electroshock convulsion.The median lethal dose of the fraction was found to be 1261.91 mg/kg.Conclusions:These results suggest that the ethyl acetate fraction of Globimetula braunii leaves extract possesses psychoactive compound that may be useful in the management of petit mal epilepsy and lend credence to the ethnomedical use of the plant in the management of epilepsy. | Musa Mumammad Aliyu Abdullahi Isma'il Musa Muhammad Ja'afar Kanial Magaji Garba Mohammed | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，4： | 0 |
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